A5028417315- Photoreceptor and optogenetics research
- Neuroscience and Neural Engineering
- Neural dynamics and brain function
- Photoacoustic and Ultrasonic Imaging
- Advanced Fluorescence Microscopy Techniques
- Optical Imaging and Spectroscopy Techniques
- Ultrasound and Hyperthermia Applications
- EEG and Brain-Computer Interfaces
- Retinal Development and Disorders
- Optical Coherence Tomography Applications
- Olfactory and Sensory Function Studies
- Digital Holography and Microscopy
- Neural Networks and Applications
- Cell Image Analysis Techniques
- Ultrasound Imaging and Elastography
- 3D Printing in Biomedical Research
- Spectroscopy Techniques in Biomedical and Chemical Research
- Nanoplatforms for cancer theranostics
- Ultrasound and Cavitation Phenomena
- Photochromic and Fluorescence Chemistry
- Advanced Optical Imaging Technologies
- Advanced Memory and Neural Computing
- CCD and CMOS Imaging Sensors
- Neurobiology and Insect Physiology Research
- bioluminescence and chemiluminescence research
NYU Langone Health
2017-2024
New York University
2019-2024
Neuroscience Institute
2019-2024
Hinge Health
2020-2022
Technion – Israel Institute of Technology
2009-2018
University of Haifa
2017
InSightec (Israel)
2016
Carmel (Israel)
2016
Technical University of Munich
2012
Helmholtz Zentrum München
2012
The purpose of this study was to develop a unified model capable explaining the mechanisms interaction ultrasound and biological tissue at both diagnostic nonthermal, noncavitational (<100 mW·cm −2 ) therapeutic, potentially cavitational (>100 spatial peak temporal average intensity levels. cellular-level (termed “bilayer sonophore”) combines physics bubble dynamics with cell biomechanics determine dynamic behavior two lipid bilayer membrane leaflets. existence such could pave way...
Abstract Diverse translational and research applications could benefit from the noninvasive ability to reversibly modulate (excite or suppress) CNS activity using ultrasound pulses, however, without clarifying underlying mechanism, advanced design-based ultrasonic neuromodulation remains elusive. Recently, intramembrane cavitation within bilayer membrane was proposed underlie both biomechanics biophysics of acoustic bio-effects, potentially explaining cortical stimulation results through a...
Recent discovery of neuronal stimulation by low-intensity, focused ultrasound waves has ignited high hope and research effort to develop a noninvasive way assess control brain activity with millimeter spatial resolution. But how does the phenomenon work? Scientists now propose first concrete biophysical model explain, both qualitatively quantitatively, guide methodological development.
Abstract A functional magnetic resonance imaging (fMRI) study was conducted during which seven subjects carried out naturalistic tactile object recognition (TOR) of real objects. Activation maps, conjunctions across subjects, were compared between tasks involving TOR common objects, palpation “nonsense” and rest. The involved similar motor sensory stimulation, allowing higher processes to be isolated. Compared nonsense palpation, the most prominent activation evoked by in secondary...
Non-invasive observation of spatiotemporal activity large neural populations distributed over entire brains is a longstanding goal neuroscience. We developed volumetric multispectral optoacoustic tomography platform for imaging activation deep in scattering brains. It can record 100 frames per second across scalable fields view ranging between 50 and 1000 mm3 with respective spatial resolution 35-200 μm. Experiments performed immobilized freely swimming larvae adult zebrafish expressing the...
Ensemble activity and perception The mechanisms by which sensory percepts are encoded in neural ensembles still incompletely understood. Chong et al. used single-spot optogenetic stimulation to control neuronal mouse olfactory glomeruli space time. Animals were trained recognize a learned pattern that was likely perceived as specific odor. authors then systematically varied the patterns changing either activated or timing between activation of evaluate their impact on odor recognition....
In recent years, optogenetics has become a central tool in neuroscience research. Estimating the transmission of visible light through brain tissue is crucial importance for controlling activation levels neurons different depths, designing optical systems, and avoiding lesions from excessive power density. The Kubelka-Munk model Monte Carlo simulations have previously been used to propagation rodents' tissue, however, these prior attempts suffer fundamental shortcomings. Here, we introduce...
Rapid temperature pulses can increase the capacitance of cell membranes (a key mechanism in techniques for restoring neural function), but underlying biophysics is not well understood. A new predictive model shows that tiny changes membrane dimensions, mediated by fluctuations, are responsible.
Ultrasound-mediated neuromodulation is emerging as a key technology for targeted noninvasive brain stimulation, but insights into its effects and dose-response characteristics are still missing. The purpose of this study to systematically evaluate the effect low-intensity transcranial ultrasound stimulation (TUS) on complementary aspects cerebral hemodynamic. We simultaneously record EMG signal, local field potential (LFP) cortical blood flow (CBF) using electrophysiological recording laser...
Neural activity in primary motor cortex (MI) is known to correlate with hand position and velocity. Previous descriptions of this tuning have (1) been linear or velocity, (2) depended only instantaneously on these signals, and/or (3) not incorporated the effects interneuronal dependencies firing rate. We show here that many MI cells encode a superlinear function full time-varying trajectory. Approximately 20% carry information trajectory beyond just position, acceleration at single time lag....
To examine the network-level organizing principles by which brain achieves its real-time encoding of episodic information, we have developed a 96-channel array to simultaneously record activity patterns as many 260 individual neurons in mouse hippocampus during various startling episodes. We find that mnemonic episodes triggered firing changes set CA1 both startle-type and environment-dependent manners. Pattern classification methods reveal these form distinct ensemble representations...
Computer-generated holography is an emerging technology for stimulation of neuronal populations with light patterns. A holographic photo-stimulation system may be designed as a powerful research tool or compact neural interface medical device, such optical retinal prosthesis. We present here overview the main design issues including choice field-of-view, resolution, physical size, generation two- and three-dimensional patterns their diffraction efficiency, algorithms computational effort....
Speckle is a major source of noise in holographic projection. Time averaging multiple holograms may be used to reduce speckle contrast, but must calculated per each frame, costing computational power. We show that single hologram generate fully speckle-free reconstruction, by cyclic shifting and time averaging. demonstrate the concept experimentally, discuss its application for high-rate projection systems.