A5102807565- Anesthesia and Neurotoxicity Research
- Cyclopropane Reaction Mechanisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune Response and Inflammation
- Asymmetric Synthesis and Catalysis
- Intensive Care Unit Cognitive Disorders
- Epigenetics and DNA Methylation
- HER2/EGFR in Cancer Research
- Dermatology and Skin Diseases
- Bone and Dental Protein Studies
- Cardiac Ischemia and Reperfusion
- Nitric Oxide and Endothelin Effects
- Synthesis and Characterization of Pyrroles
- Synthesis and Reactivity of Heterocycles
- Analytical Chemistry and Sensors
- Advancements in Transdermal Drug Delivery
- Oxidative Organic Chemistry Reactions
- Autophagy in Disease and Therapy
- Gut microbiota and health
- interferon and immune responses
- Multicomponent Synthesis of Heterocycles
- Monoclonal and Polyclonal Antibodies Research
- Phosphorus compounds and reactions
- Dental Erosion and Treatment
- Liver Diseases and Immunity
Yuhuangding Hospital
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2024
Shanghai Jiao Tong University
2016-2024
XinHua Hospital
2024
Shandong University
2022-2023
First Affiliated Hospital of Fujian Medical University
2023
Fujian Medical University
2023
Yangzhou University
2018-2023
Shandong Provincial Hospital
2023
Wenzhou Institute of Industrial Science
2021-2022
Sepsis is an often fatal condition that arises when the immune response to infection causes widespread systemic organ injury. A critical unmet need in combating sepsis lack of accurate early biomarkers produce actionable results busy clinical settings. Here, we report development a point-of-care platform for rapid detection. Termed IBS (integrated biosensor sepsis), our approach leverages (i) pathophysiological role cytokine interleukin-3 (IL-3) and (ii) hybrid magneto-electrochemical sensor...
Background: Sirtuin7 (SIRT7) is a type of nicotinamide adenine dinucleotide oxidized form (NAD+)-dependent deacetylase and the least understood member sirtuins family; it implicated in various processes, such as aging, DNA damage repair cell signaling transduction. There some evidence that SIRT7 may function tumor trigger for human malignancy. Here, we aimed to explore biological ovarian carcinoma cells its potential mechanism. Materials Methods: Expression cancer lines was detected by...
Abstract Objective To investigate the distribution of health literacy (HL) levels and association HL with proactive personality in patients permanent colostomy. Methods A cross-sectional study was conducted to measure using validated scales. total 172 colostomy were selected from January 2021 May 2022 Yantai City, China. Descriptive statistics, t -test, ANOVA, Pearson correlation analysis, multiple linear regression analysis techniques used. Results The results obtained showed that status...
Chaperone-mediated autophagy (CMA) serves as a critical upstream regulator of lipophagy and lipid metabolism in hepatocyte. However, the role CMA macrophage, typical component atherosclerotic plaque, remains unclear. In our study, LAMP-2A (L2A, marker) was reduced macrophages exposed to high dose oleate, impaired advanced atherosclerosis ApoE (-/-) mice. Primary peritoneal isolated from macrophage-specific L2A-deficient mice exhibited pronounced intracellular accumulation. Lipid regulatory...
Our laboratory has previously shown that the administration of tumor necrosis factor (TNF), a cytokine produced by activated mononuclear cells, to guinea pigs produces syndrome similar gram-negative sepsis or ARDS. Pentoxifylline (PTX), methylxanthine, protects against TNF-induced and sepsis-induced acute lung injury in vivo. We now report on vitro cellular studies PMN-mediated Its attenuation. studied bovine pulmonary artery endothelial cell (EC) cytotoxicity both with without PMN. A 51Cr...
Background: Doxorubicin (DOX)-induced cardiotoxicity is a highly concerning issue, and the mechanism by which DOX induces likely to be multifactorial. NADPH oxidase (NOX) associated with DOX-induced cardiotoxicity. Setanaxib (GKT137831), preferential direct inhibitor of NOX1 NOX4, can delay or prevent progression many cardiovascular disorders inhibiting reactive oxygen species (ROS) generation. In this study, we investigated role GKT137831 in ameliorating potential mechanisms its action....
Abstract Background Declined skeletal muscle mass and function are inevitable consequences of long‐term diabetes bring about many adverse events. Muscle fibre atrophy interstitial fibrosis major pathological manifestations diabetic sarcopenia. Stimulator interferon genes (STING) participates in various metabolic diseases. We aimed to explore whether how STING regulates the above Methods Wild‐type gt/gt C57BL/6J mice C2C12 myotubes were used study role regulation sarcopenia underlying...
The objective of this study is to compare the efficacy and complications endoscopic microscopic transsphenoidal surgery in treatment pituitary adenomas. A total 105 follow-up cases including 60 45 were treated our hospital between January 2012 November 2014. approach had a higher rate gross tumor removal (81.7% versus 62.2%, P < 0.05) as well lower postoperative (18.3% 35.6%, than that group. There was no significant difference rates visual improvement cerebrospinal fluid leak group (P >...
The continual resistance to antibiotics and the generation of a series bacterial infections has emerged as global concern, which requires appropriate measures therapeutics address such menace. Herein, we report on Silk fibroin (SF) hydrogel with good biocompatibility biodegradability fabricated through crosslinking SF different concentrations Gallium nitrate (Ga (NO3)3) against Pseudomonas aeruginosa. However, SF: Ga = 500: 1 (w/w) (SF/Ga) demonstrated bactericidal wound healing effect...
The aging of the population has led to an annual increase in incidence vascular calcification (VC). Specific protein 1 (Sp1) is a transcriptional activator that serves important role VC. deacetylation transcription factors represses their binding promoters downstream genes, thereby causing downregulation. present study aimed investigate deacetylated Sp1 development In study, western blotting and immunoprecipitation (IP) were performed detect levels acetylated Sp1. Western immunofluorescence...
The three-component reaction of isoquinolines, dialkyl acetylenedicarboxylates, and 5,6-unsubstituted 1,4-dihydropyridines in acetonitrile at room temperature afforded functionalized isoquinolino[1,2-f][1,6]naphthyridines good yields with high diastereoselectivity. More importantly, the formal [2 + 2] cycloaddition acetylenedicarboxylates refluxing gave unique 2-azabicyclo[4.2.0]octa-3,7-dienes as major products 1,3a,4,6a-tetrahydrocyclopenta[b]pyrroles minor via further rearrangement.
The tri(n-butyl)phosphine-catalyzed reaction of isatylidene malononitriles and bis-chalcones in chloroform at 65 °C afforded functionalized spiro[cyclohexane-1,3'-indolines] good yields with diastereoselectivity. On the other hand, 3-(ethoxycarbonylmethylene)oxindoles gave different regioselectivity. Additionally, tri(n-butyl)phosphine-promoted domino annulation isatins ethyl cyanoacetates produced spiro[indoline-3,2'-furan-3',3''-indolines] satisfactory yields.
Abstract Polymorphonuclear leukocytes (PMN) may play a key role in acute lung injury and ARDS. The mechanisms of PMN‐mediated include the release inflammatory mediators, such as oxygen free radicals which cause direct tissue injury, arachidonic acid metabolites pulmonary vasoconstriction increased vascular permeability. goals this vitro study were (1) to assess effects PMN‐activating agents (lipopolysaccharide, LPS; phorbol myristate acetate, PMA; tumor necrosis factor, TNF) on PMN...
Pentoxifylline (PTX), a methylxanthine, can suppress polymorphonuclear leukocyte (PMN) activation and attenuate sepsis-induced acute lung injury. We investigated whether PTX prevents non-PMN-dependent First we studied four groups of granulocyte-depleted guinea pigs (control, PTX, Escherichia coli, E. coli + PTX). Lung injury was assessed by wet-to-dry weight (W/D) ratio tissue-to-plasma 125I-albumin (albumin index, AI). The group showed significant increase in the W/D AI compared with...
Discovering regulatory interactions between genes that specify the behavioral properties of cells remains an important challenge. We used dynamics transcriptional changes resolved by PRO-seq to identify a network responsible for endocrine resistance in breast cancer. show GDNF leads switching active state bi-stable feedback loop GDNF, EGR1, and master transcription factor ERα. stimulates MAP kinase, activating factors SRF AP-1. initiates immediate response, EGR1 suppressing Newly translated...