A5026244823- Cell Image Analysis Techniques
- Digital Holography and Microscopy
- Image Processing Techniques and Applications
- Bone Tissue Engineering Materials
- Polymer Surface Interaction Studies
- Graphene and Nanomaterials Applications
- Advanced biosensing and bioanalysis techniques
- MXene and MAX Phase Materials
- Advanced Sensor and Energy Harvesting Materials
- Extracellular vesicles in disease
- Advanced Biosensing Techniques and Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced Fiber Optic Sensors
- Biosensors and Analytical Detection
- Congenital heart defects research
- GaN-based semiconductor devices and materials
- ZnO doping and properties
- Microfluidic and Capillary Electrophoresis Applications
- Piezoelectric Actuators and Control
- Metal and Thin Film Mechanics
- Orthopaedic implants and arthroplasty
- Nanopore and Nanochannel Transport Studies
- Advanced Materials and Mechanics
- Characterization and Applications of Magnetic Nanoparticles
- Molecular Biology Techniques and Applications
University of Michigan
2022-2025
Hanyang University
2009-2025
Pohang Iron and Steel (South Korea)
2025
Massachusetts General Hospital
2017-2023
Center for Systems Biology
2017-2023
Michigan United
2023
Harvard University
2017-2021
Massachusetts Institute of Technology
2014-2019
Koch Institute for Integrative Cancer Research At MIT
2014-2017
Allen Institute
2014-2017
Infections associated with orthopedic implants cause increased morbidity and significant healthcare cost. A prolonged expensive two-stage procedure requiring two surgical steps a 6–8 week period of joint immobilization exists as today's gold standard for the revision arthroplasty an infected prosthesis. Because infection is much more common in implant replacement surgeries, these issues greatly impact long-term patient care continually growing part population. Here, we demonstrate that...
Sepsis is an often fatal condition that arises when the immune response to infection causes widespread systemic organ injury. A critical unmet need in combating sepsis lack of accurate early biomarkers produce actionable results busy clinical settings. Here, we report development a point-of-care platform for rapid detection. Termed IBS (integrated biosensor sepsis), our approach leverages (i) pathophysiological role cytokine interleukin-3 (IL-3) and (ii) hybrid magneto-electrochemical sensor...
Using siRNA therapeutics to treat hematologic malignancies has been unsuccessful because blood cancer cells exhibit remarkable resistance standard transfection methods. Herein we report the successful delivery of with a dual-targeted, layer-by-layer nanoparticle (LbL-NP). The LbL-NP protects from nucleases in bloodstream by embedding it within polyelectrolyte layers that coat polymeric core. outermost layer consists hyaluronic acid (a CD44-ligand) covalently conjugated CD20 antibodies....
Abstract Plasmonic biosensors have demonstrated superior performance in detecting various biomolecules with high sensitivity through simple assays. Scaled‐up, reproducible chip production a density of hotspots large area has been technically challenging, limiting the commercialization and clinical translation these biosensors. A new fabrication method for 3D plasmonic nanostructures density, volume therefore inherently improved detection capabilities is developed. Specifically, Au...
Abstract Extracellular vesicles (EVs)—nanoscale phospholipid secreted by cells—present new opportunities for molecular diagnosis from non‐invasive liquid biopsies. Single EV protein analysis can be extremely valuable in studying EVs as circulating cancer biomarkers, but it is technically challenging due to weak detection signals associated with limited amounts of epitopes and small surface areas antibody labeling. Here, a new, simple method that enables multiplexed analyses markers improved...
Lens-free digital in-line holography (LDIH) is a promising microscopic tool that overcomes several drawbacks (e.g., limited field of view) traditional lens-based microcopy. However, extensive computation required to reconstruct object images from the complex diffraction patterns produced by LDIH. This limits LDIH utility for point-of-care applications, particularly in resource settings. We describe deep transfer learning (DTL) based approach process context cellular analyses. Specifically,...
Abstract All‐solid‐state batteries (ASSBs) are promising “beyond lithium‐ion batteries” candidates owing to their high energy density and safety. Anodeless electrodes critical components for enabling these attributes, offering a fundamentally distinct mechanism compared conventional anode systems. This unique of anodeless has garnered significant scientific interest prompted extensive research. Based on recent advancements, this perspective provides comprehensive insights into electrode...
Abstract As the demand for high‐performance energy storage solutions increases, lithium‐ion batteries (LIBs) remain leading technology in electric vehicles (EVs) and portable electronics. However, traditional wet‐casting electrode (WCE) processes have inherent limitations, such as binder migration environmental concerns associated with solvent use. In this study, a high‐loading dry‐casting (DCE) approach is proposed to overcome these challenges by eliminating use improving uniformity. The...
The absence of efficient red-emitting micrometer-scale light emitting diodes (LEDs), i.e., LEDs with lateral dimensions 1 μm or less is a major barrier to the adoption microLEDs in virtual/augmented reality. underlying challenges include presence extensive defects and dislocations for indium-rich InGaN quantum wells, strain-induced quantum-confined Stark effect, etch-induced surface damage during fabrication well microLEDs. Here, we demonstrate new approach achieve strong red emission (...
Effective tissue regeneration and immune responses are essential for the success of biomaterial implantation. Although interaction between synthetic materials biological systems is well-recognized, role surface topographical cues in regulating local osteoimmune microenvironment─specifically, their impact on host cells, dynamic interactions─remains underexplored. This study addresses this gap by investigating topography osteogenesis immunomodulation. We fabricated MXene/hydroxyapatite...
Abstract Embryonic development is a remarkably complex and rapidly evolving morphogenetic process. Although many of the early patterning events have been well described, understanding anatomical changes at later stages where clinically relevant malformations are more likely to be survivable has limited by lack quantitative 3D imaging tools. Microcomputed tomography (Micro‐CT) emerged as powerful tool for embryonic imaging, but analysis organ tissue growth not conducted. In this study, we...
Abstract Micro‐computed tomographic imaging of a stage HH36 chick embryo. Signal intensity was pseudocolored to identify skeletal, vascular, and soft tissue components. See Kim et al., on page 1, in this issue.
The global burden of cancer, severe diagnostic bottlenecks in underserved regions, and underfunded health care systems are fueling the need for inexpensive, rapid, treatment-informative diagnostics. On basis advances computational optics deep learning, we have developed a low-cost digital system, termed AIDA (artificial intelligence diffraction analysis), breast cancer diagnosis fine needle aspirates. Here, show high accuracy (>90%) (i) recognizing cells directly from patterns (ii)...
An automated image cytometry system was developed to enable rapid cancer profiling of scant cellular specimens obtained by fine needle aspiration.
Abstract Infections are a significant risk to patients who receive medical implants, and can often lead implant failure, tissue necrosis, even amputation. So far, although various surface modification approaches proposed for prevention treatment of microbial biofilms on indwelling devices, most too expensive/complicated fabricate, unscalable, or limited in durability clinical use. Here, this work presents new bottom‐up design fabricating scalable durable nano‐patterned coatings with dynamic...
In the era of precision oncology, multicolor fluorescence imaging has become a core technology for multiplexed molecular analysis cellular and tissue specimens. However, conventional solution-based staining is labor-intensive time-consuming requires considerable expertise to yield optimal results, which creates difficulties employing this in resource-limited settings. Here, we report new immunostaining method based on hydrogel stamping, simple, fast, easy use, reproducible. We showed that...
We developed an integrated Hall magnetometer to measure magnetic properties in small sample volumes.
A lab-on-fiber (LOF) optofluidic platform that provides physiologically relevant microenvironment was developed by integrating a long period grating (LPG) coupled with high order cladding mode to achieve index sensitivity and liquid-tight capillary tube assembly as microfluidic chamber for LPG mimic microenvironment. We demonstrate the utility of LOF in situ monitoring construction [chitosan (CHI)/poly (acrylic acid) (PAA)/gentamicin sulfate (GS)/PAA]n multilayers at monolayer resolution...
ABSTRACT Lens-free digital in-line holography (LDIH) is a promising microscopic tool that overcomes several drawbacks (e.g., limited field of view) traditional lens-based microcopy. However, extensive computation required to reconstruct object images from the complex diffraction patterns produced by LDIH, which limits LDIH utility for point-of-care applications, particularly in resource settings. Here, we describe deep transfer learning (DTL) based approach process context cellular analyses....
Responsive polymer thin films play an important role as structural components in the emerging fields of soft actuators, wearable electronics, and biomedical devices. These are capable changing their physical and/or chemical properties significantly response to environmental stimuli, such temperature, light, pH, magnetic fields, ion strength. The integration multifunctional designs networks enables these possess advanced capabilities, including, but not limited to, structure color,...