This study was conducted to determine the antioxidant capacity, immunomodulatory and lipid-lowering effects of spirulina in healthy elderly subjects document effectiveness as a functional food for elderly.A randomized double-blind, placebo-controlled performed. The were 78 individuals aged 60-87 years randomly assigned blinded fashion receive either or placebo. instructed consume placebo at home, 8 g/day, 16 consecutive weeks.In male subjects, significant plasma cholesterol-lowering effect...

Oxidative stress plays an important role in the pathogenesis of renal diseases such as diabetic nephropathy. The metabolism excessive intracellular glucose may involve a number processes. One consequence levels is increased rate oxidative phosphorylation under hyperglycemic conditions, whereas another increase to sorbitol by aldose reductase. In addition, hyperglycemia result activation NADPH oxidase, production superoxide anion, and hydrogen peroxide (H2O2). this report, we investigate...

Survival of the conceptus is dependent on continuous progesterone signaling in maternal decidua but how this achieved under conditions oxidative stress that characterize early pregnancy unknown. Using primary cultures, we show modest levels reactive oxygen species (ROS) increase sumoylation human endometrial stromal cells (HESCs), leading to enhanced modification and transcriptional inhibition receptor (PR). The ability ROS induce a sustained hypersumoylation response, or interfere with PR...

Vascular inflammation plays a key role in the pathogenesis and progression of atherosclerosis, main complication diabetes. The present study investigated whether an aqueous extract Portulaca oleracea (AP) prevents TNF-α-induced vascular inflammatory process human umbilical vein endothelial cell (HUVEC). stimulation TNF-α induced overexpression adhesion molecules affects molecule (VCAM)-1, intercellular (ICAM)-1 E-selectin for example. However, AP significantly suppressed over-expression...

It is not known if the incidences of autoimmune diseases are higher in individuals living with HIV infection or AIDS. Our study investigated among people HIV/AIDS (PLWHA) Taiwan during 2000-2012.The National Health Insurance Research Database was used to identify PLWHA. The incidence densities systemic and organ-specific were calculated, age-adjusted, sex-adjusted period-adjusted standardised rates (SIRs) obtained by using two million from general population as controls. To examine effects...

The burgeoning interest in natural components personal care products has led to significant research and development of ingredients such as plant extracts, antioxidants, peptides, probiotics. These have been recognized for their potential enhance skin health through various mechanisms, addressing consumer demand that are both effective benign. Plant known rich composition bioactive compounds, offer a myriad benefits including antioxidant, anti-inflammatory, antimicrobial properties, making...

The accumulation of uric acid, an end-product purine metabolism, is responsible for the many deleterious effects observed in gouty arthritis, including renal injury. Here, we present evidence that under conditions hyperuricemia (>10(-4) M acid) [(3)H]thymidine incorporation into primary proximal tubule cells (PTCs) inhibited, and delineate signaling pathways involved. Elevated acid was to stimulate MAPK phosphorylation. induced p38 phosphorylation also blocked by H-7 (a PKC inhibitor),...

Recruitment of specific leukocyte subpopulations at the site inflammation requires a series cell adhesion molecules (CAMs)-mediated interactions. The major CAMs, viz., intracellular molecule-1 (ICAM-1), vascular (VCAM-1), and E-selectin are expressed on endothelium in response to various cytokines. Caffeic acid (CA), natural phenolic compound from herbs other sources, has been shown prevent cardiovascular diseases. We investigated effect CA expression CAMs by human umbilical vein endothelial...

Differentiation of human endometrial stromal cells into specialized decidual is critical for embryo implantation and survival the conceptus. Initiation this differentiation process strictly dependent on elevated cAMP levels, but signal intermediates that control expression marker genes, such as prolactin (PRL) IGFBP1, remain poorly characterized. Here we show cAMP-dependent decidualization can be attenuated or enhanced upon treatment primary cultures with a nicotinamide adenine dinucleotide...

Type 2 diabetes is associated with significantly accelerated rates of micro- and macrovascular complications such as diabetic vascular inflammation endothelial dysfunction. In the present study, we investigated protective effect aqueous extract Portulaca oleracea L. (AP), an edible plant used a folk medicine, on complications. The db/db mice were treated AP (300 mg/kg/day, p.o.) for 10 weeks, treatment markedly lowered blood glucose, plasma triglyceride, level LDL-cholesterol, systolic...

Morus alba L. has been used in traditional Chinese medicine and almost all parts of this plant are useful cardiovascular, liver spleen disorders. The present study was designed to investigate the inhibitory effect a water extract from (WMA) on vascular dysfunction rat models fed high fat cholesterol diet. Male rats were an atherogenic diet consisting food with 7.5% cocoa butter 1.25% cholesterol, or without 100 200 mg/day/kg WMA, for 14 weeks. Chronic treatment low (100 mg/kg/day) (200...

Abstract As recent advancements in the chimeric antigen receptor-T cells have revolutionized way blood cancers are handled, potential benefits from producing off-the-shelf, standardized immune entail need for development of allogeneic cell therapy. However, host rejection driven by HLA disparity adoptively transferred T remains a key obstacle to universal donor To evade HLA-mediated rejection, we attempted eliminate cell’s through CRISPR/Cas9 gene editing system. First, screened 60 gRNAs...

Abstract All‐solid‐state batteries (ASSBs) are promising “beyond lithium‐ion batteries” candidates owing to their high energy density and safety. Anodeless electrodes critical components for enabling these attributes, offering a fundamentally distinct mechanism compared conventional anode systems. This unique of anodeless has garnered significant scientific interest prompted extensive research. Based on recent advancements, this perspective provides comprehensive insights into electrode...

The dried root of Sanguisorba officinalis L. (commonly known as Diyu) has been studied for its various pharmacological effects, including antibacterial, antitumor, antioxidant, and anti-inflammatory activities. In the present study, primary cultured vascular endothelial cells (HUVECs) isolated phenylephrine-precontracted rat thoracic aortic rings were examined to investigate possible mechanism a butanol extract Diyu (BSO) in relaxant effect. HUVECs treated with BSO produced significantly...

Abstract Kaposi’s sarcoma-associated herpes virus (KSHV) is a recently identified human γ2-herpesvirus associated with sarcoma, primary effusion lymphoma, and Castleman’s disease. We reasoned that CTL responses may provide host defense against this virus, consequently, KSHV have evolved strategies to evade the CTL-mediated immune surveillance. In study six B cell lines latently infected were found express reduced levels of HLA class I surface molecules compared transformed by related...

We examined the effect of EGF on proliferation mouse embryonic stem (ES) cells and their related signal pathways. increased [3H]thymidine 5-bromo-2'-deoxyuridine incorporation in a time- dose-dependent manner. stimulated phosphorylation receptor (EGFR). Inhibition EGFR tyrosine kinase with AG-1478 or herbimycin A, inhibition PLC neomycin U-73122, PKC bisindolylmaleimide I staurosporine, L-type Ca2+ channels nifedipine methoxyverapamil prevented EGF-induced incorporation. PKC-alpha, -betaI,...

Although the importance of estradiol-17β (E 2 ) in many physiological processes has been reported, to date no researchers have investigated effects E on embryonic stem (ES) cell proliferation. Therefore, present study, we examined effect DNA synthesis murine ES (ES-E14TG2a) cells and its related signaling pathways. The results this study show that (10 −9 M) significantly increased [ 3 H]thymidine incorporation at >4 h (>10 −12 induced an increase after 8-h incubation. Moreover, also...

Although appendiceal orifice inflammation (AOI) is frequently observed as a skip lesion of ulcerative colitis (UC), its clinical significance not clearly understood. We aimed to evaluate whether AOI associated with the course UC.Ninety-four patients newly diagnosed distal UC were prospectively enrolled at Asan Medical Center between March 1996 and October 2002. Clinical features colonoscopic findings during follow-up period analyzed in relation initial status.Forty-eight found be initially...

Purpose: The purpose of this study was to develop a Simulation-based Integrated Clinical Practice Program (SICPP) for nursing students and identify the effect program. Methods: A non-equivalent pre-post test quasi-experimental design used. One hundred thirty-one participated in with 69 experimental group 62 control group. We developed SICPP taking 3 hours per session, once week 10 weeks. Data were analyzed using SPSS 19.0 program descriptive statistics, <TEX>${\chi}^2$</TEX>-test,...

Aims: It is necessary to evaluate glucose variability and postprandial hyperglycemia in patients with well-controlled type 2 diabetes mellitus because of the limitations associated hemoglobin A1c (HbA1c) measurements. We evaluated parameters reflecting glycemic optimal HbA1c. Patients Methods: Thirty-nine HbA1c levels below 7% were recruited study. A continuous monitoring system (CGMS) was applied for two 72-h periods. 1,5-Anhydroglucitol (1,5-AG) fructosamine (FA) measured as variability....

Acute Drug-Induced Hepatitis Caused by AlbendazoleAlbendazole binds to parasite's tubulin inhibiting its glucose absorption.Its common adverse effects are nausea, vomiting, constipation, thirst, dizziness, headache, hair loss and pruritus.Although mainly metabolized in the liver, abnormal liver function tests were a rare effect during clinical trials we found no literature about albendazole-induced hepatitis requiring admission.This patient had previous history of albendazole ingestion 2002...