Type 2 diabetes is associated with significantly accelerated rates of micro- and macrovascular complications such as diabetic vascular inflammation endothelial dysfunction. In the present study, we investigated protective effect aqueous extract Portulaca oleracea L. (AP), an edible plant used a folk medicine, on complications. The db/db mice were treated AP (300 mg/kg/day, p.o.) for 10 weeks, treatment markedly lowered blood glucose, plasma triglyceride, level LDL-cholesterol, systolic...

Diabetic nephropathy is one of the most common microvascular complications diabetes and leading cause end-stage renal disease. In present study, we investigated renoprotective effect aqueous extract Portulaca oleracea (AP) on diabetic accelerated by fibrosis inflammation in type 2 db/db mice. The mice were treated with AP (300 mg/kg/day, p.o.) for ten weeks to examine long-term effects dysfunction. We found that treatment markedly lowered blood glucose 412 ± 11.4 mg/dl plasma creatinine...

Aquaporin‐2 (AQP2), a family of water channels, plays an important role in the urinary concentrating process and regulation balance kidney. The dried sclerotia Poria cocos Wolf (WPC) has been used for chronic edema nephrosis. This study was conducted to evaluate effects WPC on hypertonic stress (175 mM NaCl)‐induced AQP2 expression apoptosis murine inner medullary collecting duct cell line (mIMCD‐3). significantly attenuated hypertonicity‐induced protein mRNA levels blocked apical membrane...

Vascular inflammation is an important factor which can promote diabetic complications. In this study, the inhibitory effects of aqueous extract from Prunella vulgaris (APV) on high glucose (HG)-induced expression cell adhesion molecules in human umbilical vein endothelial cells (HUVEC) are reported. APV decreased HG-induced intercellular molecule-1 (ICAM-1), vascular (VCAM-1), and E-selectin. also dose-dependently inhibited HL-60 monocytic cells. suppressed p65 NF-κB activation HG-treated...

Glomerular fibrosis is caused by an accumulation of intercellular spaces containing mesangial matrix proteins through either diffused or nodular changes. Dianthus superbus has been used in traditional medicine as a diuretic, contraceptive, and anti-inflammatory agent. The aim this study was to investigate the effects superbus-EtOAc soluble fraction (DS-EA) on glomerular renal dysfunction, which implicated diabetic nephropathy human cells db/db mice. DS-EA administered mice at 10 50 mg/kg/day...

Respiratory exposure to Particulate matter (PM), including Diesel exhaust particulate (DEP), causes oxidative stress-induced lung inflammation. Especially, fine with an aerodynamic diameter less than 2.5 µm (PM2.5) is a serious air pollutant associated various health problems cardiovascular diseases. The present study aimed examine the inhibitory effect of Securiniga suffruticosa (S. suffruiticosa) on DEP and PM-induced Mice inhaled by using nebulizer chamber for two weeks. Treatment S....

Abstract The proliferation of vascular smooth muscle cells may perform a crucial role in the pathogenesis diabetic disease. principal objective this study was to determine effects betulinic acid (BA) on human aortic cell (HASMC) induced by high glucose (HG). In study, [ 3 H]‐thymidine incorporation under 25 mM HG accelerated significantly as compared with 5.5 glucose, and increase inhibited BA treatment. We utilized Western blotting analysis evaluate cell‐cycle regulatory proteins....

Metabolic syndrome including obesity, dyslipidemia and hypertension is a cluster of risk factors cardiovascular disease. Fermentation medicinal herbs improves their pharmacological efficacy. Red ginseng (RG), widely used traditional herbal medicine, was reported with anti-inflammatory anti-oxidant activity. Aim in the present study to investigate that effects fermented red (FRG) on high-fructose (HF) diet induced metabolic disorders, those were compared RG losartan. Animals divided into four...

Nephrotic syndrome, a kidney disease with variety of causes, is mainly characterized by heavy proteinuria, hypoproteinemia, and ascites. This study was designed to evaluate the underlying mechanism action Plantago asiatica L. (PAL) in treating nephrotic syndrome induced puromycin aminonucleoside.PAL has been used Asia as traditional medicine dietary health supplement. Sprague-Dawley (SD) rats were intravenously injected aminonucleoside (75 mg/kg/day), then treated either Losartan (30...

Cardiac hypertrophy is a major risk factor for heart failure and leads to cardiovascular morbidity mortality. Doxorubicin (DOX) regarded as one of the most potent anthracycline antibiotic agents; however, its clinical usage has some limitations because it serious cardiotoxic side effects such dilated cardiomyopathy congestive failure. Betulinic acid (BA) pentacyclic-cyclic lupane-type triterpene that been reported have anti-bacterial, anti-inflammatory, anti-vascular neogenesis,...

Vascular inflammation process has been suggested to be an important risk factor in the initiation and development of atherosclerosis. In this study, we investigated whether by what mechanisms aqueous extract Buddleja officinalis (ABO) inhibited expressions cellular adhesion molecules, which are relevant Pretreatment human umbilical vein endothelial cells (HUVEC) with ABO (1–10 μg/ml) for 18 hours dose-dependently TNF-α-induced U937 monocytic cells, as well mRNA protein vascular cell...

Diabetes mellitus is the leading cause of vascular complications such as atherosclerosis. This study was designed to investigate whether Prunella vulgaris (APV) would inhibit diabetic atherosclerosis in db/db mice with type 2 diabetes. The were treated high fat/high cholesterol (HFHC) diet and an aqueous extract APV (100 200 mg/kg/day) for eight weeks examine long-term effect on metabolic abnormalities treatment markedly lowered blood glucose systolic pressure. experienced increase urea...

Abnormal and excessive growth of mesangial cells is important in the pathophysiologic processes diabetes-associated interstitial fibrosis glomerulosclerosis, leading to diabetic nephropathy, which eventually turns into end-stage renal disease. Sauchinone, a biologically-active lignan isolated from aerial parts Saururus chinensis, has anti-inflammatory anti-viral activities effects on various cell types. However, there are no studies reporting sauchinone nephropathy. The present study aims...

Abstract Vascular inflammation is involved in the initiation and progression of vascular diseases including atherosclerosis. While conducting vitro screening 600 medicinal plant extracts, an aqueous extract Thuja orientalis (ATO) was found to exhibit antiinflammatory activity human umbilical vein endothelial cells (HUVEC). In current study, ATO possible mechanisms for this were investigated HUVEC. Preincubation with (20 μg/mL) suppressed tumor necrosis factor‐α (TNF‐α)‐induced expression...

Diabetic nephropathy is characterized by renal hardening and interstitial fibrosis caused extracellular matrix (ECM) accumulation. The most distinctive diabetic lesion in the glomeruli mesangial expansion hyperplasia, which ultimately leads to nephrosclerosis. Oryeongsan (ORS), a traditional Chinese herbal medication, widely used treat nephrosis, dropsy, uremia. In this study, type 2 animals (db/db mice) were administered ORS (100 mg/kg/day) for 8 weeks examine potential beneficial effects...

The abnormal proliferation of vascular smooth muscle cells (VSMCs) in arterial walls is an important pathogenic factor disorders such as diabetic atherosclerosis. We have reported the anti-inflammatory effect aqueous extract from Prunella vulgaris (APV) endothelial cell. In present study, APV exhibited inhibitory effects on high glucose-stimulated VSMC proliferation, migration, and invasion activities, inducing G1 cell cycle arrest with downregulation cyclins CDKs upregulation CKIs,...

Diabetic nephropathy is both the most common complication and leading cause of mortality associated with diabetes. Prunella vulgaris, a well-known traditional medicinal plant, used for cure abscess, scrofula, hypertension urinary diseases. This study confirmed whether an aqueous extract vulgaris (APV) suppresses renal inflammation fibrosis. In human mesangial cell (HMC), pretreatment APV attenuated 25[Formula: see text]mM HG-induced suppressed TGF-[Formula: text] Smad-2/4 expression; it...

Gynura divaricata (L.) DC (Compositae) (GD) could be found in various parts of Asia. It has been used as a traditional medicine to treat diabetes, high blood pressure, and other diseases, but its effects have not yet scientifically confirmed. Therefore, we aimed at determining whether GD affect renal function regulation, the renin-angiotensin-aldosterone system (RAAS). Cardio-renal syndrome (CRS) is disease caused by interaction between kidney cardiovascular system, where acute or chronic...