A5054401681- Heart Failure Treatment and Management
- Cardiac electrophysiology and arrhythmias
- Renin-Angiotensin System Studies
- Nitric Oxide and Endothelin Effects
- Ion channel regulation and function
- Hormonal Regulation and Hypertension
- Receptor Mechanisms and Signaling
- Cardiac Arrhythmias and Treatments
- Peptidase Inhibition and Analysis
- Atrial Fibrillation Management and Outcomes
- Sexual function and dysfunction studies
- Neuropeptides and Animal Physiology
- Natural product bioactivities and synthesis
- Pulmonary Hypertension Research and Treatments
- Phosphodiesterase function and regulation
- Urinary Bladder and Prostate Research
- Cardiac Ischemia and Reperfusion
- Ion Transport and Channel Regulation
- Physiological and biochemical adaptations
- Thermoregulation and physiological responses
- Traditional Chinese Medicine Analysis
- Cardiovascular Function and Risk Factors
- Antioxidant Activity and Oxidative Stress
- Apelin-related biomedical research
- Traditional and Medicinal Uses of Annonaceae
Wonkwang University
2013-2024
Shandong First Medical University
2019-2023
Taishan Medical University
2007-2017
Jeonbuk National University
2003-2016
Institute for Atherosclerosis Research
2010
Chonbuk National University Hospital
2002-2003
Pohang University of Science and Technology
2003
Jeonju University
1999
Chonnam National University
1994
University of Massachusetts Chan Medical School
1991
To investigate the presence of C-type natriuretic peptide 1-22 (CNP)-dependent guanylyl cyclase (GC)-coupled receptor and its biological function in penile erectile smooth muscle.Experiments have been done rabbit rat to detect cyclic GMP (cGMP) generation by activation particulate GC peptides (NPs) cavernosal membrane, localize precise using a quantitative vitro autoradiography snap frozen sections, define (NPR) mRNA reverse transcriptase-polymerase chain reaction (RT-PCR) technique monitor...
No AccessJournal of UrologyInvestigative Urology1 Aug 1997Renin Angiotensin System in Rabbit Corpus Cavernosum: Functional Characterization II Receptors Jong Kwan Park, Sung Zoo Kim, Suhn Hee Young Kyung and Woo Cho ParkJong Park , KimSung Kim KimSuhn ParkYoung ChoKyung View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)64577-4AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: The...
The purpose of the present experiments was to define role C-type natriuretic peptide (CNP) in regulation atrial secretion (ANP) and stroke volume. Experiments were performed perfused beating nonbeating quiescent atria, single myocytes, membranes. CNP suppressed a dose-related fashion increase volume ANP induced by pacing. caused right shift positive relationships between changes or translocation extracellular fluid (ECF), which indicates suppression myocytic release into paracellular space....
This study tests the hypothesis that particulate (p) guanylyl cyclase (GC) and soluble (s) GC are involved in distinct roles for regulation of cGMP-PDE-cAMP signaling mechanical secretory functions heart. Experiments were performed perfused beating rabbit atria. C-type natriuretic peptide (CNP) SIN-1, an NO donor, or BAY 41-2272 (BAY), a direct activator sGC, used to activate pGC respectively. CNP SIN-1 increased cGMP cAMP efflux concentration-dependent manner. Increase was function cGMP....
Natriuretic peptide (NP) receptors (NPRs) located at the endocardial endothelium are suggested to be involved in regulating myocardial contractility. However, characteristics and modulation of NPRs relation cardiac failure not well defined. This study examined properties ventricular endocardium using quantitative receptor autoradiography, RT-PCR, Southern blot analysis, activation particulate guanylyl cyclase (GC) by NPs. In control rats, specific 125 I-labeled rat atrial NP (rANP)(1–28)...
Regulation of atrial release natriuretic peptide (ANP) is coupled to changes in dynamics. However, the mechanism by which mechanical stretch controls myocytic ANP must be defined. The purpose this study was define cAMP perfused, beating rabbit atria. cAMP-elevating agents forskolin and 3-isobutyl-1-methylxanthine (IBMX) inhibited release. activation adenylyl cyclase with release, a function an increase production. Inhibitors for L-type Ca(2+) channels protein kinase A (PKA) attenuated minor...
Atrial secretion of atrial natriuretic peptide (ANP) has been shown to be regulated by workload. Although modulating factors for the ANP have reported, role intracellular Ca 2+ on controversial. The purpose present study was define roles L- and T-type channels in regulation perfused beating rabbit atria. BAY K 8644 (BAY K) increased stroke volume pulse pressure. suppressed concentration terms extracellular fluid (ECF) translocation concomitantly with an increase dynamics. shifted...
Abstract The effects of synthetic atrial natriuretic peptide and turtle extract on cardiovascular renal functions were examined in the freshwater turtle, Amyda japonica . Both atrium ventricle heart contained an immunoreactive peptide. Synthetic rat (atriopeptin III) caused a dose‐dependent decrease mean arterial blood pressure. In turtles that received either atriopeptin III or extract, no significant changes function observed. However, furosemide was effective altering function. Levels...
We have previously shown that extracellular fluid (ECF) is translocated by atrial contraction. Following on from this finding we proposed a two‐step sequential mechanism for the regulation of stretch‐activated secretion natriuretic peptide (ANP): myocytic release ANP into surrounding paracellular space followed translocation ECF with released bloodstream. This latter step induced contraction, and therefore controlled workload. However, regulates changes in has not been defined. To define...
Lysophosphatidylcholine (LPC) is an endogenous phospholipid released from the cell membrane during ischemia, and it has potent, local effects on cardiac tissues. LPC been implicated in arrhythmogenesis ischemia by increasing intracellular Ca2+. However, not known whether influences atrial release of natriuretic peptide (ANP). The aim this study was to investigate effect ANP secretion isolated, perfused, beating rat atria. (10 30 micromol/L) caused decreases a dose-dependent manner, with...