A5016329074- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Bone Tissue Engineering Materials
- Nanoplatforms for cancer theranostics
- Advancements in Battery Materials
- Cancer Research and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Gas Sensing Nanomaterials and Sensors
- Luminescence and Fluorescent Materials
- Industrial Automation and Control Systems
- BIM and Construction Integration
- Molecular Sensors and Ion Detection
- Grouting, Rheology, and Soil Mechanics
- 3D Printing in Biomedical Research
- Corrosion Behavior and Inhibition
- Structural Engineering and Vibration Analysis
- QR Code Applications and Technologies
- Advanced Manufacturing and Logistics Optimization
- Bone Metabolism and Diseases
- Titanium Alloys Microstructure and Properties
- Graphene and Nanomaterials Applications
- Cancer-related Molecular Pathways
- ZnO doping and properties
- Cancer-related molecular mechanisms research
China Tobacco
2012-2025
China Construction Bank
2024
Shanghai Ninth People's Hospital
2017-2023
Shanghai Jiao Tong University
2010-2023
China Construction Eighth Engineering Division (China)
2023
The First People's Hospital of Tianmen
2019
Stomatology Hospital
2018
Qidong Liver Cancer Prevention Research
2011-2018
Beijing Institute of Geology for Mineral Resources
2014
China Geological Survey
2014
We followed 145 men with chronic hepatitis B virus (HBV) for 10 years to determine whether exposure aflatoxin, or concomitant C (HCV), family history of hepatocellular carcinoma (HCC) increased the risk developing HCC. collected 8 monthly urine samples before beginning follow-up and pooled them detect aflatoxin metabolite M1 (AFM1). AFM1 was detected in 78 (54%) subjects. The HCC 3.3-fold (with a 95% confidence interval 1.2-8.7) those detectable (above 3.6 ng/L). This relative adjusted age...
Background: Treatment of large bone defects represents a major clinical problem worldwide.Suitable substitute materials are commonly required to achieve successful regeneration, and much effort has been spent optimize their chemical compositions, 3D architecture mechanical properties.However, material-immune system interactions increasingly being recognized as crucial factor influencing regeneration.Here, we envisioned an accurate proactive immunomodulation strategy via delivery IL-4 (key...
In this work, we report a mild and cost-effective solution method to directly grow Ni-substituted Co3O4 (ternary NiCo2O4) nanorod arrays on Cu substrates. Electrochemical impedance spectroscopy (EIS) measurements show that the values of electrolyte resistance Re charge-transfer Rct NiCo2O4 are 6.8 63.5 Ω, respectively, which significantly lower than those binary (10.4 122.4 Ω). This EIS characterization strongly confirms ternary anode has much higher electrical conductivity electrode...
Exploring high performance cathode materials is essential to realize the adoption of Li-ion batteries for application in electric vehicles and hybrid vehicles. FeF3, as a typical iron-based fluoride, has been attracting considerable interest due both electromotive force value 2.7 V theoretical capacity 237 mA h g−1 (1e− transfer). In this study, we report facile low-temperature solution phase approach synthesis uniform iron fluoride nanocrystals on reduced graphene sheets stably suspended...
Biomaterial-based bone graft substitute with favorable mechanical and biological properties could be used as an alternative to autograft for large defect treatment. Here, apatite–collagen–polycaprolactone (Ap-Col-PCL) composite construct was developed unique nano–micro–macro hierarchical architectures by combining rapid prototyping (RP) fabrication technology a 3D functionalization strategy. Macroporous PCL framework fabricated using RP technology, then functionalized collagen incorporation...
Abstract Persistent bacteria, such as intracellular and biofilm are critical challenges in clinic treatment because they refractory to antibiotics management under the shelter of cytomembrane biofilm. Conventional strategies combat bacteria using high doses antibiotics, which may bring risk drug resistance, debridement increases patients’ pain economic burden. Currently, use is irreplaceable it necessary develop new enable common penetrate biofilm, then kill bacteria. Hence, a nanoscale...
In order to improve the palletising efficiency of robotic arm, a lightweight design is carried out for connecting beam, which heavier than end actuator (flexible suction cup). The three-dimensional model beam built in SolidWorks imported into abaqus static analysis and topology optimisation using Tosca module, optimised results are fe-safe fatigue analysis, redesign parts structure with higher stresses smallest life. maximum stress minimum life final significantly improved, mass finally...
Addressing the insufficient monitoring in tobacco logistics automation workshops that results suboptimal production efficiency and operational control challenges, this study proposes a process-centric visualization methodology. Through systematic modeling of cyber-physical interactions, we have: (1) Developed digital twin framework incorporating multi-dimensional mapping mechanisms spanning equipment states (vibration 2.3μm, temperature 45±2°C) workflows; (2) Established data ontology model...
To address the challenges posed by large sorting volume of cigarettes in tobacco logistics distribution centers and significant impact cigarette specification allocation on overall processing time orders, this study aims to optimize each zone enhance efficiency. A mathematical model is developed with objective minimizing similarity coefficients specifications within zone, which then solved using an enhanced genetic particle swarm dynamic clustering (GA-PSO-K) algorithm. Initially,...
Abstract Dynamic metabolomics studies can provide a systematic view of the metabolic trajectory during disease development and drug treatment reveal nature biological processes at level. To extract important information in time dimension rather than isolated points, weighted method based on means variations along points was proposed first applied to previously published rat model data. The subsequently extended prospective data analysis hepatocellular carcinoma (HCC). Permutation employed...
Antibiotics are among the most used weapons in fighting microbial infections and have greatly improved quality of human life. However, bacteria can eventually evolve to exhibit antibiotic resistance almost all prescribed drugs. Photodynamic therapy (PDT) develops little has become a promising strategy bacterial infection. To augment killing effect PDT, conventional is introducing excess ROS various ways, such as applying high light doses, photosensitizer concentrations, exogenous oxygen. In...
Bone tissue engineering is not widely used in clinical treatment. Two main reasons hide behind this: (1) the seed cells are difficult to obtain and (2) process of bone construction too complex its efficiency still relatively low. It foreseeable that near future, problem cell sources could be solved completely repair. As for low construction, usually two strategies would considered: strategy based on injectable osteogenic sheets. However, application (iBTE) sheet limited they hardly directly...
Raman measurements have been performed on ZnO bulk materials implanted with 220keV Mn+ ions various doses from 1015to1017cm2. The results reveal two modes at about 230 and 523cm−1, respectively, which are not observed in unimplanted ZnO. One mode 230cm−1 is assigned to the acoustic-phonon branch zone boundary. Another 523cm−1 attributed Zn-related vibration due Mn incorporation. By using a real-space recursion method, theoretical calculation indicates that originates of Zn atom surrounded...
Abstract Background: Mutations in the hepatitis B virus (HBV) genome may influence activity of liver disease. The aim this study was to identify new viral variations associated with hepatocellular carcinoma (HCC). Methods: We carried out a comparison on complete sequence HBV isolated from 20 HCC and 35 non-HCC patients Qidong, China, an area high incidence HCC. compared sequences consecutive series plasma samples four cases before after occurrence In addition, we selected mutations core (C)...
Although biomedical implants have been widely used in orthopedic treatments, two major clinical challenges remain to be solved, one is the bacterial infection resulting biofilm formation, and other aseptic loosening during implantation due over-activated osteoclastogenesis. These factors can cause many issues even lead implant failure. Thus, it necessary endow with antibiofilm loosening-prevention properties, facilitate integration between bone tissues for successful implantation. To achieve...
This study aimed to investigate the radiosensitizing effect of polydatin (PD) on colorectal cancer (CRC) and its underlying mechanism.The C57BL/6 mouse model CRC was induced by treatment with azoxymethane (AOM)/dextran sodium sulfate (DSS) then divided into four groups: control, PD alone, IR combination IR.Radiation therapy (200 cGy/min, 10Gy) performed in mice experimental groups for once a week total times.Thirty minutes before IR, were intraperitoneally injected at dose 25mg/kg.The number...
Conditioned media (CM) from mesenchymal stem cells (MSCs) contains various cytokines, growth factors and microRNAs, which may serve important roles in modulating the inflammatory process. However, effect of MSC‑CM on bone loss remains unknown. The present study investigated effects conditioned human adipose‑derived (AMSC‑CM) prevention lipopolysaccharide (LPS)‑mediated mice. To investigate underlying mechanisms this effect, AMSC‑CM serum levels inflammation‑associated cytokines [tumor...
Background/Aim Hepatitis B Virus (HBV) mutations play a role in the development of hepatocellular carcinoma (HCC). However, association between HBV polymerase gene and HCC has not been reported. In this study, we conducted multi-stage study to identify HCC-related reverse transcriptase (RT) domain gene. Methods A total 231 HCCs 237 non-HCC controls from Qidong, China, were included study. The entire sequence RT was first compared 29 35 cases, candidate then evaluated two independent...