A5100365740- Osteoarthritis Treatment and Mechanisms
- Systemic Lupus Erythematosus Research
- GDF15 and Related Biomarkers
- Inflammatory mediators and NSAID effects
- Sperm and Testicular Function
- Pregnancy and Medication Impact
- Bone and Dental Protein Studies
- Nerve injury and regeneration
- Genetic Associations and Epidemiology
- Ovarian cancer diagnosis and treatment
- Infant Nutrition and Health
- Reproductive System and Pregnancy
- Liver Diseases and Immunity
- Healthcare and Venom Research
- Genomics, phytochemicals, and oxidative stress
- Bone and Joint Diseases
- Traditional Chinese Medicine Studies
- Electrospun Nanofibers in Biomedical Applications
- Autoimmune and Inflammatory Disorders Research
- Botulinum Toxin and Related Neurological Disorders
- Reproductive Biology and Fertility
- Connective tissue disorders research
- Biosensors and Analytical Detection
- Hereditary Neurological Disorders
- Intracerebral and Subarachnoid Hemorrhage Research
Zhongda Hospital Southeast University
2022-2023
First Hospital of China Medical University
2023
Meizhou City People's Hospital
2015-2023
Academy of Medical Sciences
2023
Thermo Fisher Scientific (China)
2023
Simcere Pharmaceutical (China)
2022
First Hospital of Jilin University
2021
Jilin University
2021
Sun Yat-sen University
2015-2021
Hospital of Stomatology, Sun Yat-sen University
2021
Currently, the association between smoking, alcohol, and coffee intake risk of ovarian cancer (OC) remains conflicting. In this study, we used a two-sample mendelian randomization (MR) method to evaluate drinking consumption with OC prognosis.Five factors related lifestyles (cigarettes per day, smoking initiation, cessation, alcohol consumption) were chosen from Genome-Wide Association Study, 28, 105, 10, 36 single-nucleotide polymorphisms (SNPs) obtained as instrumental variables (IVs)....
Aim The purpose of this study was to gain a better understanding systemic lupus erythematosus (SLE) in Hakka populations. Methods We studied the demographic, clinical and laboratory characteristics cohort 552 SLE patients diagnosed at Rheumatology Department MeiZhou People's Hospital from January 2008 December 2012. There were 495 women 57 men (8.7 : 1) with mean age 35.3 years (range 12–78 years). disease onset duration 31.8 ± 14.4 3.3 2.8 years, respectively. Results most common...
Cholera toxin B subunit (CTB) has been extensively used in the past for monosynaptic mapping. For decades, it was thought to lack ability of transneuronal tracing. In order investigate whether biotin conjugates CTB (b-CTB) would pass through transneurons rat spinal cord, injected into crushed left sciatic nerve. experimental control, first afferent neuronal projections were defined by retrograde transport fluorogold (FG, a non-transneuronal labeling marker as an control) right nerve same...
Background: Breast cancer risk increases during pregnancy and remains elevated for a number of years thereafter. Cancer-associated proteins that are secreted into breast milk may provide means to detect in the lactating or assess future risk. Objective: To determine whether linked would be differentially expressed matched (both breasts from each participant) human samples collected women with unilateral cancer. Methods: Five cancer-associated (basic fibroblast growth factor [bFGF], YKL-40,...
Abstract Purpose Nowadays, there is no clinically applicable biomarker for osteoarthritis (OA). Therefore, the aim of study to discover a potential OA. Experimental Design We performed proteomics eight cartilage samples (four damaged and four macroscopically intact cartilage) from OA patients without any comorbidities search valuable biomarkers. Four rats underwent bilateral ovariectomy induce (OVX‐OA) model, while another sham procedure wherein ovaries were exteriorized but not removed...
Abstract Background The Wnt planar cell polarity (PCP) pathway is implicated in osteoarthritis (OA) both animals and humans. Van Gogh-like 2 (Vangl2) a key PCP protein that required for the orientation alignment of chondrocytes growth plate. However, its functional roles OA still remain undefined. Here, we explored effects Vangl2 on chondrocyte vitro further elucidated molecular mechanism silencing Wnt5a-overexpressing chondrocytes. Methods Chondrocytes were treated with IL-1β (10 ng/mL) to...
The total bile acid (TBA) concentration criterion for diagnosing intrahepatic cholestasis of pregnancy varies in the published literature. purpose this study was to establish pregnancy-specific reference ranges TBA among Latina women.Self-identified women (n = 211) over 18 years age with a singleton were recruited and had random serum samples drawn during second third trimesters. fractionated concentrations analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS), calculated....
Breast cancer that develops during or shortly after pregnancy is frequently more aggressive than diagnosed at other times in a woman's life. To better understand the patterns of cancer-related protein expression breasts lactating women, we determined differences total and individual milk based on (a) three time points lactation (early, mid, late), (b) length lactation, (c) parity. Breastmilk was collected from 72 healthy women within 10 days starting (transitional [T]), 2 months started,...
Objective: The aim of this study was to explore the longitudinal associations stroke with cognitive impairment in older US adults. Method: data used analysis were extracted from National Health and Aging Trends Study (NHATS) 2011 2019. Univariate multivariable Cox proportional hazards regression models estimate association impairment. model adjusted by demographic, physical, mental characteristics, complex survey design NHATS taken into consideration. Results: A total 7,052 participants...
DNA detection, which includes the measurement of variants in sequences or presence certain genes, is widely used research and clinical diagnosis. Both require DNA-dependent polymerase-catalyzed strand extension. Currently, these techniques rely heavily on instruments to visualize results. This study introduced a simple direct colorimetric method measure polymerase-directed elongation. First, pyrophosphate (PPi), by-product extension, converted into phosphate (Pi). Phosphate levels were...
To investigate the relationship between sperm acrosome reaction (AR) and clinical pregnancy rate of intrauterine insemination (IUI).We detected spontaneous AR Ca2+ ionophore A23187-induced in 128 patients who accepted IUI treatment, collected their data analysed IUI.There was no statistical difference rates pregnant group non-pregnant (7.7% vs. 7.0%, P>0.05), but there induced rates(51.9 % 43.5%, P<0.05). There among 3 groups divided by (≤20.0%, 20.1%-49.9%, ≥50.0%; 4.8% 12.5% 18.6%,...
This study aims to estimate predicted factors for maternal and fetal outcomes in Hakka pregnant women with systemic lupus erythematosus (SLE) the southern China.Between June 2014 February 2020, we retrospectively analyzed data of a total 123 singleton SLE (mean age: 27.1±4.1 years; range, 19 39 years) who were referred our rheumatology clinic. Demographic, clinical, laboratory patients recorded. Adverse pregnancy (APOs) assessed.Multivariate logistic regression analysis revealed that...
Abstract Objective: Currently, the association between smoking, alcohol, and coffee intake risk of ovarian cancer (OC) remains conflicting. In this study, we used a two-sample mendelian randomization (MR) method to evaluate drinking consumption with OC prognosis. Methods: Five factors related lifestyles (cigarettes per day, smoking initiation, cessation, alcohol consumption) were chosen from Genome-Wide Association Study, 28, 105, 10, 36 single-nucleotide polymorphisms (SNPs) obtained as...
Abstract Osteocalcin (OCN), as a characteristic protein expressed at the mature stage of osteoblasts, plays an important role in crosstalk within skeletal muscle system. Mature OCN is secreted out cell after carboxylation endoplasmic reticulum. According to degree carboxylation, it can be divided into carboxylated (cOCN) and undercarboxylated (ucOCN). The two forms proteins exhibit different biological activities, which make their functions more complex than those currently recognized. Many...