A5060463153- Osteoarthritis Treatment and Mechanisms
- Inflammatory mediators and NSAID effects
- Protease and Inhibitor Mechanisms
- Bone Metabolism and Diseases
- Cardiac Fibrosis and Remodeling
- Orthopaedic implants and arthroplasty
- Pregnancy and Medication Impact
- Pomegranate: compositions and health benefits
- Lymphadenopathy Diagnosis and Analysis
- Mycobacterium research and diagnosis
- Adipokines, Inflammation, and Metabolic Diseases
- Orthopedic Infections and Treatments
- Bone health and treatments
- Blood Coagulation and Thrombosis Mechanisms
- Lymphoma Diagnosis and Treatment
- Connective tissue disorders research
- Cancer-related molecular mechanisms research
- Bone fractures and treatments
- Cytokine Signaling Pathways and Interactions
- Garlic and Onion Studies
- Peroxisome Proliferator-Activated Receptors
- TGF-β signaling in diseases
- Rheumatoid Arthritis Research and Therapies
Peking University
2013-2025
Peking University Third Hospital
2013-2025
Ministry of Education of the People's Republic of China
2021-2025
Central Hospital of Zibo
2023
Peking University International Hospital
2021
Osteoarthritis (OA) of the knee joint is a prevalent disease that affects most aging individuals worldwide. An extract garlic oil, diallyl disulfide (DADS), reportedly protects chondrocytes in vitro, with limited data available on its vivo OA effects. We explored efficacy DADS ovariectomy (OVX)-induced rats. In this study, thirty-four female Sprague-Dawley rats were used. Twenty-three underwent bilateral OVX and remaining sham procedure. Six weeks post-surgery, five SHAM sacrificed. The...
Osteoarthritis (OA) is a prevalent debilitating whole-joint disorder. Currently, growing number of proteomic studies have been performed to evaluate molecular biomarkers in several tissues from OA patients; however, little known about the protein profiles subchondral bone OA. In this study, analysis was on patients with identify differentially expressed proteins (DEPs). Bioinformatics tools were used further investigate these DEPs. Thereafter, DEPs validated samples OA, as well bilateral...
Osteoarthritis (OA) is a joint disorder involving cartilage degeneration and subchondral bone sclerosis. The bone-cartilage interface implicated in OA pathogenesis due to its susceptibility mechanical biological factors. crosstalk between the underlying elevated multiple factors, such as increased vascularization, porosity, microcracks fissures. Changes osteochondral are traceable alterations chondrocytes cells (osteoblasts, osteocytes osteoclasts). phenotypes of these can change with...
Osteoarthritis (OA) is mostly considered not a simple cartilage degradation, but whole joint disorder, with all the components involved, such as subchondral bone, synovium and adhesive ligaments/muscles. Moreover, metabolic syndrome (MetS) OA are both share low-grade inflammatory state, an increasing number of studies have found correlations between OA. Their imply that might be also affected by MetS. MetS characterized series risk factors, including hypertension, hyperglycaemia,...
Background: Emerging knowledge has highlighted the role of matrix metalloproteinase (MMP)-13 in osteoarthritis (OA); however, suitability MMP-13 as a biomarker for OA remains unclear. Therefore, this study aimed to assess potential value OA. Methods: The enrolled 51 patients, which 33 had advanced varus and 18 did not have Immunohistochemistry western blotting analyses were performed measure activity cartilage subchondral bone patients with Enzyme-linked immunosorbent assay was used serum...
Background: Osteoarthritis (OA) is a whole-joint disease and characterized by alterations in the articular cartilage, subchondral bone, ligaments, synovial membrane. The crosstalk between cartilage bone plays crucial role pathogenesis progression of OA. Hypoxia has been reported to play an important degradation remodeling In this study, we aimed identify involvement hypoxia modifying osteoblast phenotypes determine whether these could influence metabolism chondrocytes. Methods: First, levels...
Introduction Different opinions exist about the role of subchondral bone in osteoarthritis (OA), probably because has different effects on cartilage degeneration OA induced by pathologies. Animal studies to illustrate were mostly based post-traumatic (PT-OA). Postmenopausal women experience a much higher occurrence than similar-aged men. The physiological changes and pathogenesis osteochondral unit ovariectomy-induced (OVX-OA) might be distinct from other types OA. Methods alterations...
Osteoarthritis (OA) is prevalent in postmenopausal women. Subchondral bone ovariectomized (OVX) rats might play a more important role cartilage degeneration compared with other types of OA. How subchondral osteoblast changes OVX still unclear. Understanding obtained from be helpful to clarify pathogenesis OVX-OA.Female Sprague-Dawley were randomly divided into two groups: Sham (n=20) and (n=20). Serum levels Alkaline phosphatase (ALP) C-telopeptide type I collagen (CTX-I) measured every one...
Abstract Purpose Nowadays, there is no clinically applicable biomarker for osteoarthritis (OA). Therefore, the aim of study to discover a potential OA. Experimental Design We performed proteomics eight cartilage samples (four damaged and four macroscopically intact cartilage) from OA patients without any comorbidities search valuable biomarkers. Four rats underwent bilateral ovariectomy induce (OVX‐OA) model, while another sham procedure wherein ovaries were exteriorized but not removed...
Abstract Background Emerging knowledge has highlighted the role of periostin (POSTN) in osteoarthritis (OA) process; however, whether POSTN is suitable as a biomarker OA remains unclear. This study aimed to investigate potential value OA. Methods Ten 6-month-old female Sprague–Dawley (SD) rats were used this study. Five underwent ovariectomy (OVX) operation and others carried out sham operation. Thirty-two patients with eighteen who had meniscus injuries or ligament but intact articular...
ABSTRACT Objective The clinical management of partial bone defects in lower limbs, particularly those resulting from osteomyelitis, remains a significant challenge. This study aimed to systematically evaluate the effectiveness 3D‐printed porous Ti6Al4V prostheses addressing osteomyelitis‐induced defects. Methods We established comprehensive protocol for utilizing defect repair, encompassing 3D simulation prosthesis implantation and internal fixation, finite element analysis (FEA),...
Osteoarthritis (OA) is a joint disease that leads to high disability rate and low quality of life. With the development modern molecular biology techniques, some key genes diagnostic markers have been reported. However, etiology pathogenesis OA are still unknown.To develop gene signature in OA.In this study, five microarray data sets were integrated conduct comprehensive network pathway analysis biological functions related genes, which can provide valuable information further explore...
Abstract Background: Emerging knowledge has highlighted the role of periostin (POSTN) in osteoarthritis (OA) process; however, whether POSTN is suitable as a biomarker OA remains unclear. Herein, we investigated potential value OA. Methods: We detected expression cartilage ovariectomy (OVX)-OA rats and different compartments knee joint patients with using immunohistochemistry examined serum levels or without enzyme-linked immunosorbent assay (ELISA). The associations among levels, clinical...