OBJECTIVE Postoperative neurological deficits are a significant concern for surgeons during spinal deformity correction surgery. Preoperative identification of high-risk patients can help ensure that appropriate measures taken to minimize the risk these procedures. Previous studies have shown with large Cobb angles or angular ratios (DARs) at higher postoperative deficits. However, some curves similar and DARs may exhibit significantly different risks Existing methods evaluating degree...

Retrospective review.To perform a single-institution analysis of incidence, treatment, and clinical outcome in patients with thoracic ossification the ligamentum flavum (OLF) who experienced dural tears cerebrospinal fluid (CSF) leakage.There is paucity reports focusing on CSF leakage after OLF surgery. Because adhesion are common features OLF, incidence high represents significant challenge.A total 266 were admitted to our hospital from 1995 2011. Each patient's medical records reviewed...

BackgroundScrophulariae Radix (SR) is a commonly used medicinal plant. Alzheimer's disease (AD) neurodegenerative for which there no effective treatment. This study aims to initially clarify the potential mechanism of SR in treatment AD based on network pharmacology and molecular docking techniques.MethodsThe principal components corresponding protein targets were conducted by HPLC analysis searched TCMSP. DrugBank, Chemogenomics, TTD, OMIM GeneCards databases. The compound-target was...

Abstract Background To analyze the effect of different types bone cement distribution after percutaneous vertebroplasty (PVP) in patients with osteoporotic vertebral compression fracture (OVCF). Methods One hundred thirty seven single level OVCF who underwent PVP were retrospectively analyzed. The divided into two groups according to distribution. Group A: contacted both upper and lower endplates; B: missed at least one endplate. B was 3 subgroups. B1: only B2: B3: located middle body....

Mini A total of 137 degenerative lumbar scoliosis patients were divided into two groups. In group (six or more fused levels), mean rFCSA erector spinae <0.71 was an independent risk factor LIV screw loosening. Group B (four five paraspinal muscle degeneration had no influence on Study Design. retrospective study. Objective. The aim this study to evaluate the effect muscles, including psoas and multifidus muscles pedicle loosening at lower instrumented vertebra (LIV) following corrective...

Intraoperative neuromonitoring (IONM) alerts are critical concerns for surgeons performing spinal deformity corrective surgeries, as they indicate a heighteded risk of postoperative neurological deficits. Previous studies have demonstrated that patients with large Cobb angle or elevated angular ratio (DAR) at an increased IONM alerts. However, curves similar angles and DARs may exhibit significantly different risks during surgery. Current methods evaluating fail to comprehensively accurately...

To address the challenges posed by ore grade fluctuations, extraction cost variations, and market price instability in open-pit production strategies, an optimization model integrating a solution algorithm dynamic simulation is proposed. First, Monte Carlo used to generate random variables, simulating fluctuations at different points. Then, Non-dominated Sorting Genetic Algorithm II with Grey Relational Analysis (NSGA-II-GRA) employed for initial obtain preliminary Pareto-optimal set....

Ossification of the ligamentum flavum (OLF) is a disorder heterotopic ossification spinal ligaments and main cause thoracic canal stenosis. Previous studies suggested that miR-132-3p negatively regulates osteoblast differentiation. However, whether involved in process OLF has not been investigated. In this study, we investigated effect its target genes forkhead box O1 (FOXO1), growth differentiation factor 5 (GDF5) SRY-box 6 (SOX6) on osteogenic (LF) cells. We demonstrated was down-regulated...

Background Icariine is a flavonoid isolated from traditional Chinese medicine Epimedium pubescens and the main active compound of it. Recently, was found to have therapeutic effect on osteoporosis. But mechanism unclear. The aim study research proliferation differentiation human osteoblasts. Methods Human osteoblasts were obtained by inducing marrow mesenchymal stem cells (hMSCs) directionally cultured in presence various concentrations Icariine....

Obesity is a risk factor for thoracic ossification of ligament flavum (TOLF) that characterized by ectopic bone formation in the spinal ligaments. Hyperleptinemia common feature obese people, and leptin, an adipocyte-derived cytokine with proliferative osteogenic effects several cell types, believed to be important pathogenesis TOLF. However, how leptin might stimulate differentiation TOLF not totally understood. We reported here leptin-induced effect cells associated activation signaling...

Thoracic ossification of the ligamentum flavum (TOLF) is characterized by ectopic bone formation in and considered to be a leading cause thoracic spinal canal stenosis myelopathy. However, underlying etiology not well understood. An iTRAQ proteomics was used reveal involvement inflammation factors TOLF. TNF-α pro-inflammatory cytokine implicated pathogenesis many human diseases. Protein profiling analysis showed that protein level increased ossified TOLF, which confirmed western blot. The...

Abstract Ossification of the ligamentum flavum (OLF) is a pathology almost only reported in East Asian countries. The leading cause OLF thoracic spinal canal stenosis and myelopathy. In this study, role miR‐199b‐5p jagged 1 (JAG1) primary cell osteogenesis was examined. MiR‐199b‐5p found to be down‐regulated during osteogenic differentiation cells, while overexpression inhibited differentiation. addition, JAG1 up‐regulated knockdown via RNA interference caused an inhibition Notch signalling...

Mechanical stress is considered to be an important factor in the progression of thoracic ossification ligament flavum (TOLF). To elucidate mechanism underlying mechanical stress-induced TOLF, we investigated effect stretching on cultured cells derived from TOLF and non-TOLF patients. We found that mRNA expression alkaline phosphatase (ALP), osteocalcin, Runx2, osterix, but not Dlx5 Msx2, was significantly increased by cells. In addition, seems finely tuned stretching-triggered activation...

Thoracic spinal stenosis is a relatively common disorder causing paraplegia in the population of C hina. Until nowadays, clinical management thoracic still demanding and challenging with lots questions remaining to be answered. A guideline for treatment symptomatic has been created by reaching consensus hinese specialists using best available evidence as tool aid practitioners involved care this disease. In guideline, many fundamental about which were controversial have explained clearly,...

Few studies have concentrated on the sagittal alignment of lumbar disc herniation (LDH), especially parameters pelvis, and controversy exists about whether pelvic morphology is involved in pathogenesis LDH. The present study analyzed characteristics young Chinese LDH patients explored impact LDH.A retrospective analysis was conducted 100 with (69 men 31 women, aged 18-35 years), clinical imaging findings met criteria for diagnosis control group included asymptomatic volunteers matching age...