A5084582850- Bone Metabolism and Diseases
- Osteoarthritis Treatment and Mechanisms
- Bone Tissue Engineering Materials
- Inflammatory mediators and NSAID effects
- Bone health and treatments
- Calcium Carbonate Crystallization and Inhibition
- Cytokine Signaling Pathways and Interactions
- Dental Implant Techniques and Outcomes
- 3D Printing in Biomedical Research
- Peroxisome Proliferator-Activated Receptors
- Magnesium Alloys: Properties and Applications
- Conducting polymers and applications
- Flame retardant materials and properties
- Connective tissue disorders research
- Electrospun Nanofibers in Biomedical Applications
- Spine and Intervertebral Disc Pathology
- Pomegranate: compositions and health benefits
- Advanced Proteomics Techniques and Applications
- Pregnancy and Medication Impact
- TGF-β signaling in diseases
- Garlic and Onion Studies
- Anesthesia and Pain Management
- Peptidase Inhibition and Analysis
- dental development and anomalies
Peking University
2017-2025
Peking University Third Hospital
2017-2025
Osteoarthritis (OA) of the knee joint is a prevalent disease that affects most aging individuals worldwide. An extract garlic oil, diallyl disulfide (DADS), reportedly protects chondrocytes in vitro, with limited data available on its vivo OA effects. We explored efficacy DADS ovariectomy (OVX)-induced rats. In this study, thirty-four female Sprague-Dawley rats were used. Twenty-three underwent bilateral OVX and remaining sham procedure. Six weeks post-surgery, five SHAM sacrificed. The...
To induce bone regeneration efficiently, a properly designed organic-inorganic composite scaffold is necessary and important. Gelatin-hydroxyapatite (HA) suitable choice for the purpose because it can resemble chemical composition of natural tissue. The gelatin-HA be implanted into defects as hydrogel or cryogel, however, interesting to know effect their different morphology on inducing osteogenesis in vivo. Herein, HA nanowire (HANW) reinforced photocrosslinkable methacrylated gelatin...
Osteoarthritis (OA) is a joint disorder involving cartilage degeneration and subchondral bone sclerosis. The bone-cartilage interface implicated in OA pathogenesis due to its susceptibility mechanical biological factors. crosstalk between the underlying elevated multiple factors, such as increased vascularization, porosity, microcracks fissures. Changes osteochondral are traceable alterations chondrocytes cells (osteoblasts, osteocytes osteoclasts). phenotypes of these can change with...
Introduction Different opinions exist about the role of subchondral bone in osteoarthritis (OA), probably because has different effects on cartilage degeneration OA induced by pathologies. Animal studies to illustrate were mostly based post-traumatic (PT-OA). Postmenopausal women experience a much higher occurrence than similar-aged men. The physiological changes and pathogenesis osteochondral unit ovariectomy-induced (OVX-OA) might be distinct from other types OA. Methods alterations...
Osteoarthritis (OA) is prevalent in postmenopausal women. Subchondral bone ovariectomized (OVX) rats might play a more important role cartilage degeneration compared with other types of OA. How subchondral osteoblast changes OVX still unclear. Understanding obtained from be helpful to clarify pathogenesis OVX-OA.Female Sprague-Dawley were randomly divided into two groups: Sham (n=20) and (n=20). Serum levels Alkaline phosphatase (ALP) C-telopeptide type I collagen (CTX-I) measured every one...
Nitazoxanide (NTZ) is an FDA-approved anti-parasitic drug with broad-spectrum anti-infective, anti-inflammatory, and antineoplastic potential. However, its regulatory effects on osteoclastogenesis the underlying mechanisms remain unclear. The present study found that NTZ potently inhibited osteoclast formation at early stage of receptor activator NF-κB ligand-induced in a concentration-dependent manner non-growth inhibitory concentration. suppressed actin ring decreased marker gene...
Osteoarthritis (OA) is a joint disease that leads to high disability rate and low quality of life. With the development modern molecular biology techniques, some key genes diagnostic markers have been reported. However, etiology pathogenesis OA are still unknown.To develop gene signature in OA.In this study, five microarray data sets were integrated conduct comprehensive network pathway analysis biological functions related genes, which can provide valuable information further explore...