A5070588571- Nutrition and Health in Aging
- Inflammatory Biomarkers in Disease Prognosis
- Adipokines, Inflammation, and Metabolic Diseases
- Body Composition Measurement Techniques
- Cancer, Lipids, and Metabolism
- Frailty in Older Adults
- Nutritional Studies and Diet
- Cancer Risks and Factors
- Additive Manufacturing and 3D Printing Technologies
- Metabolism, Diabetes, and Cancer
- Fluid Dynamics and Mixing
- Mesenchymal stem cell research
- Biomarkers in Disease Mechanisms
- Photopolymerization techniques and applications
- Acute Myeloid Leukemia Research
- Fluid Dynamics and Heat Transfer
- GDF15 and Related Biomarkers
- Immunotherapy and Immune Responses
- Liver Disease Diagnosis and Treatment
- Molecular Sensors and Ion Detection
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Diet and metabolism studies
- Covalent Organic Framework Applications
Beijing Shijitan Hospital
2022-2025
Capital Medical University
2022-2025
Leiden University
2023-2025
National Clinical Research Center for Digestive Diseases
2022-2025
Beijing Institute of Education
2021-2025
Centre for Human Drug Research
2023-2025
China International Science and Technology Cooperation
2022-2024
Central South University
2021-2024
Beijing Friendship Hospital
2024
Kavli Energy NanoScience Institute
2023-2024
Background Colorectal cancer (CRC) is among the most common malignant cancers worldwide, and its development influenced by inflammation, nutrition, immune status. Therefore, we combined C-reactive protein (CRP), albumin, lymphocyte, which could reflect above status, to be CRP-albumin-lymphocyte (CALLY) index, evaluated association with overall survival (OS) in patients CRC. Methods The clinicopathological laboratory characteristics of 1260 CRC were collected from Investigation on Nutrition...
Abstract Background Astrocytes are crucial regulators in the central nervous system. Abnormal activation of astrocytes contributes to some behavior deficits. However, mechanisms underlying effects remain unclear. Here, we studied A1 and their contribution murine Methods were induced by treatment with lipopolysaccharide (LPS) vitro. The functional phenotype was determined quantitative RT-PCR, ELISA, immunohistochemistry. To assess role vivo, mice injected intraperitoneally LPS. Then,...
The new C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index is an immune nutrition scoring system based on serum CRP) albumin, and lymphocyte counts. aim of this study was to verify the prognostic value CALLY in patients with gastric cancer evaluate superiority system.
The synthesis of crystalline polyphenylene covalent organic frameworks (COFs) was accomplished by linking fluorinated tris(4-acetylphenyl)benzene building units using aldol cyclotrimerization. structures the two COFs, reported here, were confirmed powder X-ray diffraction techniques, Fourier transform infrared, and solid-state 13C CP/MAS NMR spectroscopy. results showed that COFs porous chemically stable in corrosive, harsh environments for at least 1 week. Accordingly, postsynthetically...
Abstract Background Malnutrition is associated with poor overall survival (OS) in breast cancer patients; however, the most predictive nutritional indicators for prognosis of patients are not well-established. This study aimed to compare effects common on OS and refine existing indicators, thereby identifying a more effective evaluation indicator predicting patients. Methods prospective analyzed data from 776 enrolled “Investigation Nutritional Status its Clinical Outcome Common Cancers”...
Abstract Background The development and progression of cancer cachexia are connected to systemic inflammation physical performance. However, few relevant studies have reported the survival outcomes prediction performance in patients with colorectal (CRC) cachexia. This study investigated prognostic value status CRC Methods multicentre cohort prospectively collected 905 (58.3% males, 59.3 ± 11.5 years old). Cancer was diagnosed according 2011 Fearon Cachexia Diagnostic Consensus. systematic...
Importance The European Society for Clinical Nutrition and Metabolism (ESPEN) the Association Study of Obesity (EASO) have recently proposed a consensus definition diagnostic criteria sarcopenic obesity (SO). Objective To implement ESPEN-EASO algorithm to investigate prevalence SO its association with outcomes in patients solid tumor cancers, particular regard associations among SO, overall survival (OS), patient quality life (QoL). Design, Setting, Participants This prospective cohort study...
Neural stem cells (NSCs) are critical for brain development and maintenance of neurogenesis. However, the molecular mechanisms that regulate NSC proliferation differentiation remain unclear. Mysm1 is a deubiquitinase essential self-renewal several cells. It unknown whether plays an important role in NSCs. Here, we found was expressed NSCs its expression increased with age mice. Mice knockdown by crossing floxed mice Nestin-Cre exhibited abnormal microcephaly. deletion promoted apoptosis,...
Background: Diet quality significantly influences aging processes and age-related health outcomes. This study aims to explore the association between dietary accelerated in two large cohorts. Methods: collected data from Kailuan National Health Nutrition Examination Survey (NHANES) cohorts; participants' was evaluated using American Heart Association (AHA) score Healthy Eating Index-2015 (HEI-2015), respectively. Accelerated participants determined by calculating difference phenotypic age...
We have developed a polyethylenimine-functionalized covalent organic framework (COF) for capturing CO
Abstract Background The C-reactive protein (CRP)-triglyceride-glucose (TyG) index (CTI), which is a measure representing the level of inflammation and insulin resistance (IR), related to poor cancer prognosis; however, CTI has not been validated in patients with cachexia. Thus, this study aimed explore potential clinical value Methods In study, our prospective multicenter cohort included 1411 cachexia (mean age 59.45 ± 11.38, 63.3% male), was combined analysis multiple types. We randomly...
Abstract Background Breast cancer is the most common malignancy in women worldwide. The relationship between remnant cholesterol (RC) and prognosis of patients with breast has not been clearly reported. This study investigated prognostic value RC predicting mortality cancer. Methods prospectively analysed 709 from Investigation on Nutrition Status Clinical Outcome Common Cancers (INSCOC) project. Restricted cubic splines were used to analyse dose-response mortality. Kaplan–Meier method was...
The Asian Working Group for Cachexia (AWGC) proposed the first consensus report on diagnostic criteria cachexia in Asians 2023. However, current lacks cohort evidence to validate its effectiveness and practicality. We aimed explore value of AWGC2023 predicting prognosis medical burden patients with cancer through a retrospective post hoc cross-sectional analysis Investigation Nutrition Status Clinical Outcome Common Cancers (INSCOC) project China.
Interleukin-6 (IL-6) is a central factor linking inflammation to cancer. This study aimed provide comprehensive assessment of the prognostic value IL-6 and its immunotherapeutic features using population-based pan-cancer analysis bioinformatic analysis. In cohort study, 540 patients were included explore serum levels in The differential expression association with survival immune cell infiltration investigated TCGA database. SangerBox database was used analyze correlation between checkpoint...
Abstract The 3D human pituitary organoid represents a promising laboratory model for investigating diseases. Nonetheless, this technology is still in its nascent stage, with uncertainties regarding the cellular composition, intercellular interactions, and spatial distribution of organoids. To address these gaps, culture conditions are systematically adjusted efficiency induced pluripotent stem cells’ (iPSCs’) differentiation into organoids successfully improved, achieving results comparable...