A5101659363- Epilepsy research and treatment
- Receptor Mechanisms and Signaling
- Renin-Angiotensin System Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Dementia and Cognitive Impairment Research
- Neuropeptides and Animal Physiology
- Pharmacological Effects and Toxicity Studies
- Liver Disease Diagnosis and Treatment
- Technology Use by Older Adults
- Traumatic Brain Injury and Neurovascular Disturbances
- Atherosclerosis and Cardiovascular Diseases
- Cholesterol and Lipid Metabolism
- Health disparities and outcomes
- Lipoproteins and Cardiovascular Health
- Aging and Gerontology Research
- Cardiac Imaging and Diagnostics
- EEG and Brain-Computer Interfaces
- Drug Transport and Resistance Mechanisms
- Coronary Interventions and Diagnostics
- Chronic Kidney Disease and Diabetes
- Intracerebral and Subarachnoid Hemorrhage Research
- Chemokine receptors and signaling
- Cardiac Valve Diseases and Treatments
- Blood Pressure and Hypertension Studies
- Fuel Cells and Related Materials
Huazhong University of Science and Technology
2016-2025
Union Hospital
2017-2025
The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture
2021-2024
University of Utah
2024
Henan Provincial People's Hospital
2021
Zhengzhou University
2018-2021
Union Hospital
2012-2020
Singapore General Hospital
2020
Wuhan Union Hospital
2019
China Aerospace Science and Technology Corporation
2011
The Gpbar1 [G-protein-coupled BA (bile acid) receptor 1] is a recently identified cell-surface that can bind and activated by BAs, but its physiological role unclear. Using targeted deletion of the gene in mice, we show plays critical maintenance bile lipid homoeostasis. Mice lacking expression were viable, developed normally did not significant difference levels cholesterol, BAs or any other constituents. However, they form cholesterol gallstones when fed cholic acid-containing high-fat...
G-protein-coupled bile acid receptor 1 (GPBAR1/TGR5/M-Bar/GPR131) is a cell surface involved in the regulation of metabolism. We have previously shown that Gpbar1 -null mice are resistant to cholesterol gallstone disease when fed lithogenic diet. Other published studies suggested both energy homeostasis and glucose homeostasis. Here, we examine functional role diet-induced obese mice. found body weight, food intake, fasted blood levels were similar between their wild-type (WT) littermates...
Primary hypertension is a chronic disease with high morbidity, and the rate of controlled blood pressure far from satisfactory, worldwide. Vaccination provides promising approach for treatment improvement in compliance. Here, ATRQβ-001 vaccine, peptide (ATR-001) derived human angiotensin II (Ang II) receptor type 1 conjugated Qβ bacteriophage virus-like particles, was developed evaluated animal models hypertension. The vaccine significantly decreased Ang II-induced hypertensive mice up to 35...
Background Dementia poses a significant global health challenge, characterized by progressive cognitive decline and functional impairment. With the aging population, dementia prevalence is projected to surge, reaching an estimated 153 million cases 2050. While impact of traditional social isolation on risk has been extensively studied, influence digital isolation, phenomenon unique age, remains underexplored. Objective This study aimed investigate association between among older adults,...
<sec> <title>BACKGROUND</title> The rapid advancement of digital technologies has profoundly transformed communication practices. However, this technological revolution also led to "digital isolation," a form social disconnection caused by limited or absent engagement with tools, including smartphones, computers, email, and the internet. This issue is particularly concerning for older adults, as it may increase their risk mental health disorders, depression. Although isolation been studied...
<sec> <title>BACKGROUND</title> As digital technology becomes increasingly embedded in daily life, isolation among older adults has become more pronounced. This may restrict access to health information and social support, potentially leading poorer sleep quality. However, most existing studies on disorders are cross-sectional, lacking longitudinal evidence establish causality. </sec> <title>OBJECTIVE</title> study aimed investigate the association between using both cross-sectional designs,...
<sec> <title>BACKGROUND</title> The rapid advancement of digital technologies has profoundly transformed communication practices. However, this technological revolution also led to "digital isolation," a form social disconnection caused by limited or absent engagement with tools, including smartphones, computers, email, and the internet. This issue is particularly concerning for older adults, as it may increase their likelihood developing mental health disorders, depression being primary...
Recent work has shown that neuromedin U (NmU), a peptide initially identified as smooth muscle contractor, may play role in regulating food intake and energy homeostasis. To further evaluate this putative function, we measured intake, body weight, expenditure glucose homeostasis transgenic mice ubiquitously overexpress murine proNmU. NmU were lighter had less somatic liver fat, hypophagic, improved insulin sensitivity judged by an intraperitoneal tolerance test. Transgenic higher levels of...
Recently, our group has developed a therapeutic hypertensive vaccine against angiotensin (Ang) II type 1 receptor (AT1R) named ATRQβ-001. To explore its potential effectiveness on streptozotocin-induced diabetic nephropathy, male Sprague Dawley rats were randomly divided into two groups: control and model. After week, the four subgroups (each with 15 rats) for 14-week treatments saline, olmesartan, ATRQβ-001, Qβ virus-like particle (VLP), respectively. In addition to lower blood pressure,...
Background Defects in the renal fatty acid β‐oxidation pathway have been implicated development of fibrosis. Our group has developed a therapeutic vaccine targeting PCSK 9 (proprotein convertase subtilisin/kexin type 9), named 9Qβ‐003. In this study, we investigated potential effectiveness 9Qβ‐003 on hypercholesterolemia with Methods and Results The low‐density lipoprotein receptor +/− male mice fed high‐cholesterol (1%) Western diet were randomly assigned into 4 groups: sham (or control...
We developed a virus-like particle (VLP)-based therapeutic vaccine against angiotensin II receptor type 1, ATR-AP205-001, which could significantly reduce the blood pressure and protect target organs of hypertensive animals. In this study, we focused on immunological effect safety VLP-based vaccine. By comparing to depolymerized dimeric ATR-Dimer-001, found that ATR-AP205-001 reached subcapsular sinus lymph node shortly after administration, followed by accumulation follicle dendritic cells...
Objective: Angiotensin II (AngII) type 1 receptor (AT1R) blockers have been proved to reduce atherosclerosis. Previously, we invented ATRQβ-001 vaccine which showed a desirable blocking effect for AT1R. The purpose of this study was investigate whether would prevent atherosclerosis in apolipoprotein E-null (ApoE–/–) mice. Methods: Male ApoE–/– mice were administered with vaccine, Qβ virus-like particles, valsartan or vehicle over period 24 weeks. In vitro, human coronary artery endothelial...
The α1-AR (α1 adrenergic receptor) blockers currently on the market cannot meet clinical needs because of low-selectivity for subtypes α1-ARs, short half-life, and uncertain role in cardiovascular end point events. study sought to find a vaccine specifically against α1D-AR (α1D-adrenergic treating hypertension. A peptide ADR-004 (cgiteeagy) belonging was screened, ADRQβ-004 produced injected into spontaneously hypertensive rats model (including short-term study, 10 weeks, long-term...
Endothelial microparticles (EMPs) are small vesicular structures that serve as a marker of endothelial function. Angiotensin II receptor type 1 autoantibody (AT1-AA) can cause dysfunction. However, whether AT1-AA promotes EMPs formation and the mechanism remains obscure.The titres sera 126 hypertensive patients 30 normotensive individuals were evaluated by ELISA. in supernatants human umbilical vein cells (HUVECs) measured flow cytometry. The phosphorylation levels mitogen-activated protein...
Vaccination provides a promising approach for treatment of hypertension and improvement in compliance. As the initiation factor renin-angiotensin system, renin plays critical role hypertension. In this study, we selected six peptides (rR32, rR72, rR215, hR32, hR72, hR215) belonging to potential epitopes rat human renin. The main criteria were as follows: (1) include one catalytic sites or flap sequence; (2) low/no-similarity when matched with host proteome; (3) ideal antigenicity...
Abstract Although antiepileptic drugs (AEDs) are the most effective treatment for epilepsy, 30–40% of patients with epilepsy would develop drug-refractory epilepsy. An accurate, preliminary prediction efficacy AEDs has great clinical significance patient and prognosis. Some studies have developed statistical models machine-learning algorithms (MLAs) to predict progression disease after withdrawal, in order provide assistance making decisions aim precise, personalized treatment. The field...
Coronavirus disease 2019 (COVID-19), which is caused by a distinct coronavirus, an acute infectious that spreads mainly via the respiratory route. During COVID-19 outbreak, many healthcare systems faced severe burden when large number of workers (HCWs) became infected due to lack adequate protection. Consequently, it was apparent important ensure health and safety HCWs in order control outbreak throughout society. In this article, we share our successful protocol for protecting course their...