A5014713328- Spine and Intervertebral Disc Pathology
- Spinal Cord Injury Research
- Nerve injury and regeneration
- Musculoskeletal pain and rehabilitation
- Pluripotent Stem Cells Research
- Pregnancy-related medical research
- Natural Compounds in Disease Treatment
- Neuropeptides and Animal Physiology
- Neurogenesis and neuroplasticity mechanisms
- Mesenchymal stem cell research
- Tendon Structure and Treatment
- Extracellular vesicles in disease
- RNA Interference and Gene Delivery
- Fibroblast Growth Factor Research
- Corneal surgery and disorders
- Pharmacological Effects of Medicinal Plants
- Glaucoma and retinal disorders
- Bone and Joint Diseases
- Neurogenetic and Muscular Disorders Research
- Peptidase Inhibition and Analysis
- Calcium signaling and nucleotide metabolism
- Ocular Oncology and Treatments
- Cellular Mechanics and Interactions
- Tissue Engineering and Regenerative Medicine
- Circular RNAs in diseases
Wenzhou Medical University
2017-2024
Zhejiang University
2020-2024
Second Affiliated Hospital of Zhejiang University
2020-2024
Zhejiang Lab
2021-2024
Zhejiang University Medical College Affiliated Stomatological Hospital
2020-2022
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2017-2019
Abstract Therapeutics used to treat central nervous system (CNS) injury were designed repair neurites and inhibit cell apoptosis. Previous studies have shown that neuron-derived FGF10 exerts potential neuroprotective effects after cerebral ischemia injury. However, little is known about the role of endogenous in recovery process spinal cord (SCI). In this study, we found mainly produced by neuron microglia/macrophages, its expression increased SCI. Exogenous treatment improved functional...
The repair and motor functional recovery after spinal cord injury (SCI) remains a worldwide challenge. inflammatory microenvironment is one of main obstacles on inhibiting the SCI. Using mesenchymal stem cells (MSCs) derived extracellular vesicles to replace MSCs transplantation mimic cell paracrine secretions provides potential strategy for regulation. However, effective preservation controlled release in injured tissue are still not satisfied. Herein, we fabricated an injectable adhesive...
The current effective method for treatment of spinal cord injury (SCI) is to reconstruct the biological microenvironment by filling injured cavity area and increasing neuronal differentiation neural stem cells (NSCs) repair SCI. However, characterized several challenges including irregular wounds, mechanical electrical mismatch material-tissue interface. In study, a unique facile agarose/gelatin/polypyrrole (Aga/Gel/PPy, AGP3) hydrogel with similar conductivity modulus as was developed...
Abstract Treatments for osteoarthritis (OA) are designed to restore chondrocyte function and inhibit cell apoptosis. Previous studies have shown that activation of the glucagon-like peptide-1 receptor (GLP-1R) leads anti-inflammatory anti-apoptotic effects. However, role GLP-1R in pathological process OA is unclear. In present work, we aimed demonstrate potential effect on chondrocytes elucidate its underlying mechanisms. We found with liraglutide could protect against endoplasmic reticulum...
Abstract Rejuvenation of nucleus pulposus cells (NPCs) in degenerative discs can reverse intervertebral disc degeneration (IDD). Partial reprogramming is used to rejuvenate aging and ameliorate progression tissue avoiding formation tumors by classical reprogramming. Understanding the effects potential mechanisms partial provides insights for development new therapies IDD treatment. The findings present study show that through short‐term cyclic expression Oct‐3/4, Sox2, Klf4, c‐Myc (OSKM)...
Circular RNAs (circRNAs) play a critical regulatory role in degenerative diseases; however, their functions and therapeutic applications intervertebral disc degeneration (IVDD) have not been explored. Here, we identified that novel circATXN1 highly accumulates aging nucleus pulposus cells (NPCs) accountable for IVDD. CircATXN1 accelerates cellular senescence, disrupts extracellular matrix organization, inhibits mitochondrial respiration. Mechanistically, circATXN1, regulated by heterogeneous...
Spinal cord injuries impose a notably economic burden on society, mainly because of the severe after-effects they cause. Despite ongoing development various therapies for spinal injuries, their effectiveness remains unsatisfactory. However, deeper understanding metabolism has opened up new therapeutic opportunity in form metabolic reprogramming. In this review, we explore changes that occur during consequences, and tools available Normal is characterized by independent cellular intercellular...
Therapeutics used to treat central nervous system (CNS) injury are designed promote axonal regeneration and inhibit cell death. Previous studies have shown that liraglutide exerts potent neuroprotective effects after brain injury. However, little is known if treatment has spinal cord (SCI). This study explores the of associated underlying mechanisms. Our results showed could improve recovery by decreasing apoptosis as well increasing microtubulin acetylation, autophagy. Autophagy inhibition...
Abstract Introduction Astrogliosis and glial scar formation following spinal cord injury (SCI) are viewed as major obstacles that hinder axonal regeneration functional recovery. Regulating the in lesion site is important for treating SCI. Aims Considering role of astrocyte subsequent regeneration, we intended to investigate effect transcription factors OCT4 KLF4 on underlying mechanism after contusion transgenic mice. Results Western blotting, q‐PCR, immunofluorescence, evaluation suggested...
Mechanical stimulation is an effective approach for controlling stem cell differentiation in tissue engineering. However, its realization vivo repair remains challenging since this type of can hardly be applied to injectable seeding systems. Here, it presented that swelling microgels transformed situ mechanical via stretching the cells adhered on their surface. Poly(acrylamide-co-acrylic acid) with upper critical solution temperature property are fabricated using inverse emulsion...
Basic medical studies have reported an improved effect of osteocalcin on cognition. We explored the causal link between and dementia via implementation Mendelian randomization methodology.Genome-wide association were employed to identify single nucleotide polymorphisms (SNPs) showing significant correlations with osteocalcin. Subsequently, A two-sample analysis was conducted utilizing inverse-variance-weighted (IVW) technique assess relationship various types dementia, including Alzheimer's...
Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. However, challenges early diagnosis, high risk of liver metastasis, and lack effective targeted therapy lead to poor prognosis mortality UM. Therefore, generating an molecular tool for UM diagnosis treatment great significance. In this study, a UM-specific DNA aptamer, PZ-1, was successfully developed, which could specifically distinguish differences between cells noncancerous with nanomolar-range affinity...
Spinal cord injury (SCI) causes blood-spinal barrier (BSCB) disruption, leading to secondary damage, such as hemorrhagic infiltration, inflammatory response, and neuronal cell death. It is of great significance rebuild the BSCB at early stage SCI alleviate for better prognosis. Yet, current research involved in reconstruction insufficient. Accordingly, we provide a thermosensitive hydrogel-based G protein-coupled receptor 124 (GPR124) delivery strategy rebuilding BSCB. Herein, firstly found...
BACKGROUND:Osteoporosis is an increasingly prevalent disease characterized by decreased bone mass and deterioration of the microstructure, which contribute to increased fragility subsequent fractures, especially in elderly individuals. Rhizoma Drynariae (DRE) among most frequently used herbal medicines for treatment osteoporosis. Transdermal delivery a proven novel pathway drug has several advantages over traditional routes. MATERIAL AND METHODS:Female Sprague-Dawley osteoporotic fracture...
The extensive degeneration of functional somatic cells and the depletion endogenous stem/progenitor populations present significant challenges to tissue regeneration in degenerative diseases. Currently, a cellular reprogramming approach enabling directly generating corresponding progenitor from remains elusive. study focused on intervertebral disc (IVDD) identified three-factor combination (OCT4, FOXA2, TBXT (OFT)) that could induce dedifferentiation-like nucleus pulposus (dNPCs) toward...