A5101434075- Spine and Intervertebral Disc Pathology
- Catalytic C–H Functionalization Methods
- Radical Photochemical Reactions
- Spinal Cord Injury Research
- Musculoskeletal pain and rehabilitation
- Tendon Structure and Treatment
- Sulfur-Based Synthesis Techniques
- Nerve injury and regeneration
- Advanced Memory and Neural Computing
- Oxidative Organic Chemistry Reactions
- Tuberculosis Research and Epidemiology
- Kruppel-like factors research
- Corneal surgery and disorders
- Cancer Genomics and Diagnostics
- Animal Genetics and Reproduction
- Porphyrin and Phthalocyanine Chemistry
- Neural Networks and Reservoir Computing
- Extracellular vesicles in disease
- Mitochondrial Function and Pathology
- Mycobacterium research and diagnosis
- Bone and Joint Diseases
- Air Quality Monitoring and Forecasting
- Viral Infectious Diseases and Gene Expression in Insects
- Pluripotent Stem Cells Research
- Diagnosis and treatment of tuberculosis
Hebei University
2017-2025
Lanzhou University
2012-2024
Chengdu University of Traditional Chinese Medicine
2023
Second Affiliated Hospital of Zhejiang University
2020-2022
Zhejiang Lab
2021-2022
Zhejiang University
2020-2022
Zhejiang University Medical College Affiliated Stomatological Hospital
2020-2022
Lanzhou City University
2018
Environmental Protection Research Institute of Light Industry
1999
Shaanxi University of Science and Technology
1999
The current effective method for treatment of spinal cord injury (SCI) is to reconstruct the biological microenvironment by filling injured cavity area and increasing neuronal differentiation neural stem cells (NSCs) repair SCI. However, characterized several challenges including irregular wounds, mechanical electrical mismatch material-tissue interface. In study, a unique facile agarose/gelatin/polypyrrole (Aga/Gel/PPy, AGP3) hydrogel with similar conductivity modulus as was developed...
Thiosulfonylation and selenosulfonylation of vinyl azides with thiosulfonates selenosulfonates were achieved using Cu(dap)2Cl as a photosensitizer under visible-light irradiation. This reaction is the application azide substrate in group transfer radical addition (GTRA) reaction, through β-difunctionalization, to obtain variety unsymmetric difunctionalized N-unprotected enamines.
Abstract A free radical‐initiated methylation and/or α‐chloro‐β‐methylation of N ‐arylacrylamides with dimethyl sulfoxide under the analogous Fenton reaction condition has been developed, which provides an effective and facile cascade strategy for synthesis oxindoles chlorinated amides. magnified image
Abstract Rejuvenation of nucleus pulposus cells (NPCs) in degenerative discs can reverse intervertebral disc degeneration (IDD). Partial reprogramming is used to rejuvenate aging and ameliorate progression tissue avoiding formation tumors by classical reprogramming. Understanding the effects potential mechanisms partial provides insights for development new therapies IDD treatment. The findings present study show that through short‐term cyclic expression Oct‐3/4, Sox2, Klf4, c‐Myc (OSKM)...
Stem cell-based transplantation is a promising therapeutic approach for intervertebral disc degeneration (IDD). Current limitations of stem cells include with their insufficient cell source, poor proliferation capacity, low nucleus pulposus (NP)-specific differentiation potential, and inability to avoid pyroptosis caused by the acidic IDD microenvironment after transplantation. To address these challenges, embryo-derived long-term expandable progenitor (NPPCs) esterase-responsive ibuprofen...
Abstract Biomimetic tactile nervous system (BTNS) inspired by organisms has motivated extensive attention in wearable fields due to its biological similarity, low power consumption, and perception‐memory integration. Though many works about planar‐shape BTNS are developed, few researches could be found the field of fibrous (FBTNS) which is superior terms strong flexibility, weavability, high‐density Herein, a FBTNS with multimodal sensibility memory proposed, fusing poly lactic acid...
Neuromorphic computing holds immense promise for developing highly efficient computational approaches. Memristor-based artificial neurons, known due to their straightforward structure, high energy efficiency, and superior scalability, which enable them successfully mimic biological neurons with electrical devices. However, the reliability of memristors has always been a major obstacle in neuromorphic computing. Here, we propose an ultra-robust neuron negative differential resistance (NDR)...
Two C(sp3) radicals cross-coupling as a straightforward method for constructing C(sp3)–C(sp3) bonds has attracted extensive attention from chemists. Unfortunately, the strategy is challenging due to unexpected reactions of transient radicals, such homocoupling and hydrogen atom transfer. In this regard, capturing open-shell by metal catalysts can effectively enhance selectivity radical via formation more stable organometallic intermediates. Herein, we disclose selective two through dual...
Spinal cord injuries impose a notably economic burden on society, mainly because of the severe after-effects they cause. Despite ongoing development various therapies for spinal injuries, their effectiveness remains unsatisfactory. However, deeper understanding metabolism has opened up new therapeutic opportunity in form metabolic reprogramming. In this review, we explore changes that occur during consequences, and tools available Normal is characterized by independent cellular intercellular...
The first visible-light enabled metal-free aerobic protocol for one-pot synthesis of benzoin bis-ethers from alkenes and alcohols has been developed at room temperature.
Mechanical stimulation is an effective approach for controlling stem cell differentiation in tissue engineering. However, its realization vivo repair remains challenging since this type of can hardly be applied to injectable seeding systems. Here, it presented that swelling microgels transformed situ mechanical via stretching the cells adhered on their surface. Poly(acrylamide-co-acrylic acid) with upper critical solution temperature property are fabricated using inverse emulsion...
Abstract Introduction Astrogliosis and glial scar formation following spinal cord injury (SCI) are viewed as major obstacles that hinder axonal regeneration functional recovery. Regulating the in lesion site is important for treating SCI. Aims Considering role of astrocyte subsequent regeneration, we intended to investigate effect transcription factors OCT4 KLF4 on underlying mechanism after contusion transgenic mice. Results Western blotting, q‐PCR, immunofluorescence, evaluation suggested...
An environmentally friendly and highly diastereoselective method for synthesizing indanes has been developed via a metastable-state photoacid system containing catalytic protonated merocyanine (MEH). Under visible-light irradiation, MEH yields metastable spiro structure liberated protons, which facilitates the formation of carbocations from benzyl alcohols, thus delivering diverse molecules in presence various nucleophiles. Mainly, variety could be easily obtained alcohols olefins, water is...
Cellular niches play fundamental roles in regulating cellular behaviors. However, the effect of on direct converted cells remains unexplored. In present study, specific combination transcription factors is first identified to directly acquire induced nucleus pulposus-like (iNPLCs). Next, tunable physical properties collagen are fabricated based various crosslinking degrees. Collagen significantly affect actomyosin cytoskeleton and then influence maturation iNPLCs. Using gain- loss function...