A5100706505- Parasites and Host Interactions
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Immunology Research
- vaccines and immunoinformatics approaches
- Animal Virus Infections Studies
- Zoonotic diseases and public health
- Parasite Biology and Host Interactions
- Helminth infection and control
- Hepatitis C virus research
- interferon and immune responses
- Genomics and Phylogenetic Studies
- Respiratory viral infections research
- Virus-based gene therapy research
- NF-κB Signaling Pathways
- Immunotherapy and Immune Responses
- Cytomegalovirus and herpesvirus research
- Microtubule and mitosis dynamics
- Influenza Virus Research Studies
- RNA regulation and disease
- Viral Infections and Vectors
- Tracheal and airway disorders
- T-cell and B-cell Immunology
- Viral Infectious Diseases and Gene Expression in Insects
- Mosquito-borne diseases and control
Chongqing Medical University
2024
Children's Hospital of Chongqing Medical University
2024
Hangzhou Normal University
2024
National Institute for Parasitic Diseases
2024
Yunnan Institute of Endemic Diseases Control and Prevention
2013-2024
J. Craig Venter Institute
2012-2024
Yunnan Center for Disease Control And Prevention
2024
Westlake University
2024
Kunming Medical University
2023
University of California, San Diego
2022
The Virus Pathogen Database and Analysis Resource (ViPR, www.ViPRbrc.org) is an integrated repository of data analysis tools for multiple virus families, supported by the National Institute Allergy Infectious Diseases (NIAID) Bioinformatics Centers (BRC) program. ViPR contains information human pathogenic viruses belonging to Arenaviridae, Bunyaviridae, Caliciviridae, Coronaviridae, Flaviviridae, Filoviridae, Hepeviridae, Herpesviridae, Paramyxoviridae, Picornaviridae, Poxviridae,...
The Influenza Research Database (IRD) is a U.S. National Institute of Allergy and Infectious Diseases (NIAID)-sponsored Bioinformatics Resource Center dedicated to providing bioinformatics support for influenza virus research. IRD facilitates the research development vaccines, diagnostics therapeutics against by comprehensive collection influenza-related data integrated from various sources, growing suite analysis visualization tools mining hypothesis generation, personal workbench spaces...
Please cite this paper as: Squires et al. (2012) Influenza research database: an integrated bioinformatics resource for influenza and surveillance. Other Respiratory Viruses 6(6), 404–416. Background The recent emergence of the 2009 pandemic A/H1N1 virus has highlighted value free open access to genome sequence data with information about other important characteristics. Design Research Database (IRD, http://www.fludb.org ) is a free, open, publicly‐accessible funded by U.S. National...
SUMMARY The emergence of SARS-CoV-2 variants highlighted the need to better understand adaptive immune responses this virus. It is important address whether also CD4+ and CD8+ T cell are affected, because role they play in disease resolution modulation COVID-19 severity. Here we performed a comprehensive analysis SARS-CoV-2-specific from convalescent subjects recognizing ancestral strain, compared variant lineages B.1.1.7, B.1.351, P.1, CAL.20C as well recipients Moderna (mRNA-1273) or...
Several viruses within the Coronaviridae family have been categorized as either emerging or re-emerging human pathogens, with Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) being most well known. The NIAID-sponsored Virus Pathogen Database and Analysis Resource (ViPR, www.viprbrc.org) supports bioinformatics workflows for a broad range of virus pathogens other related viruses, including entire family. ViPR provides access to sequence records, gene protein annotations, immune...
Enterovirus D68 (EV-D68) has historically been associated with respiratory illnesses. However, in the summers of 2014 and 2016, EV-D68 outbreaks coincided a spike polio-like acute flaccid myelitis/paralysis (AFM/AFP) cases. This raised concerns that could be causative agent AFM during these recent outbreaks. To assess potential neurotropism EV-D68, we utilized neuroblastoma-derived neuronal cell line SH-SY5Y as culture model to determine if differential infection is observed for different...
The coronavirus (CoV) family includes several viruses infecting humans, highlighting the importance of exploring pan-CoV vaccine strategies to provide broad adaptive immune protection. We analyze T cell reactivity against representative Alpha (NL63) and Beta (OC43) common cold CoVs (CCCs) in pre-pandemic samples. S, N, M, nsp3 antigens are immunodominant, as shown for severe acute respiratory syndrome 2 (SARS2), while nsp2 nsp12 or specific. further identify 78 OC43- 87 NL63-specific...
Objective— The purpose of this study was to test the hypothesis that ACE2 overexpression may enhance atherosclerotic plaque stability by antagonizing ACE activity and converting angiotensin II 1–7. Methods Results— Atherosclerotic plaques were induced in abdominal aorta 114 rabbits endothelial injury atherogenic diet. Gene therapy performed group A at week 4 B 12, respectively. Each randomly divided into 3 subgroups which received, respectively, a recombinant expressing vector (AdACE2),...
Enterovirus D68 (EV-D68) caused a severe respiratory illness outbreak in the United States 2014. Reports of acute flaccid myelitis (AFM)/paralysis (AFP) several independent epidemiological clusters children with detectable EV-D68 have raised concerns that genetic changes could be causing increased disease severity and neurological symptoms. To explore potential link between variations symptom changes, we performed series comparative genomic analyses 2014 isolate sequences using data...
Oncomelania hupensis is the sole intermediate host of Schistosoma japonicum. Its emergence and recurrence pose a constant challenge to elimination schistosomiasis in China. It important accurately predict snail distribution for prevention control.Data describing O. 2016 was obtained from Yunnan Institute Endemic Disease Control Prevention. Eight machine learning algorithms, including eXtreme Gradient Boosting (XGB), support vector (SVM), random forest (RF), generalized boosting model (GBM),...
Rearranged during transfection (RET) rearrangement oncoprotein-mediated Ras/MAPK signaling cascade is constitutively activated in cancers. Here, we demonstrate a unique signal niche. The niche ternary complex based on the chimeric RET liquid–liquid phase separation. comprises rearranged kinase (RET fusion); adaptor (GRB2), and effector (SHC1). Together, they orchestrate cascade, which dependent tyrosine kinase. CCDC6-RET fusion undergoes LLPS requiring its domain partner. promotes...
High throughput sequencing has accelerated the determination of genome sequences for thousands human infectious disease pathogens and dozens their vectors. The scale scope these data are enabling genotype-phenotype association studies to identify genetic determinants pathogen virulence drug/insecticide resistance, phylogenetic track origin spread outbreaks. To maximize utility genomic purposes, it is essential that metadata about pathogen/vector isolate characteristics be collected made...
Scrub typhus, caused by Orientia tsutsugamushi, has emerged recently in Jingjiang City, China where the disease had not been known to exist. We analyzed epidemiological data, clinical characteristics and risk factors of scrub typhus outbreak 2013. The 271 clinically diagnosed patients were predominantly farmers 50 69 years old peak onset was early mid-November. For 187 laboratory-confirmed cases, major manifestations fever (100%), eschar (88.2%), rash (87.7%), chills headache (66.8%). A...
The aim of this study was to determine whether the indicators obtained from intravoxel incoherent motion (IVIM) imaging can improve characterization benign and malignant breast masses compared with conventional dynamic contrast-enhanced magnetic resonance (DCE-MRI) diffusion-weighted (DW-MRI).This included 23 31 48 patients. Main were initial enhancement ratio (IER), time-signal intensity curve (TIC), apparent diffusion coefficient (ADC), tissue diffusivity (D), pseudodiffusivity (D*),...
A complementary copper-catalyzed and electrochemical aminosulfonylation of O-homoallyl benzimidates N-alkenyl amidines with sodium sulfinates was developed. The terminal alkene substrate produced sulfone-containing 1,3-oxazines tetrahydropyrimidines in the presence Cu(OAc)2, Ag2CO3, DPP, under similar reaction conditions, sulfonylated tetrahydro-1,3-oxazepines were prepared from 1-aryl-substituted moderate to good yields. For certain electron-rich 1,1-diaryl-substituted substrates,...
Previous studies of the interaction between a functional polymorphism in serotonin transporter gene-linked promoter region (5-HTTLPR) and stress anxiety-related phenotypes have produced inconsistent results. The aim current study was to examine effect 5-HTTLPR × on anxiety symptoms Chinese adolescents. A total 651 healthy adolescents [323 females 328 males; age 14–17 (mean = 16.27, standard deviation 0.77)] participated this study. At initial assessment, participants completed self-report...
Abstract Background The elimination of schistosomiasis remains a challenging task, with current measures primarily focused on the monitoring and control Oncomelania hupensis (O. hupensis) snail, sole intermediate host Schistosome japonicum. Given emerging, re-emerging, persistent habitats snails, understanding their genetic diversity might be essential for successful control. aims this study were to analyze robertsoni h. robertsoni) using microsatellite DNA markers; validate applicability...