A5069093962- Ubiquitin and proteasome pathways
- Biochemical and Molecular Research
- Endoplasmic Reticulum Stress and Disease
- Peptidase Inhibition and Analysis
- Mosquito-borne diseases and control
- Bacteriophages and microbial interactions
- Influenza Virus Research Studies
- Virology and Viral Diseases
- HIV Research and Treatment
- vaccines and immunoinformatics approaches
- Glycosylation and Glycoproteins Research
- Genomics and Phylogenetic Studies
- Genetics and Neurodevelopmental Disorders
- ATP Synthase and ATPases Research
- Hepatitis C virus research
- Biomedical Ethics and Regulation
- RNA and protein synthesis mechanisms
- Iron Metabolism and Disorders
- Cytomegalovirus and herpesvirus research
- Trace Elements in Health
- SARS-CoV-2 and COVID-19 Research
- Folate and B Vitamins Research
- Cancer, Hypoxia, and Metabolism
- Respiratory viral infections research
- Machine Learning in Bioinformatics
Vecna Technologies (United States)
2012-2020
Northrop Grumman (United States)
2007
Los Alamos National Laboratory
2007
Cognia (United States)
2002
Cognizant (United States)
2002
Emory University
1992-1999
Harvard University
1997-1999
Ubiquitin C-terminal hydrolases (UCH) are deubiquitinating enzymes which hydrolyze esters and amides of ubiquitin. Here we report the processing a number ubiquitin derivatives by two human UCH isozymes (isozymes L1 L3) find that these show little discrimination based on P1' amino acid, except proline is cleaved slowly. Ubiquitinyllysine linked α- or ε-amino group hydrolyzed at identical rates. Isozyme-specific hydrolytic preferences only evident when leaving large. The gene products can be...
The Influenza Research Database (IRD) is a U.S. National Institute of Allergy and Infectious Diseases (NIAID)-sponsored Bioinformatics Resource Center dedicated to providing bioinformatics support for influenza virus research. IRD facilitates the research development vaccines, diagnostics therapeutics against by comprehensive collection influenza-related data integrated from various sources, growing suite analysis visualization tools mining hypothesis generation, personal workbench spaces...
Please cite this paper as: Squires et al. (2012) Influenza research database: an integrated bioinformatics resource for influenza and surveillance. Other Respiratory Viruses 6(6), 404–416. Background The recent emergence of the 2009 pandemic A/H1N1 virus has highlighted value free open access to genome sequence data with information about other important characteristics. Design Research Database (IRD, http://www.fludb.org ) is a free, open, publicly‐accessible funded by U.S. National...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMetabolism of the polyubiquitin degradation signal: structure, mechanism, and role isopeptidase TKeith D. Wilkinson, Valery L. Tashayev, Lydia B. O'Connor, Christopher N. Larsen, Eileen Kasperek, Cecile M. PickartCite this: Biochemistry 1995, 34, 44, 14535–14546Publication Date (Print):November 1, 1995Publication History Published online1 May 2002Published inissue 1 November...
Ubiquitin C-terminal hydrolases (UCH's) are a newly-defined class of thiol proteases implicated in the proteolytic processing polymeric ubiquitin. They important for generation monomeric ubiquitin, active component eukaryotic ubiquitin-dependent system. There at least three mammalian isozymes which tissue specific and developmentally regulated. To study structure functional roles these highly homologous enzymes, we have subcloned overexpressed two isozymes, UCH-L1 UCH-L3. Here, report their...
Several viruses within the Coronaviridae family have been categorized as either emerging or re-emerging human pathogens, with Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) being most well known. The NIAID-sponsored Virus Pathogen Database and Analysis Resource (ViPR, www.viprbrc.org) supports bioinformatics workflows for a broad range of virus pathogens other related viruses, including entire family. ViPR provides access to sequence records, gene protein annotations, immune...
Conference Article| August 01 1992 Comparisons of neuronal (PGP 9.5) and non-neuronal ubiquitin C-terminal hydrolases Keith D. Wilkinson; Wilkinson 1Department Biochemistry, Emory University School Medicine, Atlanta, GA 30322, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar Seema Deshpande; Deshpande Christopher N. Larsen Biochem Soc Trans (1992) 20 (3): 631–637. https://doi.org/10.1042/bst0200631 Article history Received: April 16 Views Icon contents Figures...
The BioHealthBase Bioinformatics Resource Center (BRC) ( http://www.biohealthbase.org ) is a public bioinformatics database and analysis resource for the study of specific biodefense health pathogens— Influenza virus, Francisella tularensis, Mycobacterium tuberculosis , Microsporidia species ricin toxin. serves as an extensive integrated repository data imported from databases, derived various computational algorithms information curated scientific literature. goal to facilitate development...
Enterovirus D68 (EV-D68) caused a severe respiratory illness outbreak in the United States 2014. Reports of acute flaccid myelitis (AFM)/paralysis (AFP) several independent epidemiological clusters children with detectable EV-D68 have raised concerns that genetic changes could be causing increased disease severity and neurological symptoms. To explore potential link between variations symptom changes, we performed series comparative genomic analyses 2014 isolate sequences using data...
The rapid spread of Zika virus (ZIKV) has caused much concern in the global health community, due part to a link fetal microcephaly and other neurological illnesses. While an increasing amount ZIKV genomic sequence data is being generated, understanding molecular biology still greatly lacking. A significant step towards establishing proteomics would be compilation all proteins produced by virus, resultant genotypes. Here we report for first time such data, using new computational methods...
The ubiquitin superfamily is a rich repository of small, conserved, functionally unique, and important proteins. Its member proteins fold simply similarly, with kinetic thermodynamic ease (Sorenson, J. M.; Head-Gordon, T. Toward minimalist models larger proteins: A ubiquitin-like protein. Proteins 2002, 46, 368-379). They have been implicated in numerous cancers, neurodegenerations, inflammations, various disorders affecting signal transduction or protein half-life. These serve the cell...
Sequence repositories have few well-annotated virus mature peptide sequences. Therefore post-translational proteolytic processing of polyproteins into peptides (MPs) has been performed in silico, with a new computational method, for over 200 species 5 pathogenic families (Caliciviridae, Coronaviridae, Flaviviridae, Picornaviridae and Togaviridae).Using pairwise alignment reference sequences, MPs annotated their sequences made available search, analysis download. At publication the method had...