A5040283651- Influenza Virus Research Studies
- Respiratory viral infections research
- Viral Infections and Vectors
- SARS-CoV-2 and COVID-19 Research
- COVID-19 epidemiological studies
- Viral gastroenteritis research and epidemiology
- Mosquito-borne diseases and control
- Viral Infections and Outbreaks Research
- Animal Virus Infections Studies
- Vector-Borne Animal Diseases
- interferon and immune responses
- Evolution and Genetic Dynamics
- Virus-based gene therapy research
- Vector-borne infectious diseases
- Chemical Analysis and Environmental Impact
- Analytical chemistry methods development
- Animal Disease Management and Epidemiology
- Plant Virus Research Studies
- Analytical Chemistry and Chromatography
- CRISPR and Genetic Engineering
- COVID-19 Clinical Research Studies
- Bacteriophages and microbial interactions
- RNA and protein synthesis mechanisms
- Pneumonia and Respiratory Infections
- Pediatric health and respiratory diseases
Jiangsu Provincial Center for Disease Control and Prevention
2014-2024
Xinjiang Uygur Autonomous Region Disease Prevention and Control Center
2024
Abstract A highly sensitive one‐step real‐time RT‐PCR method using a minor‐groove‐binding (MGB) probe was developed for detection and quantitation of severe febrile with thrombocytopenia syndrome virus (SFTSV). The assay could discriminate SFTSV infection from other related viral diseases in human minimum limit 10 RNA copies/µl 1,000 times more than the conventional PCR. Strong linear correlations (r 2 > 0.99) between C t values standards over range were obtained. coefficients variation...
Scrub typhus, caused by Orientia tsutsugamushi, has emerged recently in Jingjiang City, China where the disease had not been known to exist. We analyzed epidemiological data, clinical characteristics and risk factors of scrub typhus outbreak 2013. The 271 clinically diagnosed patients were predominantly farmers 50 69 years old peak onset was early mid-November. For 187 laboratory-confirmed cases, major manifestations fever (100%), eschar (88.2%), rash (87.7%), chills headache (66.8%). A...
Background: Human adenovirus (HAdV) is common pathogens that cause various respiratory diseases. The genetic diversity of viruses caused by recombination considered to be the main source emerging outbreaks. aim this study explore evolutionary relationship and events HAdV genome in tract infections Jiangsu Province. Methods: Whole-genome sequencing (WGS) technology was used sequence 66 patients with infection (37 influenza-like illness (ILI) 29 hospitalized pneumonia) from Epidemiological...
Background Four epidemic waves of human infection with H7N9 have been recorded in China up to 1 June 2016, including Jiangsu Province. However, few studies investigated the differences patients' characteristics among four waves, and analyses factors associated fatal lacked statistical power previous due limited sample size. Methods All laboratory‐confirmed A(H7N9) patients province were analysed. Patients' compared across between survivors those who died. Multivariate used identify...
Background: At present, the global sever acute respiratory syndrome coronavirus 2 (SARS-CoV-2) situation is still grim, and risk of local outbreaks caused by imported viruses high. Therefore, it necessary to monitor genomic variation genetic evolution characteristics SARS-CoV-2. The main purpose this study was detect entry different SARS-CoV-2 variants into Jiangsu Province, China. Methods: First, oropharyngeal swabs were collected from 165 patients (55 locally confirmed cases 110 with...
Avian influenza A(H5N6) keeps evolving, causing outbreaks in birds and sporadic infections human. Here, we report a fatal paediatric infection caused by novel reassortant H5N6 virus. The patient was an obese 9-year-old girl. She initiated with fever cough, then developed pneumonia, acute respiratory distress syndrome (ARDS) failure. Lower tract aspirates anal swabs were serially taken till the patient's death. Viral isolation, genome sequencing phylogenetic analysis conducted. A virus...
We investigated the seropositive rates and persistence of antibody against pandemic (H1N1) 2009 virus (pH1N1) in pregnant women voluntary blood donors after second wave Nanjing, China.Serum samples unvaccinated (n = 720) 320) were collected Nanjing. All tested pH1N1 strain (A/California/7/2009) with hemagglutination inhibition assay. A significant decline rates, from above 50% to about 20%, was observed fifteen weeks pandemic. quarter a seasonal H1N1 (A/Brisbane/59/2007). The titers found...
Background . Since 2020, global attention has heightened towards epidemics caused by avian influenza A H5N1 virus of clade 2.3.4.4b in birds and mammals. This study presents the epidemiological history, clinical manifestations, prognosis a unique case infected with 2.3.4.4b, along continuation SARS-CoV-2 viral RNAs, Eastern China. Methods We collected analysed patient’s clinical, epidemiological, virological data. Both sputum bronchoalveolar lavage fluid (BALF) samples were subjected to...
China implemented a dynamic zero-COVID strategy to curb viral transmission in response the coronavirus disease 2019 (COVID-19) pandemic. This was designed inhibit mutation of severe acute respiratory syndrome 2 (SARS-CoV-2), virus responsible for COVID-19. study explores dynamics evolution under stringent non-pharmaceutical interventions (NPIs) through real-world observations. Our analysis encompassed all polymerase chain reaction (PCR)-confirmed COVID-19 cases (n = 780) from two consecutive...
Severe fever with thrombocytopenia syndrome (SFTS) is an acute infectious disease caused by a novel phlebovirus (SFTSV), characterized fever, and leukocytopenia which lead to multiple organ failure high mortality in severe cases. The SFTSV has spread rapidly recent years posed serious threat public health endemic areas. However, specific antiviral therapeutics for infection are rare. In this study, we demonstrated that two peptides, SGc1 SGc8, derived from hydrophobic region of the...
Objective One H5N6 subtype avian influenza virus, A/environment/ Zhenjiang/C13/2013, was isolated from environment in Zhenjiang 2013 during epidemiological surveillance and identified by HA/HI test specific RT-PCR test. AIV subjected to genome sequencing investigate the genomic composition. Methods The next-generation (NGS) Illumina MiSeq Platform used obtain complete sequence information virus isolates. MEGA6.0 software align eight fragments of virus. The phylogenetic molecular...
Objective To analyze the genetic characteristics and evolution of influenza A (H3N2) virus strains circulating in Jiangsu province between 2013 2014. Methods This study analyzed thirty-one representative virus, which were isolated different regions during time periods from to 2014. Results Genetic distances nucleic acid amino a strain used for vaccine production (A/Texas/50/2012) 31 0.010 5 0.012 4. Similarities them sequences 97.9%-99.6% 97.2%-99.3%. Phylogenetic analysis...
Objective To analyze the molecular characteristics and genetic origin of a novel avian influenza A H7N4 virus casuing case human infection in China. Methods Specimens were collected from patient chickens ducks kept by neighbours then detected real-time quantitative PCR. The original specimens isolates analyzed next-generation sequencing technology to obtain viral whole-genome sequences. Pairwise sequence alignments phylogenetic analysis performed BLASTs, ClustalX MEGA 6.1...
Influenza-like illness (ILI) is an acute respiratory infection caused by various pathogens. However, the epidemiologic characteristics of ILI pathogens in Jiangsu province are unclear. To better understand etiology, from nasopharyngeal swab samples patients with collected 2012 to 2016 6 hospitals were studied. The pathogens, including influenza virus, syncytial virus (RSV), rhinovirus (HRV), adenovirus (ADV), herpes simplex (HSV), human coronavirus (hCoV), <i>Streptococcus pneumoniae</i> and...
Abstract Within the local outbreak period of SARS-CoV-2 Delta variant in Nanjing and Yangzhou, China, we analyzed mutation process variants 520 cases, as well production, spread elimination new mutant strains under non-pharmaceutical interventions (NPI) strategy. The investigation on distribution COVID-19 cases phylogenetic analysis genome sequences attributed to tracking transmission chains, chains were terminated by isolation patients quarantine close-contracts, suggesting importance NPI...