A5100732682- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipoproteins and Cardiovascular Health
- Cardiovascular Disease and Adiposity
- Nutritional Studies and Diet
- Bladder and Urothelial Cancer Treatments
- Ferroptosis and cancer prognosis
- Liver Disease Diagnosis and Treatment
- Renal and related cancers
- Renal cell carcinoma treatment
- Circular RNAs in diseases
- Inflammasome and immune disorders
- Cardiovascular Function and Risk Factors
- RNA modifications and cancer
- Health Systems, Economic Evaluations, Quality of Life
- Insect and Pesticide Research
- Acute Myocardial Infarction Research
- Urinary and Genital Oncology Studies
- Carbohydrate Chemistry and Synthesis
- Plant and animal studies
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer-related molecular mechanisms research
- Cardiac Imaging and Diagnostics
- Obesity, Physical Activity, Diet
- Educational Reforms and Innovations
- Radiomics and Machine Learning in Medical Imaging
First Affiliated Hospital of Zhengzhou University
2023-2025
China-US (Henan) Hormel Cancer Institute
2025
Zhengzhou University
2023-2025
Zhongda Hospital Southeast University
2021-2025
Zhejiang Chinese Medical University
2025
Eye & ENT Hospital of Fudan University
2024-2025
Jinan University
2024-2025
Second Affiliated Hospital of Guangzhou Medical University
2025
Guangzhou Medical University
2025
Xi'an University of Technology
2024
Cyclic GMP-AMP synthase (cGAS) is an enzyme in human cells that controls immune response to cytosolic DNA. Upon binding DNA, cGAS synthesizes a nucleotide signal 2′3′-cGAMP activates STING-dependent downstream immunity. Here, we discover cGAS-like receptors (cGLRs) constitute major family of pattern recognition innate Building on recent analysis Drosophila, identify >3,000 cGLRs present nearly all metazoan phyla. A forward biochemical screening 150 animal reveals conserved mechanism...
Our research was designed to investigate the relationship between systemic immune inflammation (SII) index and all-cause, cardiovascular disease (CVD), cancer-related mortality in patients with CVD. We used National Health Nutrition Examination Survey data from 1999 2018 conduct this study. The association SII CVD, CVD examined using restricted cubic splines (RCS), Cox proportional hazard models, subgroup analysis, respectively. defined as a composite of five outcomes including coronary...
Increased risk of stroke is highly associated with psychiatric disorders. We aimed to conduct the machine learning model based on multi-modal magnetic resonance imaging (MRI) radiomics predicting prognosis ischemic stroke.This study retrospectively analyzed 148 patients acute due anterior circulation artery occlusion. Based modified Rankin Scale (mRS) score, were divided into good (mRS ≤ 2) and poor > outcome groups. Segmentation infarct region was performed by manually outlining a mask...
Abstract Background and aims A novel non–insulin-based metabolic score for insulin resistance (METS‐IR) index has been proposed as a simple reliable alternative (IR) marker, but its the predictive value in asymptomatic adults with coronary artery calcification (CAC) remains unclear. Methods results We enrolled 1576 participants without cardiovascular disease (CVD), who underwent multidetector computed tomography. Logistic regression, restricted cubic spline models receiver operating...
Abstract Background There is evidence indicating that both lipoprotein(a) [Lp(a)] and fibrinogen (FIB) are associated with mortality, However, the impact of their combination on mortality has not been determined. Thus, aim this study was to examine association between Lp(a) FIB all-cause cause-specific mortality. Methods This prospective cohort enrolled 4,730 participants from third National Health Nutrition Examination Survey. The exposure variables included Lp(a), combination, while...
Clear cell renal carcinoma (ccRCC) presents challenges in early diagnosis and effective treatment. In this study, we aimed to establish a prognostic model based on G2M checkpoint-related genes identify associated clusters ccRCC through clinical bioinformatic analysis experimental validation. Utilizing single-cell RNA dataset (GSE159115) bulk-sequencing data from The Cancer Genome Atlas (TCGA) database, analyzed the checkpoint pathway ccRCC. Differential expression identified 45 with...
Chlorpyrifos (CPF) is a broad-spectrum organophosphate chloride (OP) insecticide widely used in domestic use and open field. However, there currently no relevant research revealing the toxic effects of CPF exposure on skin, then it necessary to comprehensively understand mechanisms. The results showed that skin tissue structure function mice were significantly disrupted after exposure. Furthermore, PPI network analysis molecular docking experiments pinpointed core targets such as Bcl2, EGFR,...
Abstract Background Alternative splicing (AS) is a process that facilitates the differential inclusion of exonic sequences from precursor messenger RNAs, significantly enhancing diversity transcriptome and proteome. In cancer, pathogenic AS events are closely related to cancer progression. This study aims investigate role regulatory mechanisms in gastric (GC). Methods We analyzed various tumor samples identified hnRNPU as key factor GC. The effects on progression were assessed through vitro...
Aims To assess the link between persistent lipoprotein(a) [Lp(a)] exposure levels and clinical outcomes in patients with acute myocardial infarction (AMI).
Bladder cancer (BLCA) exists a profound molecular diversity, with basal and luminal subtypes having different prognostic therapeutic outcomes. Traditional methods for subtyping are often time-consuming resource-intensive. This study aims to develop machine learning models using deep features from hematoxylin eosin (H&E)-stained whole-slide images (WSIs) predict in BLCA. RNA sequencing data clinical outcomes were downloaded seven public BLCA databases, including TCGA, GEO datasets, the...
The predictive value of triglyceride-glucose index (TyG) for cardiovascular disease (CVD) in the US elderly diabetic patients is ambiguous. This study aimed to investigate association between TyG and risk CVD an older population with diabetes. examined data from 2007-2016 National Health Nutrition Examination Survey (NHANES). Univariate multivariate regression analysis models were obtained explore baseline CVD. Non-linear investigated using restricted cubic spline (RCS) regression. Subgroup...
ABSTRACT Dysbiosis of intratumoral fungal and bacterial communities is associated with poor prognosis in various cancers. However, the mycobiome characteristics laryngeal squamous cell carcinoma (LSCC) its correlation recurrence have not yet been investigated. The 80 LSCC samples was characterized using internal transcribed spacer sequencing, encompassing both tumor tissues their matched para-cancerous tissues. bacteriome further identified 16S rRNA sequencing. These two microbial were...
This study aimed to investigate the relationship between lipoprotein(a) [Lp(a)] levels and non-alcoholic fatty liver disease (NAFLD), analyze its linear association subgroup differences. cross-sectional analysis was based on data from 2308 participants in National Health Nutrition Examination Survey (NHANES) III. Multivariate logistic regression models were used assess Lp(a) NAFLD, adjusting for demographic factors, lifestyle behaviors, comorbidities, biomarkers. Subgroup analyses conducted...
Growing studies have shown that insulin resistance (IR) is associated with cardiovascular disease (CVD), while the association between IR and subclinical myocardial injury (SC-MI) remains unclear. Hence we aimed to assess SC-MI.In this cross-sectional study, enrolled 6043 individuals (age: 58.43 ± 13.08 years; 46.2% men) free from CVD third National Health Nutrition Examination Survey. A novel metabolic score for (METS-IR) was used as alternative markers of IR. Multivariate logistic...
Background Growing studies have shown that insulin resistance (IR) is associated with poor prognoses among patients diabetes, whereas the association between IR and mortality has not been determined. Hence we aimed to evaluate associations all-cause, cardiovascular diseases (CVDs) cancer-related in diabetes. Methods We enrolled 2,542 participants diabetes an average age of 57.12 ± 0.39 years 52.8% men from 1999–2014 National Health Nutrition Examination Survey (NHANES 1999–2014). A novel...
Objective Although lipoprotein(a) [Lp(a)] and high-sensitivity C-reactive protein (Hs-CRP) are closely associated with the mortality of acute myocardial infarction (AMI), their synergistic effect on risk death remains unknown. Therefore, this study aimed to explore combined Lp(a) Hs-CRP incidence all-cause cardiovascular in AMI patients. Methods A comprehensive cohort enrolled 912 patients, categorizing them into four groups based levels: Group 1 [Lp(a) < 30 mg/dL & 2 mg/L], ≥...
Abstract Up to 30% of patients with metastatic castration‐resistant prostate cancer (CRPC) carry altered DNA damage response genes, enabling the use poly adenosine diphosphate–ribose polymerase (PARP) inhibitors in advanced CRPC. The proto‐oncogene mesenchymal–epithelial transition ( MET ) is crucial migration, proliferation, and invasion tumour cells. Aberrant expression its ligand hepatocyte growth factor associated drug resistance therapy. Here, we found that was highly expressed human...