A5102867637- Cancer-related Molecular Pathways
- Ubiquitin and proteasome pathways
- Cell death mechanisms and regulation
- CAR-T cell therapy research
- PI3K/AKT/mTOR signaling in cancer
- Chronic Lymphocytic Leukemia Research
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Lymphoma Diagnosis and Treatment
- Toxin Mechanisms and Immunotoxins
- DNA Repair Mechanisms
- NF-κB Signaling Pathways
- Microbial Natural Products and Biosynthesis
- Hops Chemistry and Applications
- Viral-associated cancers and disorders
- RNA modifications and cancer
- interferon and immune responses
- Immunotherapy and Immune Responses
- Cytomegalovirus and herpesvirus research
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Fungal Biology and Applications
- Autophagy in Disease and Therapy
- Health disparities and outcomes
- Plant-Microbe Interactions and Immunity
Central South University
2016-2025
Xiangya Hospital Central South University
2016-2025
Baylor College of Medicine
2016-2025
Nanyang Technological University
2022-2024
Jilin Agricultural University
2023
Third Xiangya Hospital
2020-2023
Baylor University
2022
Second Xiangya Hospital of Central South University
2017-2022
Hunan Cancer Hospital
2016-2021
Cleveland Clinic Lerner College of Medicine
2017-2020
Abstract Bacterial blight and bacterial leaf streak are serious, economically damaging, diseases of rice caused by the bacteria Xanthomonas oryzae pv. X. oryzicola . Bacillus amyloliquefaciens FZB42 was shown to possess biocontrol activity against these strains producing antibiotic compounds difficidin bacilysin. Analyses using fluorescence, scanning electron transmission microscopy revealed bacilysin changes in cell wall structure Biological control experiments on plants demonstrated...
Abstract Latent membrane protein 1 (LMP1) is a major Epstein–Barr virus (EBV)-encoded oncoprotein involved in latency infection that regulates mitochondrial functions to facilitate cell survival. Recently, fission has been demonstrated as crucial mechanism oncovirus-mediated carcinogenesis. Mitochondrial dynamin-related (Drp1)-mediated an impact on the chemoresistance of cancers. However, by which oncogenic stress promotes fission, potentially contributing tumorigenesis, not entirely...
BackgroundThe F-box protein S-phase kinase-associated 2 (Skp2) is overexpressed and correlated with poor prognosis in human malignancies, including colorectal cancer (CRC).MethodsA natural product library was used for compound screening through glycolysis analysis. The expression of Skp2 CRCs the inhibitory effect dioscin on were examined methods immunoblot, immunofluorescence, immunohistochemical staining, anchorage-dependent -independent growth assays, EdU incorporation assay,...
Programmed death-ligand 1 (PD-L1), a critical immune checkpoint ligand, is transmembrane protein synthesized in the endoplasmic reticulum of tumor cells and transported to plasma membrane interact with programmed death (PD-1) expressed on T cell surface. This interaction delivers coinhibitory signals cells, thereby suppressing their function allowing evasion antitumor immunity. Most companion or complementary diagnostic devices for assessing PD-L1 expression levels used clinic clinical...
Deregulation of glycolysis is a common phenomenon in human colorectal cancer (CRC).In the present study, we reported that Hexokinase 2 (HK2) overexpressed CRC tissues and cell lines, knockout HK2 inhibited proliferation, colony formation, xenograft tumor growth.We demonstrated natural compound, xanthohumol, has profound anti-tumor effect on via down-regulation glycolysis.Xanthohumol suppressed growth both vitro vivo.Treatment with xanthohumol promoted release cytochrome C activated intrinsic...
Abstract Necroptosis is an alternative programmed cell death pathway that unleashed in the absence of apoptosis and mediated by signaling complexes containing receptor-interating protein kinase 1 (RIPK1) RIPK3. This form has recently been implicated host defense system to eliminate pathogen-infected cells. However, only a few viral species such as herpes simplex virus (HSV) cytomegalovirus (CMV) have evolved mechanisms inhibiting necroptosis overcome antiviral defense, which important for...
Necroptosis/regulated necrosis is a caspase-independent, but receptor interacting protein kinase (RIPK)-dependent form of cell death. In previous studies, neoalbaconol (NA), constituent extracted from Albatrellus confluens, was demonstrated to induce necroptosis in some cancer lines. The molecular mechanism NA-induced described this research study. We determined that death partly dependent on tumor factor α (TNFα) feed-forward signaling. More importantly, NA abolished the ubiquitination...
Abstract Antibodies against programmed cell death protein 1 (PD-1) and its ligand (PD-L1) have dramatically changed the landscape of therapies for non-small lung carcinoma (NSCLC); however, majority patients do not respond to these agents. In addition, hyperprogressive disease (HPD) develops in a larger portion NSCLC treated with PD-1/PD-L1 inhibitors than standard chemotherapy. The use chimeric antigen receptor (CAR) T cells has been successful treat blood cancers but solid tumors like...
Activating mutations of epidermal growth factor receptor (EGFR) play crucial roles in the oncogenesis human non-small cell lung cancer (NSCLC). By screening 79 commercially available natural products, we found that compound deguelin exhibited a profound anti-tumor effect on NSCLC via directly down-regulating EGFR-signaling pathway. Deguelin potently inhibited vitro EGFR kinase activity wild type (WT), exon 19 deletion, and L858R/T790M-mutated EGFR. The silico docking study indicated was...
Overexpression of Skp2 plays a critical role in tumorigenesis and correlates with poor prognosis human malignancies. Thus, has been proposed as an attractive target for anti-tumor interventions. The expression colorectal cancer (CRC) the tumorigenic properties irradiation sensitivities CRC cells were examined by anchorage-dependent -independent growth assays, immunoblot, flow cytometry, immunohistochemical staining, ubiquitination analysis, co-immunoprecipitation assay, CRISPR-Cas9-based...
Many natural compounds derived from plants or microbes show promising potential for anticancer treatment, but few have been found to target energy-relevant regulators. In this study, we report that neoalbaconol (NA), a novel small-molecular compound isolated the fungus, Albatrellus confluens, could 3-phosphoinositide-dependent protein kinase 1 (PDK1) and inhibit its downstream phosphoinositide-3 (PI3-K)/Akt-hexokinase 2 (HK2) pathway, which eventually resulted in energy depletion. By...
Esophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies in China and an exceptionally drug-resistant tumor with a 5-year survival rate less than 15%. Cisplatin commonly used conventional chemotherapeutic drug for treatment ESCC, but some patients have poor response to cisplatin-based chemotherapy. New strategies that could enhance chemosensitivity cisplatin are needed. We reverse transcription-RCR (RT-PCR), immunoblot, immunohistochemical (IHC) staining,...
Abstract Epidermal growth factor receptor ( EGFR ) plays a crucial role in human non–small cell lung cancer NSCLC tumorigenesis. In this study, oxymatrine was identified as an signaling pathway inhibitor . Oxymatrine inhibited anchorage‐dependent and independent of lines but had no cytotoxicity normal cells. We found that exposure to not only suppressed the activity wild‐type also activation exon 19 deletion L858R/T790M mutated Flow cytometry analysis suggested oxymatrine‐induced cycle G0/G1...
Lymphoid neoplasms, including multiple myeloma (MM), non-Hodgkin lymphoma (NHL), and NK/T cell are a major cause of blood cancer morbidity mortality. CD38 (cyclic ADP ribose hydrolase) is transmembrane glycoprotein expressed on the surface plasma cells MM cells. The high expression across other lymphoid malignancies its restricted in normal tissues make an attractive target for immunotherapy. CD38-targeting antibodies, like daratumumab, have been approved treatment tested against leukemia...
Abstract Non-small cell lung cancer (NSCLC) is the most prevalent type of and leading cause cancer-related death. Chemotherapeutic resistance a major obstacle in treating NSCLC patients. Here, we discovered that E3 ligase Skp2 overexpressed, accompanied by downregulation necroptosis-related regulator MLKL human tissues lines. Knockdown inhibited viability, anchorage-independent growth, vivo tumor development cells. We also found protein negatively correlated with tissues. Moreover, increased...
Lipid nanoparticles (LNPs) for mRNA delivery have advanced significantly, but LNP-mediated DNA still faces clinical challenges. This study compared various LNP formulations delivering DNA-encoded biologics, assessing their expression efficacy and the protective immunity generated by LNP-encapsulated in different models. The formulation used Moderna's Spikevax vaccine (LNP-M) demonstrated a stable nanoparticle structure, high efficiency, low toxicity. Notably, encoding spike protein,...
Non-small cell lung cancer (NSCLC) is a common cause of cancer-related deaths worldwide, and its incidence has been increasing in recent years. While targeted therapies like osimertinib, an epidermal growth factor receptor tyrosine kinase inhibitor, have brought about notable improvements patient outcomes for advanced NSCLC, the challenge acquired drug resistance persists. Here, we found that cellular mesenchymal-epithelial transition (c-Met) was highly expressed osimertinib-resistant cells,...