A5075667586- MicroRNA in disease regulation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neonatal Respiratory Health Research
- Circular RNAs in diseases
- Connective Tissue Growth Factor Research
- Metabolomics and Mass Spectrometry Studies
- Asthma and respiratory diseases
- Extracellular vesicles in disease
- Pulmonary Hypertension Research and Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Medical Imaging and Pathology Studies
- Transplantation: Methods and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Esophageal Cancer Research and Treatment
- Cancer-related molecular mechanisms research
- Adipokines, Inflammation, and Metabolic Diseases
- Organ Transplantation Techniques and Outcomes
- Immune cells in cancer
- Ubiquitin and proteasome pathways
- Biomarkers in Disease Mechanisms
Second Xiangya Hospital of Central South University
2014-2024
Central South University
2014-2024
Northeast Agricultural University
2012
Objective To examine the correlation between SIRI and probability of cardiovascular mortality as well all-cause in individuals with chronic kidney disease. Methods A cohort 3,262 participants from US National Health Nutrition Examination Survey (NHANES) database were included study. We categorized into five groups based on stage weighted Cox regression model was applied to assess relationship mortality. Subgroup analyses, Kaplan–Meier survival curves, ROC curves conducted. Additionally,...
Abstract Background Esophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies with a 5-year survival rate less than 15%. Understanding molecular mechanisms involved in pathogenesis ESCC becomes critical to develop more effective treatments. Methods Mcl-1 expression was measured by reverse transcription (RT)-PCR and Western blotting. Human promoter activity evaluated reporter gene assay. The interactions between DNA factors were confirmed electrophoretic mobility shift...
Esophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies in China and an exceptionally drug-resistant tumor with a 5-year survival rate less than 15%. Cisplatin commonly used conventional chemotherapeutic drug for treatment ESCC, but some patients have poor response to cisplatin-based chemotherapy. New strategies that could enhance chemosensitivity cisplatin are needed. We reverse transcription-RCR (RT-PCR), immunoblot, immunohistochemical (IHC) staining,...
Abstract Deguelin, a natural rotenoid isolated from several plants, has been reported to exert anti‐tumour effects in various cancers. However, the molecular mechanism of this regulation remains be fully elucidated. Here, we found that deguelin inhibited growth non‐small cell lung cancer ( NSCLC ) cells both vitro and vivo by downregulation Bmi1 expression. Our data showed is highly expressed human tissues lines. Knockdown significantly suppressed proliferation colony formation. Deguelin...
IPF is an undetermined, progressive lung disease. Necroptosis a type of programmed apoptosis, which involved in the pathogenesis diseases like COPD and ARDS. However, necroptosis have not been adequately studied. This study aimed to investigate relationship between immune infiltration, construct prognostic prediction model based on necroptosis-related genes.GSE110147 was downloaded from GEO database utilized analyze expression differentially expressed genes (NRDEGs). Then NRDEGs were used...
Abstract Acute asthma exacerbation refers to the progressive deterioration of symptoms that is always triggered by virus infection represented respiratory syncytial (RSV). After RSV infection, exaggerated Th2‐mediated pulmonary inflammation critical pathological response asthmatic patients with acute exacerbation. Significantly, airway epithelial cells, being primary targets play a crucial role in controlling inflammatory releasing cell‐derived exosomes (AEC‐Exos), which potentially...
As a comprehensive analysis of all metabolites in biological system, metabolomics is being widely applied various clinical/health areas for disease prediction, diagnosis, and prognosis. However, challenges remain dealing with the metabolomic complexity, massive data, metabolite identification, intra- inter-individual variation, reproducibility, which largely limit its widespread implementation. This study provided workflow clinical metabolomics, including sample collection preparation, mass...
Renal interstitial fibrosis (RIF) is the main process that leads to renal failure. It necessary investigate mechanism of RIF and identify appropriate methods regulating it. Furthermore, unilateral ureteral obstruction a frequently used model for study RIF. The morphological damage associated with kidney lung dysfunction was detected using histopathological experiments. Subsequently, high expression reactive oxygen species (ROS) modulator 1 (ROMO1) ROS measured in blood serum. In addition,...
e15028 Background: Multi-cancer early detection (MCED) tests have emerged as promising tools for reducing cancer-related healthcare costs and mortality. As metabolome is closely linked to the phenotype of bio-individual, metabolomics analysis enables high throughput investigating pathophysiological conditions. Based on machine learning, we developed Multiple Cancer Target (MCTarg) multiple cancer screening diagnosis by a single blood draw. Methods: A total 1153 individuals (172 healthy...
Airway epithelial cells (AECs) regulate the activation of epithelial-mesenchymal trophic units (EMTUs) during airway remodelling through secretion signalling mediators. However, major trigger and intrinsic pathogenesis is still obscure.
Abstract Background Pulmonary fibrosis (PF) is a progressive and difficult-to-heal lung disease that poses significant threat to human life health. This study aimed investigate the potential pathological mechanisms of PF identify new avenues for treatment PF. Methods Clinical samples were collected assess effect disulfide-bond A oxidoreductase-like protein (DsbA-L) on TGF-β1-induced MLE-12 cell model bleomycin (BLM)-induced mice established. Changes in physiological morphology observed...
Cancer remains a leading cause of mortality worldwide. A non-invasive screening solution was required for early diagnosis cancer. Multi-cancer detection (MCED) tests have been considered to address the challenge by simultaneously identifying multiple types cancer within single test using minimally invasive blood samples. However, multi-cancer strategy utilizing urine-based metabolomics has not yet developed.
To further supplement the previous research on relationship between neutrophil-lymphocyte ratio (NLR) and all-cause cardiovascular mortality, construct clinical models to predict mortality.A total number of 2,827 observers were included from National Health Nutrition Examination Survey (NHANES) database in our research. NLR was calculated complete blood count. According quartile baseline NLR, those divided into four groups. A multivariate weighted Cox regression model used analyze...
To evaluate the effect of flavin-containing monooxygenase 3 (FMO3) genotype and dietary choline supplementation on trimethylamine (TMA) metabolism in HyLine Brown laying hens, a × 2 two-factorial arrangement was employed with FMO3 genotypes (AA, AT, TT) supplemental levels (370 2,960 mg/kg diet) as main effects. At 46 wk age, 108 hens AT TT were randomly allotted to one treatments, each treatment consisted 6 replicates 9 birds each. A total 24 AA treatments that hens. Hens fed diet 370 for 1...