A5100395546- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Genetic Associations and Epidemiology
- RNA modifications and cancer
- Nuclear Structure and Function
- Hepatitis C virus research
- Heat shock proteins research
- Immunotherapy and Immune Responses
- Microbial Inactivation Methods
- Gut microbiota and health
- RNA Interference and Gene Delivery
- Congenital limb and hand anomalies
- Nerve injury and regeneration
- Cardiomyopathy and Myosin Studies
- Genetics, Aging, and Longevity in Model Organisms
- Rheumatoid Arthritis Research and Therapies
- Cancer Mechanisms and Therapy
- Bone health and osteoporosis research
- Parvovirus B19 Infection Studies
- Neurogenetic and Muscular Disorders Research
- Hormonal and reproductive studies
- Animal Virus Infections Studies
- Genomics, phytochemicals, and oxidative stress
First Hospital of Jilin University
2010-2024
Jilin University
2010-2024
Central South University
2020-2024
Second Xiangya Hospital of Central South University
2020-2024
Shandong First Medical University
2023
Shandong Provincial Hospital
2023
Second Affiliated Hospital of Jilin University
2022
Third Xiangya Hospital
2021
Second Hospital of Shandong University
2020
Rational: Senescence is a major aging process that contributes to the development of cardiovascular diseases, but underlying molecular mechanisms remain largely unknown.One reason due lack suitable animal models.We aimed generate cardiomyocyte (CM)-specific senescent model, uncover mechanisms, and develop new therapies for associated cardiac dysfunction. Methods:The gain/loss circHIPK3 approach was used explore role in (CM) senescence.To investigate function senescence, we generated...
Alzheimer's disease (AD) is the most common neurodegenerative disease. In recent years, multiple pathway analyses of AD genome-wide association studies (GWAS) have been conducted, and provided strong support for immune pathways in AD. Rheumatoid arthritis (RA) a chronic autoimmune It reported that antirheumatic drugs had protective effect on dementia RA patients. However, observational controversial inverse relationship between RA. addition, Mendelian randomization also performed to evaluate...
Circular RNAs (circRNAs) which are shown as a class of exhibit the importance in regulation gene expression and development biological process. However, profile molecular mechanism circRNA ATXN7 (circATXN7) is still mostly uncertain gastric cancer (GC).qRT-PCR analysis was performed to detect circATXN7, miR-4319 ENTPD4 GC tissues cells. CCK-8, colony formation, EdU, flow cytometry, TUNEL transwell assays were conducted assess effect circATXN7 or on cell proliferation, apoptosis invasion. In...
Objectives The relationship between cathepsins and prostate cancer (PCa) has been reported. However, there is a lack of research on benign diseases (BPDs). This study investigated the potential genetic link BPDs through utilization Mendelian randomization (MR) analysis to determine if causal exists. Methods Publicly accessible summary statistics were obtained from FinnGen Biobank. data comprised 149,363 individuals, with 30,066 cases 119,297 controls for BPH, 123,057 3,760 prostatitis. IEU...
Circular RNAs (circRNAs) regulate gene expression by acting as a 'sponge' for microRNAs (miRs) and play crucial roles in tumorigenesis, including bladder cancer (BC). circRNA‑baculoviral IAP repeat‑containing 6 (circ‑BIRC6) has been reported to participate the pathogenesis of several types. The present study aimed elucidate potential mechanisms circ‑BIRC6 progression BC. levels BC cell lines were determined using reverse transcription‑quantitative PCR. Following knockdown, proliferation,...
Abstract Background Mink enteritis virus (MEV) causes a highly contagious viral disease of mink with worldwide distribution. MEV has linear, single-stranded, negative-sense DNA genome length approximately 5,000 bp. The VP2 protein is the major structural parvovirus encoded by vp 2 gene. antigenic and plays important roles in determining host ranges tissue tropisms. This study describes bionomics gene analysis mutated strain, MEV-DL, which was isolated recently China outlines its homologous...
DEK is known to be a potential proto‑oncogene and highly expressed in gastric cancer (GC); thus, considered contribute the malignant progression of GC. an RNA‑binding protein involved transcription, DNA repair, selection splicing sites during mRNA processing; however, its precise function remains elusive due lack clarification overall profiles gene transcription post‑transcriptional that are regulated by DEK. We performed our original whole‑genomic RNA‑Seq data analyze global alternative...
As an uncommon and congenital condition, macrodactyly is characterized by increase in the size of all elements or structures digits toes; however, underlying pathogenesis remains to be fully elucidated. In present study, gene expression profiles abnormal nerves were examined three patients with using microarray analysis identify potential genes contributing nerve overgrowth. Gene profiling tissue samples scanned differentially expressed verified at transcription level reverse...
Current therapeutic methods for melanoma have numerous limitations, and thus the improvement of such treatment are essential. One possible option is vaccination autologous inactivated tumor cells. The primary indispensable principles a cell-based vaccine include: i) Entire inactivation cells; ii) retaining immunogenicity iii) adherence to laws ethical guidelines. However, traditional production vaccine, as ultrasonic, chemotherapeutics freeze-thawing, some juridical or constraints....