Wenyu Han

ORCID: 0000-0003-0789-4214
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About
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Research Areas
  • Molecular Sensors and Ion Detection
  • Virus-based gene therapy research
  • Animal Virus Infections Studies
  • Chemical Synthesis and Reactions
  • X-ray Diffraction in Crystallography
  • Crystallization and Solubility Studies
  • Viral gastroenteritis research and epidemiology
  • Microbial Natural Products and Biosynthesis
  • Metal-Organic Frameworks: Synthesis and Applications
  • Fungal Biology and Applications
  • Virology and Viral Diseases
  • Inhalation and Respiratory Drug Delivery
  • Pediatric Pain Management Techniques
  • SARS-CoV-2 and COVID-19 Research
  • Toxoplasma gondii Research Studies
  • Acute Kidney Injury Research
  • Viral Infectious Diseases and Gene Expression in Insects
  • Plant Pathogens and Fungal Diseases
  • Anesthesia and Pain Management
  • Trauma, Hemostasis, Coagulopathy, Resuscitation
  • HIV Research and Treatment
  • Pain Management and Opioid Use
  • Bacterial biofilms and quorum sensing
  • Optical Systems and Laser Technology
  • Analytical Chemistry and Sensors

University of California, Los Angeles
1988-2023

Lanzhou Jiaotong University
2022-2023

China University of Geosciences
2023

Second Military Medical University
2017

Changhai Hospital
2017

Jilin University
2007-2016

South China Agricultural University
2007

Guangdong Provincial Center for Disease Control and Prevention
2007

Sun Yat-sen University
2007

Southern Medical University
2007

Several molecular forms of human neutrophil lipocalin/neutrophil gelatinase-associated lipocalin (HNL/NGAL), a novel biomarker for acute kidney injury (AKI), have been found in urine. The origin these different and the effect antibody configuration on assay performances were investigated this report.The HNL/NGAL from neutrophils present urine obtained cardiac surgery patients with urinary tract infection (UTI), as well secreted HK-2 cells, studied by Western blotting. levels measured ELISAs....

10.2215/cjn.00980110 article EN Clinical Journal of the American Society of Nephrology 2010-09-10

Natural products biosynthesized from biocontrol fungi in the rhizosphere can have both beneficial and deleterious effects on plants. Herein, we performed a comprehensive analysis of natural product biosynthetic gene clusters (BGCs) widely used fungus Trichoderma afroharzianum T22 (ThT22). This encodes at least 64 BGCs, yet only seven compounds four BGCs were previously characterized or mined. We correlated 21 ThT22 with known primary secondary metabolites through homologous BGC comparison...

10.1021/acs.jafc.3c03240 article EN Journal of Agricultural and Food Chemistry 2023-07-20

During the lactation cycle of bovine mammary gland, autophagy is induced in epithelial cells (BMECs) as a cellular homeostasis and survival mechanism. Interferon gamma (IFN-γ) an important antiproliferative apoptogenic factor that has been shown to induce multiple cell lines vitro. However, it remains unclear whether IFN-γ can affects milk synthesis BMECs. To understand synthesis, we isolated purified primary BMECs investigated effect on The results showed significantly inhibits was clearly...

10.14348/molcells.2016.2358 article EN cc-by-nc-sa Molecules and Cells 2016-03-30

Comparison of biosynthetic gene clusters (BGCs) found in devastating plant pathogens and biocontrol fungi revealed an uncharacterized conserved polyketide BGC. Genome mining identified the associated metabolite to be treconorin, which has a terpene-like, trans-fused 5,7-bicyclic core that is proposed derive from (4 + 3) cycloaddition. The esterified with d-glucose, derives glycosidic cleavage trehalose ester precursor. This glycomodification strategy different commonly observed glycosylation...

10.1021/jacs.3c10179 article EN cc-by Journal of the American Chemical Society 2023-11-10

Abstract Pseudomonas aeruginosa poses a major threat to human health and the mink industry. Thus, development of vaccines that elicit robust humoral cellular immunity against P. is greatly needed. In this study, recombinant attenuated Salmonella vaccine (RASV) expresses outer membrane proteins fusion OprF 190–342 ‐OprI 21–83 (F1I2) from was constructed potency candidate assessed by measuring F1I2‐specific immune responses upon vaccination through s.c. or oral routes. S.C. administration...

10.1111/1348-0421.12291 article EN Microbiology and Immunology 2015-08-07

The aim of this study was to assess the efficacy a fixed nitrous oxide/oxygen mixture for management breakthrough cancer pain.A double-blind, placebo-controlled, randomized clinical trial undertaken in Medical ward Tumor Hospital General Ningxia University. 240 patients with pain were recruited and randomly received standard treatment (morphine sulphate immediate release) plus pre-prepared mixture, or oxygen. primary endpoint measure numerical rating scale (NRS) score measured at baseline, 5...

10.1002/ejp.1144 article EN European Journal of Pain 2017-12-11

Abstract Background Mink enteritis virus (MEV) causes a highly contagious viral disease of mink with worldwide distribution. MEV has linear, single-stranded, negative-sense DNA genome length approximately 5,000 bp. The VP2 protein is the major structural parvovirus encoded by vp 2 gene. antigenic and plays important roles in determining host ranges tissue tropisms. This study describes bionomics gene analysis mutated strain, MEV-DL, which was isolated recently China outlines its homologous...

10.1186/1743-422x-7-124 article EN cc-by Virology Journal 2010-06-11

Although severe acute respiratory syndrome (SARS) has been controlled, the subsequently emerging sporadic cases in 2004 emphasize necessity of developing a rapid diagnostic method, which would be great help clinical diagnosis and also wild host screening. This study aims to establish an effective serological tool for SARS-CoV by comparison among whole viral, N N199 proteins ELISA.SARS-CoV (a truncated nucleocapsid gene) genes were cloned, expressed, identified Western blotting, applied...

10.1097/00029330-200712020-00007 article EN cc-by-nc-nd Chinese Medical Journal 2007-12-01

Catalysts played a vital role in fast dehydrogenation of Liquid Organic Hydrogen Carriers (LOHCs) for the large-scale application LOHCs technology. A series 1 wt% Pd/AlSiO catalysts with different Al/Si molar ratios were prepared by impregnation method to dehydrogenate perhydro-N-propylcarbazole as an important LOHC candidate. It is found that have dramatic influence on specific surface area, support acidity, metal reduction degree, and particle size. 100% can be realized 360 min catalyzed...

10.2139/ssrn.4330019 article EN 2023-01-01

A multifunctional fluorescent sensor Zn-MOF was successfully prepared by hydrothermal reaction, Zn2+ as node, 1,3,5-tris(1-imidazolyl)-benzene (L) and chiral ligands D(+)-camphoric acid (D-H2cam) linkers. It had been characterized single crystal X-ray diffraction (XRD), powder (PXRD), circular dichroism (CD), chromaticity coordinates (CIE) thermogravimetric analysis (TGA). The study of fluorescence properties revealed that the exhibited high selectivity sensitivity to detect HSO4− or...

10.2139/ssrn.4440747 preprint EN 2023-01-01

A multifunctional fluorescent sensor Zn-MOF was successfully prepared by hydrothermal reaction, Zn2+ as node, 1,3,5-tris(1-imidazolyl)-benzene (L) and chiral ligands D(+)-camphoric acid (D-H2cam) linkers. It had been characterized single crystal X-ray diffraction (XRD), powder (PXRD), circular dichroism (CD), chromaticity coordinates (CIE) thermogravimetric analysis (TGA). The study of fluorescence properties revealed that the exhibited high selectivity sensitivity to detect HSO4− or...

10.2139/ssrn.4281989 article EN SSRN Electronic Journal 2022-01-01
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