A5019288480- Ovarian cancer diagnosis and treatment
- Cancer-related molecular mechanisms research
- DNA Repair Mechanisms
- RNA modifications and cancer
- Endometriosis Research and Treatment
- Genetic factors in colorectal cancer
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- PARP inhibition in cancer therapy
- Wnt/β-catenin signaling in development and cancer
- Cancer-related Molecular Pathways
- Cancer Genomics and Diagnostics
- Reproductive System and Pregnancy
- Kruppel-like factors research
- Immune Cell Function and Interaction
- Atherosclerosis and Cardiovascular Diseases
- Lung Cancer Treatments and Mutations
- Genetic Associations and Epidemiology
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
- Cell death mechanisms and regulation
- Circular RNAs in diseases
- Angiogenesis and VEGF in Cancer
- Cancer Immunotherapy and Biomarkers
- Cancer, Lipids, and Metabolism
Fourth Hospital of Hebei Medical University
2014-2024
Hebei Medical University
2015-2024
Zhengzhou University
2023-2024
Capital Medical University
2020-2024
Yunnan Agricultural University
2024
Puer University
2024
Ningxia Medical University
2024
Beijing Chao-Yang Hospital
2024
Key Laboratory of Guangdong Province
2022
Sun Yat-sen Memorial Hospital
2022
Introduction: FENDRR is a long non-coding RNA (lncRNA) that mediates the modification of epigenetic landscape target promoters by binding to polycomb repressive complex 2. However, role in breast cancer remains unknown. Materials and methods: We detected expression 52 patients' tissues five cell lines. The association between clinicopathological features prognosis patients was also analyzed. Moreover, proliferation assays, flow cytometry analysis, wound-healing transwell migration assays...
Abstract Introduction The genetic risk effects of apolipoprotein E ( APOE ) on familial Alzheimer's disease (FAD) with or without gene mutations, sporadic AD (SAD), and normal controls (NC) remain unclear in the Chinese population. Methods In total, 15 119 subjects, including 311 FAD patients PSEN1, PSEN2, APP, TREM2 , SORL1 pathogenic mutations (FAD [unknown]); 126 PSENs / APP [ PSENs/APP ]); 7234 SAD patients; 7448 NC were enrolled. ε4 analyzed across groups. Results prevalence genotype...
Abstract Background: PCa is the most common cancer among men worldwide. Once patients have progressed to castration resistance, treatment options become scarce, leaving a substantial unmet need in mCRPC settings. Both B7-H3 and PSMA are tumor-associated antigens that exhibit high levels of expression PCa, dual targeting them with single agent represents promising therapeutic approach mCRPC. We developed GenSci143, novel B7-H3×PSMA-directed bispecific ADC comprised antibody against PSMA,...
Abstract Introduction: Cancer remains a leading cause of mortality worldwide. The multi-cancer early detection (MCED) test complements current screening methods improving and treatment outcomes. While most MCED tests focus on community populations, our MCTarg models were specifically designed to address both low-risk high-risk populations (e.g., those with conditions such as ulcerative colitis, adenomatous polyps, chronic bronchitis, tuberculosis, atrophic gastritis, H. pylori infection),...
Abstract Backgroud Accumulation of single nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) mitochondrial DNA (mtDNA) has been described for different types cancers and might be associated with cancer risk disease outcome. We used a population-based series esophageal squamous cell carcinoma (ESCC) patients investigating prediction power SNPs D-loop. Methods The D-loop region mtDNA was sequenced 60 ESCC recorded Fourth Hospital Hebei Medical University between 2003 2004. 5...
Abstract Purpose One major reason of the high mortality epithelial ovarian cancer (EOC) is due to platinum-based chemotherapy resistance. Aberrant DNA methylation may be a potential mechanism underlying development platinum resistance in EOC. The purpose this study discover aberrant that contributes drug Methods By initially screening 16 platinum-sensitive/resistant samples from EOC patients with reduced representation bisulfite sequencing (RRBS), upstream region hMSH2 gene was discovered...
Abstract Background Observational studies have revealed that type 2 diabetes (T2D) is associated with an increased risk of peripheral artery disease (PAD). However, whether the two diseases share a genetic basis and relationship causal remain unclear. It also unclear as to these relationships differ between ethnic groups. Methods By leveraging large-scale genome-wide association study (GWAS) summary statistics T2D (European-based: N case = 21,926, control 342,747; East Asian-based: 36,614,...
Unintended off-target mutations induced by CRISPR/Cas9 nucleases may result in unwanted consequences, which will impede the efficient applicability of this technology for genetic improvement. We have recently edited goat genome through targeting MSTN and FGF5, increased muscle fiber diameter hair length, respectively. Using family trio-based sequencing that allow better discrimination variant origins, we herein generated offspring from goats, sequenced members four trios (gene-edited goats...
X-ray repair cross complementing 1 (XRCC1) protein plays an important role in base excision repair. Single nucleotide polymorphisms (SNPs) XRCC1 gene may affect DNA repairing ability and genetic susceptibility to cancer. This study was designed investigate the correlation of Arg194Trp Arg280His Arg399Gln SNPs with risk gastric cardiac adenocarcinoma (GCA). Genotypes were analyzed by polymerase chain reaction-restriction fragment length polymorphism assay 455 patients GCA 650 age sex-matched...
Recent evidence suggests that Sort1 promotes carcinogenesis and tumor progression in multiple types of cancers. This study investigates the role hepatocellular carcinoma (HCC).The differentially expressed gene was screened through GEO TCGA databases. The identified its expression then verified by HCCDB (a database atlas) Human Protein Atlas used to assess tissues. KM-plotter databases were relationship between HCC. correlation immune cells evaluated TIMER database. GO KEGG enrichment...
Growing evidences indicate that single nucleotide polymorphisms (SNPs) of matrix metalloproteinases (MMPs) gene promoter may alter MMPs protein expression levels to influence malignant tumors developing and progressing. Our study was assess the effects SNPs in region MMP-12 MMP-13 on risk epithelial ovarian carcinoma (EOC) progressing.MMP-12 A-82G A-77G were genotyped by polymerase chain reaction-restriction fragment length polymorphism 256 EOC patients 329 controls.The A/G genotype...
The FAS and FASL system play an important role in regulating apoptotic cell death. This study was designed to investigate the correlation of FAS-1377 G/A, -670 A/G FASL-844 T/C polymorphisms with susceptibility gastric cardiac adenocarcinoma a population high-incidence region Hebei Province.FAS-1377 were genotyped by polymerase chain reaction-restriction fragment length polymorphism analysis 262 carcinoma (GCA) patients 524 healthy controls.Family history upper gastrointestinal cancer (UGIC)...
Objective: The nucleotide excision repair (NER) and base (BER) pathways, two DNA are related to platinum resistance in cancer treatment. In this paper, we studied the association between single polymorphisms (SNPs) of involved genes response platinum-based chemotherapy epithelial ovarian cancer. Method: Eight SNPs XRCC1 (BER), XPC XPD were assessed 213 patients with using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) primer-introduced restriction...
Is the methylation status of glutathione S-transferase M1 (GSTM1) promoter region altered in patients with ovarian endometriosis, and does this affect expression GSTM1 their endometrial tissues?The was significantly hypomethylated ectopic eutopic endometrium endometriosis associated higher mRNA.GSTM1, a member family, is primarily known as detoxification enzyme, but it has also been shown to negatively regulate apoptosis-related signalling cascades through protein-protein interactions...
The purpose of this experiment is to explore the role long intergenic noncoding RNA 261 (LINC00261) gene in chemoresistance and clinical prognosis epithelial ovarian cancer (EOC).