A5103283686- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Esophageal and GI Pathology
- Colorectal Cancer Screening and Detection
- Gastrointestinal disorders and treatments
- Colorectal Cancer Surgical Treatments
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Treatments and Studies
- Helicobacter pylori-related gastroenterology studies
- Inflammatory Bowel Disease
- Gastrointestinal Bleeding Diagnosis and Treatment
- Diverticular Disease and Complications
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Colorectal and Anal Carcinomas
- Metabolomics and Mass Spectrometry Studies
- Pancreatitis Pathology and Treatment
- Gallbladder and Bile Duct Disorders
- Circular RNAs in diseases
- Pharmacological Effects of Natural Compounds
- Esophageal Cancer Research and Treatment
- Biliary and Gastrointestinal Fistulas
- Inflammatory Biomarkers in Disease Prognosis
- Genetic factors in colorectal cancer
First Affiliated Hospital of Nanchang University
2014-2025
Nanchang University
2014-2025
First Affiliated Hospital of Jiangxi Medical College
2023-2025
Jiangxi Chest Hospital
2024
Creative Commons
2019
National Natural Science Foundation of China
2019
China University of Mining and Technology
2016
Importance The clinical effects of risankizumab (a monoclonal antibody that selectively targets the p19 subunit IL-23) for treatment ulcerative colitis are unknown. Objective To evaluate efficacy and safety when administered as an induction a maintenance therapy patients with colitis. Design, Setting, Participants Two phase 3 randomized trials were conducted. trial was conducted at 261 centers (in 41 countries) enrolled 977 from November 5, 2020, to August 4, 2022 (final follow-up on May 16,...
Introduction: Colon cancer is a frequent malignancy, and surgery still the primary therapy for people with colon cancer. Other treatments, including radiation, chemotherapy, biologic therapy, may be utilized as supplement. Chemotherapy, prominent treatment cancer, has failed to provide positive outcomes. This necessitates development of more effective less harmful drugs. Coptisine was discovered inhibit cell line HCT-116 in vivo, decrease growth cells, cause apoptosis vitro (COP) shown...
Backgrounds: Colorectal cancer (CRC) is a highly malignant gastrointestinal malignancy with poor prognosis, which imposes significant burden on patients and healthcare providers globally.Previous studies have established that genes related to glutamine metabolism play crucial role in the development of CRC.However, no yet explored prognostic significance these CRC.Methods: CRC patient data were downloaded from The Cancer Genome Atlas (TCGA), while metabolism-related obtained Molecular...
ABSTRACT Purpose/Backgrounds Colorectal polyps (CRPs) are precursors to colorectal cancer (CRC), and early detection is crucial for prevention. Traditional diagnostic methods invasive, prompting a need noninvasive biomarkers. This study aimed identify urinary metabolite biomarkers diagnosing CRPs construct nomogram based on screening. Patients Methods A total of 192 participants, including 64 CRP patients 128 healthy controls, were recruited. Urine samples analyzed using untargeted gas...
Numerous studies have confirmed that intestinal flora is closely linked to the development of gastrointestinal polyps. However, precise causal link between them has yet be clarified. This study sought determine relationship gut microbiota and gastric, duodenal, colon, rectal polyps by Mendelian randomization (MR). We employed publicly available genome-wide association summary data conduct MR analysis. Gut were sourced from International MiBioGen Consortium, polyp obtained MRC-IEU Consortium....
Abstract Introduction: Cancer remains a leading cause of mortality worldwide. The multi-cancer early detection (MCED) test complements current screening methods improving and treatment outcomes. While most MCED tests focus on community populations, our MCTarg models were specifically designed to address both low-risk high-risk populations (e.g., those with conditions such as ulcerative colitis, adenomatous polyps, chronic bronchitis, tuberculosis, atrophic gastritis, H. pylori infection),...
Previous studies have demonstrated that microRNA (miRNA) are essential in tumor development and invasion. The close association between focal adhesion kinase (FAK) colon cancer (CC) has been previously reported. miRNA‑7 (miR‑7) inhibits the translation of FAK protein. Therefore, present study aimed to assess underlying molecular mechanism miR‑7 human CC cell lines, provide a novel therapeutic biomarker future. detected expression 60 tissues by reverse transcription‑quantitative polymerase...
Abstract: Inflammatory bowel disease (IBD), which includes Crohn's and ulcerative colitis, is an intestinal with complicated pathological mechanisms. The incidence of IBD has been increasing in recent years, a significant negative impact on the lives patients. Therefore, it particularly important to find new therapeutic targets innovative drugs for development IBD. Recent studies have revealed that NLRP3 inflammatory vesicles can play role maintaining homeostasis sustaining immune response...
Esophageal foreign bodies are often treated by endoscopy, but the treatment of esophageal perforation caused remains controversial. The purpose this study was to investigate safety and efficacy nonoperative bodies.We retrospectively analyzed 270 patients admitted our hospital for from January 2012 December 2020, all whom received treatment.The mean age 56 ± 17 years, fish bones were most common type body. A total 61.2% perforations in cervical esophagus. All initially, body removal rate...
Chronic colorectal inflammation has been associated with cancer (CRC); however, its exact molecular mechanisms remain unclear. The present study aimed to investigate the effect of Toll-like receptor 9 (TLR9) on development colitis-associated CRC (CAC) through regulation NF-κB signaling pathway. By using a CAC mouse model and immunohistochemistry, discovered that protein expression levels TLR9 were gradually upregulated during CRC. In addition, revealed be positively correlated Ki67 levels....
Circular RNA (circRNA) was first observed in the cytoplasm of eukaryotic cells 1979, but it not characterized detail until 2012, when high‑throughput sequencing technology more advanced and available. Consequently, mechanism circRNA formation its biological function have been progressively elucidated by researchers. is abundant exhibits a certain degree organization, timing disease‑specificity. Additionally, poorly degradable, meeting characteristics an ideal clinical biomarker. In present...
The over-the-scope clip (OTSC) is an innovative device and has been successfully used in endoscopic treatment, however, there a lack of clinical data from China. aim this study to investigate the OTSC applications treatment upper non-variceal gastrointestinal bleeding (UNVGIB), perforations, fistulas In total, 80 patients were treated with one respectively as first-line therapy our endoscopy center between January 2016 November 2020. Among them, 41 had UNVGIB, 34 five fistulas. technical...
Colorectal cancer (CRC) has one of the highest incidences and mortality rates all malignancies worldwide. microRNAs (miRNAs) have been reported to be involved in many biological processes diseases. MiR-22-3p is considered progression, but its role CRC remains unclear. In this study, we detected that CRC, level miR-22-3p downregulated. antitumor effects CRC. can reduce proliferative, invasive migrative capacity cells. Luciferase reporter analyses confirmed KDM3A was a target miR-22-3p, which...
As a comprehensive analysis of all metabolites in biological system, metabolomics is being widely applied various clinical/health areas for disease prediction, diagnosis, and prognosis. However, challenges remain dealing with the metabolomic complexity, massive data, metabolite identification, intra- inter-individual variation, reproducibility, which largely limit its widespread implementation. This study provided workflow clinical metabolomics, including sample collection preparation, mass...
Objective Inflammatory bowel disease (IBD) and alcohol use has become a significant growing public health concern. Alcohol been reported to be the most-avoided diet item among IBD patients. However, knowledge regarding impact of different classes alcoholic beverages on management is limited. Our study aims evaluate association frequencies, amounts, subtypes with risk. Methods The UK Biobank comprised 7,095 subjects 4,95,410 without IBD. Multivariate Logistic regression, stratifying analysis,...
Abstract Background Colonoscopy is the standard and most effective screening tool for colonic diseases accuracy of colonoscopy depends on quality bowel preparation. The aim this study was to analyze risk factors inadequate preparation before colonoscopy. Methods In retrospective study, patients who underwent in 2018 received 3 L Polyethylene Glycol Electrolytes powder were included. They instructed drink 1.5 night 4–6 h procedure given doses 250 ml every 10 min with 30 simethicone Patient-...
Immune checkpoint inhibitors could restore immune surveillance to attack tumor through targeting CTLA-4, PD-1 or PD-L1, and have achieved huge success. However, immune-related adverse events (irAEs) been attracting attention as their application is expanding. Gastritis relatively rare a subtype of irAEs, particularly severe gastritis. Guidelines on its clinical management still remain undefined due limited data. Sintilimab inhibitor approved in China. Here we offer case sintilimab-induced...