A5101958641- T-cell and B-cell Immunology
- Alcohol Consumption and Health Effects
- Liver Disease Diagnosis and Treatment
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Eicosanoids and Hypertension Pharmacology
- Plasma Diagnostics and Applications
- Epilepsy research and treatment
- Systemic Lupus Erythematosus Research
- Urinary Bladder and Prostate Research
- Neuroscience and Neuropharmacology Research
- Drug Transport and Resistance Mechanisms
- Fatty Acid Research and Health
- Diabetes and associated disorders
- Plasma Applications and Diagnostics
- Electrohydrodynamics and Fluid Dynamics
- Immunodeficiency and Autoimmune Disorders
- Cardiomyopathy and Myosin Studies
- Phagocytosis and Immune Regulation
- Tryptophan and brain disorders
- Nanoplatforms for cancer theranostics
- Hematopoietic Stem Cell Transplantation
Army Medical University
2022-2025
Indiana University School of Medicine
2020-2024
Indiana University – Purdue University Indianapolis
2020-2024
Affiliated Hospital of Guizhou Medical University
2024
Guiyang Medical University
2024
Alpine Immune Sciences (United States)
2019-2023
Nanjing Tech University
2016-2022
First Affiliated Hospital of Nanchang University
2022
Nanchang University
2022
University of Science and Technology of China
2022
Methicillin-resistant Staphylococcus aureus (MRSA) causes osteomyelitis (OM), which seriously threatens public health due to its antimicrobial resistance. To increase the sensitivity of antibiotics and eradicate intracellular bacteria, a Zn2+ vancomycin (Van) codelivered nanotherapeutic (named Man-Zn2+/Van NPs) was fabricated characterized via mannose (Man) modification. NPs exhibit significant inhibitory activity against extra- MRSA obviously decrease minimum concentration Van. can be...
Objective Dysregulated APRIL/BAFF signaling is implicated in the pathogenesis of multiple autoimmune diseases, including systemic lupus erythematosus and nephritis. We undertook this study to develop evaluate a high‐affinity antagonist overcome clinical limitations existing B cell inhibitors. Methods A variant TACI‐Fc generated by directed evolution showed enhanced binding for both APRIL BAFF was designated povetacicept (ALPN‐303). Povetacicept compared wild‐type (WT) related molecules vitro...
Abstract NMDA receptors interact with a variety of intracellular proteins at excitatory synapses. In this paper we show that myosin regulatory light chain (RLC) isolated from mouse brain is receptor‐interacting protein. Myosin RLC bound directly to the C‐termini both receptor 1 (NR1) and 2 (NR2) subunits, rendering interaction distinct calmodulin which considered NR1‐interacting co‐localized NR1 in dendritic spines hippocampal neurons, was co‐immunoprecipitated extracts complex NR1, NR2A,...
Acute graft-versus-host disease (aGVHD) remains a major complication of allogeneic hematopoietic cell transplantation (HCT). CD146 and CCR5 are proteins that mark activated T helper 17 (Th17) cells. The Th17 phenotype is promoted by the interaction receptor ICOS on cells with ligand (ICOSL) dendritic (DCs). We performed multiparametric flow cytometry in cohort 156 HCT recipients conducted experiments aGVHD murine models to understand role ICOSL+ DCs. observed an increased frequency...
Alcoholic hepatitis (AH) is a severe inflammatory liver disease that develops in some heavy drinkers. The immune system patients with AH hyperactive and yet dysfunctional. Here, we investigated whether this immune‐dysregulated state related to the alcoholic impact on checkpoints (ICPs). We used multiplex immunoassays enzyme‐linked immunosorbent assay quantify plasma levels of 18 soluble ICPs (sICPs) from 81 AH, 65 drinkers without diseases (HDCs), 39 healthy controls (HCs) at baseline, 33 32...
Abstract ALPN‐101 (ICOSL vIgD‐Fc) is an Fc fusion protein of a human inducible T cell costimulatory ligand (ICOSL) variant immunoglobulin domain (vIgD) designed to inhibit the cluster differentiation 28 (CD28) and costimulator (ICOS) pathways simultaneously. A first‐in‐human study evaluated safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) in healthy adult subjects. was generally well‐tolerated with no evidence cytokine release, clinically significant immunogenicity, or...
Excitatory synapses contain multiple members of the myosin superfamily molecular motors for which functions have not been assigned. In this study we characterized determinants regulatory light chain (RLC) binding to two major subunits N-methyl-d-aspartate receptor (NR). Myosin RLC bound NR in a manner that could be distinguished from interaction with neck region non-muscle II-B (NMII-B) heavy chain; NR-RLC interactions did require addition magnesium, were maintained absence fourth EF-hand...
Objective Inflammatory bowel disease (IBD) and alcohol use has become a significant growing public health concern. Alcohol been reported to be the most-avoided diet item among IBD patients. However, knowledge regarding impact of different classes alcoholic beverages on management is limited. Our study aims evaluate association frequencies, amounts, subtypes with risk. Methods The UK Biobank comprised 7,095 subjects 4,95,410 without IBD. Multivariate Logistic regression, stratifying analysis,...
Heavy alcohol consumption disrupts gut epithelial integrity, leading to increased permeability of the gastrointestinal tract and subsequent translocation microbes. Regenerating islet-derived protein 3α (REG3α) Trefoil factor 3 (TFF3) are mainly secreted lumen by Paneth Goblet cells, respectively, functionally linked barrier integrity. Circulating levels REG3α TFF3 have been identified as biomarkers for damage in several human diseases. We examined whether plasma were dysregulated correlated...
Alcoholic hepatitis (AH) is a severe inflammatory liver disease that develops in some heavy drinkers. AH patients have intense hepatic infiltration of leukocytes. Up-regulation cell adhesion molecules (CAMs) upon endothelial (EC) activation plays an important role leukocyte transendothelial migration. CAMs can shed from EC surface and accumulate the blood, serving as soluble markers for activation. In this study, we examined impact drinking on expression forms (CD146, ICAM-1, VCAM-1, VEGF-A)...
The combination of levofloxacin and α1 adrenergic antagonist treatment is the current preferred choice for both bacterial non-bacterial prostatitis. aim this study to explore influence antagonists on pharmacokinetics using rat models with acute prostatitis (ABP) induced by direct injection Escherichia coli (ATCC25922). A total 96 model rats were randomly assigned into two groups: experimental group (treated tamsulosin levofloxacin, n=48) control solvents, n=48). Six from each euthanized...
Abstract In view of the fact that most existing building information modeling (BIM) platforms are based on Client/Server (C/S) mode client-side applications, which brings about problems such as weak data interoperability, poor model semantic integrity and bad user-friendliness, this paper proposed an IFC-JSON IFC-glTF file format conversion process WebGL improved Draco algorithm can further lighten glTF files. The experimental results showed option effectively reduce redundancy, then...
Abstract Background Chronic excessive alcohol consumption leads to a spectrum of alcohol-associated liver diseases (ALD), including alcoholic hepatitis (AH). AH is characterized by intense systemic and inflammation, posing significant risks health complications mortality. While inflammation crucial defense mechanism against injury infection, its timely resolution essential prevent tissue damage restore homeostasis. The an actively regulated process, primarily governed specialized...
Alcoholic hepatitis (AH) is characterized by intense systemic and liver inflammation, posing significant risks of health complications mortality. While inflammation a crucial defense mechanism against injury infection, its timely resolution essential to prevent tissue damage restore homeostasis. The primarily governed specialized pro-resolving mediators (SPMs), lipid metabolites derived from w-6 w-3 poly-unsaturated fatty acids (PUFAs). Currently, the balance between pro-inflammatory (PLMs)...
Background: BAFF and APRIL are TNF superfamily members that form homo- heteromultimers bind TACI BCMA on B cells; also binds BAFF-R. support cell development, differentiation, survival, particularly for plasmablasts plasma cells, play critical roles in the pathogenesis of cell-related autoimmune diseases. In nonclinical models, inhibition either or alone mediates relatively modest effects, whereas their co-neutralization dramatically reduces function, including antibody production. Fc...
BackgroundALPN-101 (ICOSL vIgD-Fc) is an Fc fusion protein of a human ICOSL variant immunoglobulin domain (vIgD™) designed to simultaneously inhibit the ICOS and CD28 costimulatory pathways. bind CD80/CD86, respectively, play critical roles in T cell activation adaptive immunity. ALPN-101 has demonstrated preliminary efficacy model graft versus host disease (GvHD) (2018 BMT abstract #244). Here we examined its efficacy, exposure, pharmacodynamics preparation for upcoming clinical...
Background: ALPN-101 (ICOSL vIgD-Fc) is an Fc fusion protein of a human inducible T cell costimulatory ligand (ICOSL) variant immunoglobulin domain (vIgD™) designed to inhibit simultaneously the CD28 and ICOS inflammation pathways (1). effective in preclinical studies lupus, arthritis, Sjögren’s, shows greater activity than single pathway inhibitors (2,3,4). It development for treatment multiple rheumatic other inflammatory diseases. Objectives: To evaluate safety, pharmacokinetics (PK),...