A5065745452- Mitochondrial Function and Pathology
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Metabolism and Genetic Disorders
- Ginseng Biological Effects and Applications
- Amino Acid Enzymes and Metabolism
- Aging, Elder Care, and Social Issues
- Pulmonary Hypertension Research and Treatments
- Salivary Gland Disorders and Functions
- Occupational and environmental lung diseases
- Cardiac tumors and thrombi
- Cardiomyopathy and Myosin Studies
- Plant Stress Responses and Tolerance
- Cholinesterase and Neurodegenerative Diseases
- Sleep and Wakefulness Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Immune cells in cancer
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Multiple Sclerosis Research Studies
- Genetic Associations and Epidemiology
- Genetic Neurodegenerative Diseases
- Oral Health Pathology and Treatment
- RNA regulation and disease
- Plant Molecular Biology Research
- Trace Elements in Health
Wuhan Prevention and Treatment Center for Occupational Diseases
2025
Yangzhou University
2024
Changchun University of Chinese Medicine
2024
Hainan University
2024
Shenyang Ninth People's Hospital
2024
Capital Medical University
2019-2023
Beijing Geriatric Hospital
2023
National Clinical Research Center for Digestive Diseases
2020-2023
Ministry of Education of the People's Republic of China
2023
Beijing Children’s Hospital
2019-2021
China has a large population of older people, but not yet undertaken comprehensive study on the prevalence, risk factors, and management both dementia mild cognitive impairment (MCI).For this national cross-sectional study, 46 011 adults aged 60 years or were recruited between March 10, 2015, Dec 26, 2018, using multistage, stratified, cluster-sampling method, which considered geographical region, degree urbanisation, economic development status, sex age distribution. 96 sites randomly...
To delineate the phenotypic and genotypic spectrum in carriers of mitochondrial MT-ATP6 mutations a large international cohort.We analyzed detail clinical, genetical, neuroimaging data from 132 mutation national registries local databases Europe, USA, Japan, China.We identified 113 clinically affected 19 asymptomatic individuals with known pathogenic mutation. The most frequent were m.8993 T > G (53/132, 40%), C (30/132, 23%), m.9176 m.9185 (12/132, 9%). degree heteroplasmy was high both...
It has been shown that glycolytic protein ENO1 (alpha-enolase) contributes to the pathogenesis of pulmonary hypertension through acting smooth muscle cells; however, roles ENO1-caused endothelial and mitochondrial dysfunctions in Group 3 remain unexplored. PCR array RNA sequencing were used screen decipher differential gene expression by hypoxia-treated human artery cells. Techniques small-interfering RNA, specific inhibitor plasmids carrying ENO1, interventions with AAV-ENO1 delivery...
Abstract Introduction The genetic risk effects of apolipoprotein E ( APOE ) on familial Alzheimer's disease (FAD) with or without gene mutations, sporadic AD (SAD), and normal controls (NC) remain unclear in the Chinese population. Methods In total, 15 119 subjects, including 311 FAD patients PSEN1, PSEN2, APP, TREM2 , SORL1 pathogenic mutations (FAD [unknown]); 126 PSENs / APP [ PSENs/APP ]); 7234 SAD patients; 7448 NC were enrolled. ε4 analyzed across groups. Results prevalence genotype...
Rosa rugosa is a representative aromatic species. Wild roses are known for their strong tolerance to highly salty environments, whereas cultivated varieties of exhibit lower salt stress tolerance, limiting development and industrial expansion. Previous studies have shown that C2H2-type zinc finger proteins play crucial role in plants’ resistance abiotic stresses. In this study, 102 genes (RrC2H2s) were identified R. via comprehensive approach. These categorized into three lineages, motif...
Abstract Background Multiple sclerosis (MS) is a chronic autoimmune neurodegenerative disease. Although some evidence indicates the potential involvement of cathepsins in MS process, precise nature this remains uncertain. The objective study was to ascertain whether there causal relationship between and MS. Methods This aimed examine nine MS, incorporating heterogeneity sensitivity analyses into design. MR reported according STROBE-MR checklist. Results analysis revealed cathepsin H (IVW:...
Abstract Background China has the largest population of patients with dementia and mild cognitive impairment (MCI) in world, imposing a heavy burden on public healthcare systems. The major concerns from health perspective include: prevalence, economic burden, risk factors, management strategy. Method Statistical analyses were performed most comprehensive MCI cohort study (fig. 1) China. Systemic review was also done studies past 10 years. Result For our data showed that, overall prevalence...
Abstract Background Most of the FDA approved drugs for AD are symptom driven and effects limited. Because is a complex disease involving multiple pathological changes, such as senile plaques formed by amyloid‐β (Aβ) deposition, neurofibrillary tangles caused tau hyperphosphorylation, microglia‐evoked neuroinflammation, synaptic degeneration, blood‐brain barrier (BBB) disruption. While current anti‐dementia mostly single targets, Chinese medicines have great development potential considering...
Objective To investigate the clinical significance of different samples (the peripheral blood, urine and skeletal muscle) that could be detected large-scale single deletions directly by using next-generation sequencing in diagnosis Kearns-Sayre syndrome (KSS) concluding genetic features KSS, order to explore a non-invasive method for diagnosis. Methods The data, muscle′s pathology enzymology results individuals with who were hospitalized from October 2016 2017 Department Neurology,...