A5025866676- Metabolism and Genetic Disorders
- Mitochondrial Function and Pathology
- Peripheral Neuropathies and Disorders
- Genetics and Neurodevelopmental Disorders
- Neurogenetic and Muscular Disorders Research
- Cancer-related molecular mechanisms research
- Autoimmune Neurological Disorders and Treatments
- RNA modifications and cancer
- Cytomegalovirus and herpesvirus research
- Multiple Sclerosis Research Studies
- Genomics and Rare Diseases
- Microplastics and Plastic Pollution
- Ferroptosis and cancer prognosis
- Metalloenzymes and iron-sulfur proteins
- Circular RNAs in diseases
- Lysosomal Storage Disorders Research
- Ion Transport and Channel Regulation
- Autoimmune and Inflammatory Disorders Research
- Blood Coagulation and Thrombosis Mechanisms
- Cellular transport and secretion
- Recycling and Waste Management Techniques
- Mycobacterium research and diagnosis
- ATP Synthase and ATPases Research
- Myasthenia Gravis and Thymoma
- Pharmacological Effects and Toxicity Studies
Beijing Children’s Hospital
2016-2025
Capital Medical University
2015-2025
Center for Children
2020-2024
Nanyang Technological University
2021-2024
Shandong University of Traditional Chinese Medicine
2022-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2020
University of Chinese Academy of Sciences
2016-2020
Jiangxi University of Traditional Chinese Medicine
2020
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2020
Peking Union Medical College Hospital
2020
Object detection has made great progress in the past few years along with development of deep learning. However, most current object methods are resource hungry, which hinders their wide deployment to many restricted usages such as on always-on devices, battery-powered low-end etc. This paper considers and accuracy trade-off for resource-restricted during designing whole framework. Based deeply supervised (DSOD) framework, we propose Tiny-DSOD dedicating usages. introduces two innovative...
To investigate whether the use of mycophenolate mofetil (MMF) could reduce relapse risk in patients with myelin oligodendrocyte glycoprotein (MOG)-immunoglobulin G (IgG)-associated disorders (MOGADs).This prospective observational cohort study included MOGAD at Peking Union Medical College Hospital between January 1, 2017, and April 30, 2019. The were divided into 2 groups: those (MMF+) or without (MMF-) MMF therapy. primary outcome was follow-up. We used Cox proportional hazards models to...
Microplastic fibers from textiles have been known to significantly contribute marine microplastic pollution. However, little is about the microfiber formation and discharge during textile production. In this study, we quantified emissions one large representative factory different stages, spanning seven materials, including cotton, polyester, blended fabrics, further guide control strategies. Wet-processing steps released up 25 times more microfibers than home laundering, with dyeing...
ABSTRACT Importance Anti‐neurofascin (anti‐NF) 155 antibody‐positive autoimmune nodopathy is a distinct subset of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Given the increase in pediatric cases, understanding this condition crucial. Objective This study aimed to delineate clinical features children with anti‐NF155 enhance disease management strategies. Methods We conducted retrospective cohort 34 CIDP patients admitted Beijing Children's Hospital from January 2015...
Familial hemophagocytic lymphohistiocytosis Type 2 (FHL2) associated central nervous system (CNS) involvement is less understood in children, especially when considering neurologic manifestations as part of the initial presentation. We conducted a retrospective review clinical and genetic abnormality four Han Chinese children with FHL2 who were patients at neurology department Beijing Children's Hospital from November 2015 to October 2018. These initially manifested CNS symptoms their...
Abstract There are two genetics complementary groups Cockayne syndrome type A and B (CS-A CS-B OMIM 216400, 133540), which is a rare autosomal recessive segmental progeroid syndrome. Homozygous or compound heterozygous mutations in the excision repair cross-complementation group 8 gene ( ERCC8 ) result CS-A, ERCC6 CS-B. ERCC6/ERCC8 also UV-sensitive In this study, twenty-one Han Chinese patients with CS were investigated to identify / , of thirteen cases CS-A identified . five types our such...
There are limit studies about pediatric brain abscess in China. The aim of this study was to analyze clinical characteristics and outcomes recent years China.The information children with hospitalized Beijing Children's Hospital between January 1, 2007 December 31, 2016 were retrospectively reviewed.Ninety-four enrolled study. A Streptococcus milleri group (13.8%) identified as the most common causative organisms, followed by Staphylococcus aureus (6.4%). overall mortality 21.6%, 50.0%...
Background: Antibodies against glutamic acid decarboxylase (GAD) are associated with various neurologic conditions described in patients, including stiff person syndrome, cerebellar ataxia, refractory epilepsy, and limbic extralimbic encephalitis. There have been some case reports investigations regarding anti-GAD65 antibody-associated encephalitis adult populations, but pediatric cases rare. We retrospectively analyzed the clinical data of three antibody-positive patients to explore...
Neuronal Ceroid Lipofuscinoses (NCLs) are progressive degenerative diseases mainly affect brain and retina. They characterised by accumulation of autofluorescent storage material, mitochondrial ATPase subunit C or sphingolipid activator proteins A D in lysosomes most cells. Heterogenous material NCLs is not completely disease-specific. Most CLN their natural substrates well characterized. Studies have suggested variants Late-Infantile (LINCLs) include the major type CLN2 minor types CLN5,...
BACKGROUND: Nowadays, stroke is a leading cause of disability in adults.Assessment motor performance has played an important role rehabilitation for post patients.Therefore, it quite to develop automatic assessment system function.OBJECTIVE: The purpose this study assess the single task upper-limb movements quantitatively among survivors.METHODS: Eleven normal subjects and thirty-five with were involved study.The subjects, who wearing micro-sensor motion capture system, performed shoulder...
Patients with hypoparathyroidism exhibit metabolic disorders (hypocalcemia) and brain structural abnormalities (brain calcifications). Currently, studies have determined whether antiepileptic drug (AED) treatment is required for epileptic seizures in children hypoparathyroidism. This study aims to evaluate the data of two medical centers Beijing based on diagnosis as first symptom children. A total 42 patients were included assigned into AED non-AED groups a 1:2 matched case–control study....
With the progress of times, social attention to mental health has been continuously improved, which led continuous development psychotherapy technology. Some newly developed treatment technologies have made up for limitations traditional technology and in many aspects major breakthroughs. Virtual reality is a recent years. It combines with adjust psychological disorders improve therapeutic effect.Virtual system good immersion, interactivity conception. At present, clinical psychologists...
Objective: Variant non-ketotic hyperglycinaemia (NKH) is a rare disorder characterized by variable clinical, biochemical, and imaging features. The variant form of NKH biochemical Subjects: Herein, we report girl with two mutations in glutaredoxin 5 ( GLRX5 ), which has been described only three patients. Results: clinical phenotypes the patient are also described. She suffered from developmental regression associated spasticity, delay, anemia optic atrophy. mitochondrial leukoencephalopathy...
The blood−spinal cord barrier (BSCB) is an effective, tightly-connected tissue that reduces secondary spinal injury (SCI) by decreasing blood cell infiltration, inflammation, and neuronal death during primary SCI. However, the methods molecular mechanisms of BSCB openness remain elusive. In present study, we found microRNA429 (miR-429) plays a vital role in opening cord. Inhibiting expression miR-429 (antagomiR-429) resulted increased levels tight junction (TJ) proteins, ZO-1, occludin,...
Ferredoxin reductase (FDXR), located in 17q25.1, encodes for a mitochondrial NADPH: adrenodoxin oxidoreductase or ferredoxin reductase, the sole human involved biosynthesis of iron-sulfur (Fe-S) clusters and heme formation. Iron-sulfur are enzymatic catalysis, gene expression, DNA replication repair. Variants FDXR lead to sensorial neuropathies, damage optic, auditory neurons. Here, we report Chinese boy with hearing loss, visual impairment, motor retardation, two novel compound heterozygous...
Abstract Aim To explore the clinical and genetic spectrum of hereditary spastic paraplegia (HSP) in Chinese children. Method This retrospective study was conducted between January 2014 October 2021 children clinically diagnosed with either pure HSP (pHSP) or complex (cHSP). Results We investigated 45 (32 males, 13 females; mean age [SD] at symptom onset 4 years [7 months]). identified causes 35 patients. Most patients autosomal dominant had pHSP (16/18), whereas most recessive tended to have...
Background: Immunogenic cell death (ICD) remodels the tumor immune microenvironment, plays an inherent role in apoptosis, and promotes durable protective antitumor immunity. Currently, appropriate biomarker-based ICD immunotherapy for breast cancer (BC) is under active exploration. Methods: To determine potential link between genes clinical risk of BC, TCGA-BC was used as training set GSE58812 validation set. Gene expression, consistent clustering, enrichment analysis, mutation omics...