A5057370077- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- MicroRNA in disease regulation
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Esophageal Cancer Research and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Wnt/β-catenin signaling in development and cancer
- Protease and Inhibitor Mechanisms
- HIV/AIDS Research and Interventions
- Pancreatic and Hepatic Oncology Research
- TGF-β signaling in diseases
- Peptidase Inhibition and Analysis
- DNA Repair Mechanisms
- FOXO transcription factor regulation
- Cancer Mechanisms and Therapy
- NF-κB Signaling Pathways
- Cancer Cells and Metastasis
- Melanoma and MAPK Pathways
- Endometriosis Research and Treatment
- Carcinogens and Genotoxicity Assessment
- interferon and immune responses
Shenyang The Fourth Hospital of People
2025
Hebei Medical University
2015-2024
Fourth Hospital of Hebei Medical University
2015-2024
Shenzhen Bioeasy Biotechnology (China)
2024
Shandong University of Traditional Chinese Medicine
2024
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2024
Jinzhou Medical University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2020
Second Hospital of Shandong University
2018
Institute of Microbiology
2011-2016
Mitogen-activated protein (MAP) kinase cascades represent one of the major signal systems used by eukaryotic cells to transduce extracellular signals into cellular responses. Four MAP subgroups have been identified in humans: ERK, JNK (SAPK), ERK5 (BMK), and p38. Here we characterize a new kinase, p38β. p38β is 372-amino acid most closely related It contains TGY dual phosphorylation site, which required for its activity. Like p38, activated proinflammatory cytokines environmental stress. A...
Abstract We developed stromal- and epithelial-specific cre-transgenic mice to directly visualize epithelial-mesenchymal transition (EMT) during cancer progression in vivo. Using three different oncogene-driven mouse mammary tumor models cell-fate mapping strategies, we show vivo evidence for the existence of EMT breast that myc can specifically elicit this process. Hierarchical cluster analysis genome-wide loss heterozygosity reveals incidence invasive human carcinomas is rare, but when it...
Abstract Maternally expressed gene 3 (MEG3), a long non-coding RNA (lncRNA), has tumor-suppressor properties and its expression is lost in several human tumors. However, biological role esophageal squamous cell carcinoma (ESCC) tumorigenesis poorly defined. The present study determined the methylation status of MEG3 cancer cells ESCC clinical specimens, further observed competing endogenous (ceRNA) activity pathogenesis development ESCC. Significant downregulation was detected tissues level...
An A to G transition at the 181 base pair position upstream of transcription initiation site matrix metalloproteinase-7 ( MMP-7 ) gene (−181A/G) may modify development and progression some diseases via influencing activity promoter. To assess effects functional single nucleotide polymorphism on cancer susceptibility progression, −181A/G genotypes were determined by polymerase chain reaction–restriction fragment length analysis among 258 patients with esophageal squamous cell carcinoma...
As an important long noncoding RNA, Hox transcript antisense intergenic RNA (HOTAIR) is involved in the development and progression of various carcinomas. However, role genetic alterations HOTAIR gastric cardia adenocarcinoma (GCA) occurrence have not been elucidated. We performed a case-control study population north China to evaluate possible association between haplotype-tagging SNPs (htSNPs) whole sequence risk GCA as well functional effect susceptibility single nucleotide polymorphism...
Abstract LINC00941 is a novel long noncoding RNA (lncRNA) and emerging as an important factor in cancer development. However, the exact function relative regulatory mechanism of carcinogenesis esophageal squamous cell carcinoma (ESCC) remain to be further clarified. The present study was investigate expression level, functions, mechanisms ESCC tumorigenesis. significantly upregulated ESCC, correlated with dismal patient outcomes. functioned oncogene by promoting cells proliferation,...
Abstract Natural antisense lncRNAs can interfere with their corresponding sense transcript to elicit concordant or discordant regulation. LncRNA ZNF667-AS1 and its gene ZNF667 were found be downregulated in esophageal squamous cell carcinoma (ESCC) tissues by RNA sequencing; however, the exact roles of both genes ESCC occurrence development have not been clarified. This study was investigate expression patterns, epigenetic inactivation mechanisms, function, prognostic significance...
Maternally expressed gene 3 (MEG3) is an imprinted located at 14q32 which encodes lncRNA and downregulated in expanding list of cancer cell lines primary human cancers. The miR-770 transcribed from the intronic sequence MEG3 may be host for miR-770. However, biological role gastric cardia adenocarcinoma (GCA) development prognosis poorly defined. present study was to investigate function methylation status GCA, further detect functional association its GCA carcinogenesis prognosis....
Abstract FcγR clustering in macrophages activates signaling events that result phagocytosis. Phagocytosis is accompanied by the generation harmful byproducts such as reactive oxygen radicals and production of inflammatory cytokines, which mandate phagocytic process be subject to a tight regulation. The molecular mechanisms involved this regulation are not fully understood. In study, we have examined role inositol 3-phosphatase tensin homologue deleted on chromosome 10 (PTEN) FcγR-induced...
Ets-2 is a transcriptional activator that can be modulated by ras-dependent phosphorylation. Evidence presented indicating ets-2 also act as repressor. In the breast cancer cell line MCF-7, exogenous repressed activity of BRCA1 promoter-luciferase reporter dependent on conserved ets-2-binding site in this promoter. Conditional overproduction MCF-7 cells resulted repression endogenous mRNA expression. To address mechanism which could repressor, biochemical approach was used to identify...
Fc gamma receptor (Fc R) clustering by immune complexes activates multiple signaling pathways leading to phagocytosis. We and others have previously reported that Akt is phosphorylated in response R clustering. However, the functional consequence of activation not known. Using Raw 264.7 macrophage cells transfected overexpress either constitutively active myristoylated (Myr)-Akt or a dominant-negative CAAX-Akt bone marrow macrophages (BMMs) from wild-type transgenic mice expressing...
The transcription factor ets-2 was phosphorylated at residue threonine 72 in a colony-stimulating 1 (CSF-1)- and mitogen-activated protein kinase-independent manner macrophages isolated from motheaten-viable (me-v) mice. CSF-1 target genes coding for Bcl-x, urokinase plasminogen activator, scavenger receptor were also expressed high levels independent of addition to me-v cells. Akt (protein kinase B) constitutively active macrophages, an immunoprecipitate catalyzed phosphorylation 72. p54...
The growth arrest DNA damage‐inducible gene (GADD45) family, which is composed of GADD45A, GADD45B, and GADD45G, may play similar but not identical roles in tumorigenesis. Genetic changes associated with or responsible for their dysregulation are general uncommon. This study was to detect the role GADD45 family gastric cardia adenocarcinoma (GCA) relationship GADD45A GADD45G methylation a series pathological parameters large GCA sample, order elucidate more information on regard pathogenesis...
BACKGROUND F‐box protein 32 (FBXO32) (also known as atrogin‐1), a member of the family, has recently been identified transforming growth factor beta (TGF‐β)/Smad target gene involved in regulating cell survival, and it may be transcriptionally silenced by epigenetic mechanisms some kinds carcinomas, yet its role esophageal squamous carcinoma (ESCC) not defined. METHODS The FBXO32 ESCC correlation methylation with series pathologic parameters were studied large cohort patients ESCC. RESULTS...
MiRNAs regulate gene expression and play pivotal roles in biological processes. can be inactivated by epigenetic mechanisms, such as DNA hypermethylation of CpG sites within islands. Here, we investigated the role methylation status miR-203a miR-203b esophageal cancer cell lines primary squamous carcinoma (ESCC) tumors further elucidate both miRNAs prognosis ESCC. The present study revealed a strong downregulation ESCC samples. Treatment cells with demethylating agent 5-Aza-dC led to...