A5060668466- Parasite Biology and Host Interactions
- Helminth infection and control
- Veterinary Oncology Research
- Infectious Diseases and Mycology
- Tuberculosis Research and Epidemiology
- Immune Cell Function and Interaction
- Mycobacterium research and diagnosis
- Virus-based gene therapy research
- Chronic Lymphocytic Leukemia Research
- Nematode management and characterization studies
- Aquatic Invertebrate Ecology and Behavior
- Zoonotic diseases and public health
- T-cell and Retrovirus Studies
- Environmental Toxicology and Ecotoxicology
- Microbial infections and disease research
- Retinoids in leukemia and cellular processes
- T-cell and B-cell Immunology
- Parasites and Host Interactions
- Veterinary Equine Medical Research
- Coccidia and coccidiosis research
- Forensic Entomology and Diptera Studies
- Cancer Research and Treatments
- Fish Ecology and Management Studies
- HIV Research and Treatment
- PI3K/AKT/mTOR signaling in cancer
The Ohio State University
2009-2023
Columbus Oncology and Hematology Associates
2013
University of Delaware
2012
Ohio University
2010
American College of Veterinary Pathologists
2007
University of Southern California
1994
Texas A&M University
1983-1991
Battelle
1983-1990
Knipling-Bushland U.S. Livestock Insects Research Laboratory
1986-1989
Syracuse University
1970
Currently, prognostic and therapeutic determinations for canine cutaneous mast cell tumors (MCTs) are primarily based on histologic grade. However, the use of different grading systems by veterinary pathologists institutional modifications make value highly questionable. To evaluate consistency microscopic among significance Patnaik system, 95 MCTs from dogs were graded in a blinded study 28 16 institutions. Concordance was 75% diagnosis grade 3 less than 64% 1 2 MCTs. improve concordance to...
IL-10 is a potent immunomodulatory cytokine that affects innate and acquired immune responses. The immunological consequences of production during pulmonary tuberculosis (TB) are currently unknown, although has been implicated in reactivation TB humans with disease mice. Using Mycobacterium tuberculosis-susceptible CBA/J mice, we show blocking the action vivo chronic infection stabilized bacterial load improved survival. Furthermore, this beneficial outcome was highly associated recruitment...
Rationale: An increase in the number of mononuclear phagocytes lung biopsies from patients with idiopathic pulmonary fibrosis (IPF) worsens prognosis. Chemokines that recruit phagocytes, such as CC chemokine ligand 2 (CCL2), are elevated bronchoalveolar lavage (BAL) fluid (BALF) IPF. However, little attention is given to role phagocyte survival and recruitment factor, macrophage colony-stimulating factor (M-CSF), fibrosis.Objectives: To investigate M-CSF fibrosis.Methods: Wild-type,...
Neoplastic diseases are typically diagnosed by biopsy and histopathological evaluation. The pathology report is key in determining prognosis, therapeutic decisions, overall case management therefore requires diagnostic accuracy, completeness, clarity. Successful relies on collaboration between clinical veterinarians, oncologists, pathologists. To date there has been no standardized approach or guideline for the submission, trimming, margin evaluation, reporting of neoplastic specimens...
Abstract Protective immunity and latent Mycobacterium tuberculosis infection in humans are associated with the formation of mature protective granulomas within lung. Unfortunately, understanding importance such structures has been hindered by lack small-animal models that can develop granulomas. In this article, we describe for first time, to our knowledge, mature, fibrotic M. tuberculosis–containing pulmonary a mouse model IL-10 deficiency (CBA/J IL-10−/−). Long-term control absence was...
Abstract CCL5-CCR5 interactions localize protective T cells to the lungs and contribute pulmonary granuloma formation control early infection with Mycobacterium tuberculosis. Control of M.tb, causative agent TB, requires immune cell recruitment form lung granulomas. The chemokines chemokine receptors that promote migration for formation, however, are not defined completely. As immunity M.tb manifests slowly in lungs, a better understanding specific roles chemokines, particular those...
Standardization of tumor assessment lays the foundation for validation grading systems, permits reproducibility oncologic studies among investigators, and increases confidence in significance study results. Currently, there is minimal methodological standardization assessing tumors veterinary medicine, with few attempts to validate published protocols schemes. The current article address these shortcomings by providing standard guidelines parameters evaluating specific types. More detailed...
Pathological evaluations were done on 205 rats with mononuclear cell leukemia. Leukemia was diagnosed in 22.2% of males and 20.4% females significant risk beginning at 20 months age. Mononuclear leukemia responsible for 50% early deaths two-year studies. Clinically, became depressed, pale, icteric had palpably enlarged spleens. Gross lesions included splenomegaly, mesenteric lymph nodes, mottled livers. Hemorrhages occurred the lungs, brain, nodes. Histological examination demonstrated that...
Germline mutations in the tumor suppressor gene PTEN (phosphatase and tensin homology deleted on chromosome 10) cause Cowden Bannayan–Riley–Ruvalcaba (BRR) syndromes, two dominantly inherited disorders characterized by mental retardation, multiple hamartomas, variable cancer risk. Here, we modeled three sentinel mutant alleles of identified patients with syndrome show that nonsense Pten ∆4–5 missense C124R G129E lacking lipid phosphatase activity similar developmental abnormalities but...
ABSTRACT Chronic skin wounds are a significant human health concern and often complicated by infection with Pseudomonas aeruginosa Staphylococcus aureus , particularly methicillin resistant S. (MRSA). Translating the knowledge gained from extensive study of virulence mechanisms pathogenesis these bacterial species to new treatment modalities has been lacking in part due paucity animal models able recapitulate disease. Our groups recently described novel porcine chronic burn wound model for...
Summary Diets incorporating three different sources of extracted cottonseed meal (CM), soybean and an animal protein mixture were evaluated for juvenile rainbow trout. Fish averaging 0.96 g divided into groups 30; 3 per treatment, each group was fed one four diets a 16‐week period. (FM) replaced on 25% basis by CM from California (CA), Tennessee (TN), Arkansas (AR), U.S.A. In the CM‐containing another 50% also incorporated to completely replace FM protein. The results growth rate feed...
Cardiac troponin I (cTnI) is used as a biomarker of myocardial injury in people and small animals. Little known about the diagnostic use cTnI cattle.Serum correlates to function histopathologic lesions cattle with monensin-induced injury.Ten healthy cows.Experimental study. Animals received 1 dose monensin PO; 30 mg/kg (n = 1) or 40 (Group A) 50 8) B) body weight. Repeated measurements were performed serum cTnI, biochemistry, ECG echocardiography until study termination at 80 144 hours after...
Hearts, diaphragms, esophagi, and spinal cords from 266 horses were obtained at slaughter in Creston, Ohio. Tissues examined microscopically for Sarcocystis sections, digested trypsin to obtain bradyzoites, fed 10 dogs cats. Intramuscular cysts found selections of two hearts 57 four esophagi 107 horses. The up 900 micron long 70 wide. cyst wall was 1 2 thick cross-striated. enclosed bradyzoites banana-shaped, 15 20 by 3 micron, contained several PAS-positive granules. Bradyzoites digests...
Tumor fibroblasts are active partners in tumor progression, but the genes and pathways that mediate this collaboration ill-defined. Previous work demonstrates Ets2 function stromal cells significantly contributes to breast progression. Conditional mouse models were used study of both mammary epithelial cells. inactivation PyMT ErbB2 driven tumors reduced growth, however deletion model had no significant effect. Analysis gene expression revealed a tumor- Ets2-dependent signature was enriched...
Abstract Mycobacterium bovis bacille Calmette Guerin (BCG), the current vaccine against infection with tuberculosis, offers a variable, protective efficacy in man. It has been suggested that exposure to environmental mycobacteria can interfere generation of BCG-specific immunity. We hypothesized following BCG vaccination would established immunity and reduce efficacy, thus modeling guidelines for within first year life. Mice were vaccinated subsequently given repeated oral doses live avium...
Complete hemograms were evaluated for 57 rats with mononuclear cell leukemia and compared to obtained from 52 age- sex-matched nonleukemic rats. All leukemic had marked hemolytic anemia associated spherocytosis, reticulocytosis, anisocytosis, polychromasia. The varied the stage of illness was more severe in rts advanced leukemia. Death appeared be related anemia. There a neutrophilia left shift, mild lymphopenia, moderate thrombocytopenia. Atypical cells detected circulation all but three...
The distribution and abundance of the nematode Camallanus oxycephalus infecting white bass, Morone chrysops, in western Lake Erie was studied for over 2 years. Infection generally more frequent higher intensity large fish. frequency distributions all segments fish population followed negative binomial distribution. data show seasonal cycles structure, site selection, infection, maturation, reproduction. occurs during July August with a resulting peak density; late summer autumn, mortality,...
ABSTRACT The expression of T cell differentiation markers is known to increase during Mycobacterium tuberculosis infection, and yet the biological role such remains unclear. We examined requirement marker killer lectin-like receptor G1 (KLRG1) M. infection using mice deficient in KLRG1. KLRG1 −/− had a significant survival extension after compared wild-type controls, maintained significantly lower level pulmonary throughout chronic infection. Improved control was associated with an increased...
Summary Effects of low-flow ischemia and reperfusion the large colon on mucosal architecture were determined in horses. Twenty-four adult horses randomly allocated to 3 groups: sham-operated (n = 6), 6 hours 9), 9). Low-flow was induced groups 2 by reducing colonic arterial blood flow 20% baseline values. Systemic hemodynamic metabolic variables maintained constant a normal physiologic range. Full-thickness biopsy specimens obtained from left ventral for histomorphologic morphometric...
Abstract Seventy‐six fathead minnows were exposed to 12 ppm cadmium for 96‐ h and examined histologically at 1‐wk intervals 30 d. Thirteen fish (17.1%) died during the exposure period. Lesions associated with acute toxicity epithelial necrosis of skin, oral cavity, gills, olfactory organs, kidney, urinary bladder, ureters, gastrointestinal tract, hemopoietic organ. The lesions most severe in which died. Survivors had similar but less extensive lesions. Residual minimal mild multifocal was...