Li Xu

ORCID: 0000-0003-1440-8923
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About
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Research Areas
  • Animal Nutrition and Physiology
  • Aquaculture Nutrition and Growth
  • Meat and Animal Product Quality
  • T-cell and B-cell Immunology
  • Sympathectomy and Hyperhidrosis Treatments
  • Antioxidant Activity and Oxidative Stress
  • Cytomegalovirus and herpesvirus research
  • Infant Nutrition and Health
  • Viral Infections and Immunology Research
  • Agriculture Sustainability and Environmental Impact
  • Agricultural Practices and Plant Genetics
  • Viral gastroenteritis research and epidemiology
  • Pituitary Gland Disorders and Treatments
  • Silk-based biomaterials and applications
  • Cytokine Signaling Pathways and Interactions
  • Food and Agricultural Sciences
  • Phytoestrogen effects and research
  • Extracellular vesicles in disease
  • Immunotherapy and Immune Responses
  • Moringa oleifera research and applications
  • Immune Cell Function and Interaction
  • Genetic and phenotypic traits in livestock
  • Whipple's Disease and Interleukins
  • Thyroid Disorders and Treatments
  • Biopolymer Synthesis and Applications

Zhejiang Chinese Medical University
2019-2024

First Affiliated Hospital of Fujian Medical University
2009-2023

Fujian Medical University
2009-2023

Northeast Agricultural University
2012-2022

China-Japan Friendship Hospital
2019

First Affiliated Hospital of Xi'an Jiaotong University
2010-2013

Soochow University
2013

The objective of this study was to evaluate the effects dietary Bacillus subtilis supplementation and calcium (Ca) levels on performance, eggshell quality, intestinal morphology, relative calbindin-D28k (CALB1) mRNA level laying hens in late phase production. An experiment employing a 2 × 3 factorial arrangement Ca (3.5, 4.0, 4.5%) absence or presence B. carried out with total 576 Hy-Line Brown aged 72 79 wk. Every group had 8 replicates 12 birds each. results showed that 4.0 4.5% improved...

10.1016/j.psj.2020.12.067 article EN cc-by-nc-nd Poultry Science 2020-12-30

Serum interleukin (IL)‑17A level is associated with higher microvessel density and poor prognosis in liver cancer. However, the specific mechanism underlying role of IL‑17A cancer remains controversial. In present study, effect on cells was examined. had no evident impact vascular endothelial growth factor A (VEGFA) production HepG2 Huh7.5 as determined by reverse transcription‑quantitative PCR ELISA, but it did stimulate angiogenic CXC chemokine secretion, including (C‑X‑C motif) ligand 1...

10.3892/mmr.2019.10310 article EN cc-by-nc-nd Molecular Medicine Reports 2019-05-29

Background . Refractory wound healing is a severe complication of diabetes with significant socioeconomic burden. Whereas current therapies are insufficient to accelerate repair, stem cell-based therapy increasingly recognized as an alternative that improves outcomes. The aim the present study explore role cycloastragenol (CAG), naturally occurring compound in Astragali Radix , ameliorating refractory cutaneous vitro, which may provide new insight into therapeutic strategy for diabetic...

10.1155/2019/7023950 article EN cc-by BioMed Research International 2019-12-20

Graves' disease (GD) is a common organ-specific autoimmune with the prevalence between 0.5 and 2% in women. Several lines of evidence indicate that shed A-subunit rather than full-length thyrotropin receptor (TSHR) autoantigen triggers autoimmunity leads to hyperthyroidism. We have for first time induced GD female rhesus monkeys, which exhibit greater similarity patients previous rodent models. After final immunization, monkeys injected adenovirus expressing TSHR (A-sub-Ad) showed some...

10.1530/joe-13-0279 article EN Journal of Endocrinology 2013-09-12

This study investigated the effects of dietary Enteromorpha powder supplementation on productive performance, egg quality, and antioxidant performance Zi geese during late laying period. Three hundred twelve (1 yr old) were randomly allocated into 2 cohorts to form a control group an experimental (with each cohort including 6 replicates 21 female 5 male in replicate). The was fed basal diet, diet containing 3% powder. data showed that significantly improved production, rate, average daily...

10.1016/j.psj.2019.10.003 article EN cc-by-nc-nd Poultry Science 2019-12-11

Eggshell color is an important characteristic for poultry eggs. Eggs from aged hens usually have poor shell that unacceptable the table egg market. The objective of this study was to examine effects pigment synthesis and mitochondrial biogenesis on brown eggshell laying hens. In trial, 8 eggs with darker lighter were selected 300 62-week-old Hy-Line brown-egg Results showed weight (P < 0.05), 0.01), protoporphyrin IX (Pp IX) content gland 0.001), biliverdin 0.001) significantly declined in...

10.1016/j.psj.2020.10.065 article EN cc-by-nc-nd Poultry Science 2020-11-11

To evaluate the effect of flavin-containing monooxygenase 3 (FMO3) genotype and dietary choline supplementation on trimethylamine (TMA) metabolism in HyLine Brown laying hens, a × 2 two-factorial arrangement was employed with FMO3 genotypes (AA, AT, TT) supplemental levels (370 2,960 mg/kg diet) as main effects. At 46 wk age, 108 hens AT TT were randomly allotted to one treatments, each treatment consisted 6 replicates 9 birds each. A total 24 AA treatments that hens. Hens fed diet 370 for 1...

10.3382/ps.2011-02074 article EN cc-by-nc-nd Poultry Science 2012-08-21

The objective of this study was to evaluate the effect dietary chloride (Cl) levels on performance, eggshell mechanical quality, and ultrastructure in layers based substitution sodium (NaCl) by sulfate (Na2SO4). Three hundred sixty Jing Brown laying hens aged 43 wk were randomly divided into 5 groups fed with corn–soybean meal diets containing 0.06, 0.10, 0.15, 0.20, 0.25% total Cl inclusion. Every group had 8 replicates 9 birds each. feeding trial lasted for 12 wk. results showed 0.06% due...

10.1016/j.psj.2019.10.030 article EN cc-by-nc-nd Poultry Science 2019-12-26

Enterovirus 71 (EV71), one of the major causative agents hand, foot, and mouth disease (HFMD), is now recognized as an emerging neurotropic virus in Asia may cause severe neurologic complications mortalities. Laboratory diagnosis EV71 infection must be efficient accurate, which could accomplished by various immunoassays. In this study we use a live isolate, Tainan/4643/98, with genotype C2 immunogen to sensitize BALB/c (H-2(d)) mice then generate EV71-specific murine monoclonal antibodies....

10.1089/mab.2013.0033 article EN Monoclonal Antibodies in Immunodiagnosis and Immunotherapy 2013-12-01

The objective of the present study was to evaluate effects hydroxylated lecithin on growth performance, serum enzyme activity, hormone levels related lipid metabolism and meat quality in Jiangnan White goslings. Six hundred 1-day-old goslings were randomly divided into five treatments with six replicates 20 for each replicate. control group (CG) fed basal diet, while experimental diet 50, 100, 200 mg/kg 100 soy (HLG50, HLG100, HLG200, LG100, respectively) form powder. Feed water provided ad...

10.3389/fvets.2022.829338 article EN cc-by Frontiers in Veterinary Science 2022-02-22

CD40 plays an important role in the pathogenesis of Graves' disease (GD). Inhibition expression may be a promising treatment for GD. In this study, we used animal model to investigate whether lentivirus expressing siRNA (LV-CD40-siRNA) could useful therapy BALB/c mice were injected with PBS alone (PBS group), negative (control or LV-CD40-siRNA (CD40 3 days before being treated adenovirus human TSHR A subunit (Ad-TSHR289) three times at 3-week intervals induce GD model. Sera thyroxine (T4)...

10.1677/joe-10-0224 article EN Journal of Endocrinology 2010-12-08

Objective: The effects of maternal dietary energy levels on breast muscle fibre development in offspring broiler breeders were investigated.Methods: A total 480 20-week-old Arbor Acres (AA) healthy female breeders, with an average body weight 2.33±0.01 kg, randomly divided into 4 treatment groups 6 replicates and 20 for each replicate fed a corn soybean meal diet 100%, 80%, 70%, 50% levels, respectively. Approximately 300 eggs per collected incubation days. Then, 120 0-day-old broilers at...

10.5713/ab.20.0712 article EN cc-by Animal Bioscience 2021-04-23

Abstract Non-small cell lung cancer (NSCLC) is among the most prevalent cancers and a leading cause of cancer-related mortality globally. Extracellular vesicles (EVs) derived from NSCLC play pivotal role in progression. Our findings reveal direct correlation between abundance EVs transfection efficiencies. Co-culturing two different lines could enhance formation, proliferation, migration tumorigenicity. mRNA chip metabolic analyses revealed significant alterations FOXO signaling pathway...

10.1038/s41419-024-06948-4 article EN cc-by Cell Death and Disease 2024-07-31

The aim of this study was to investigate the effects Enteromorpha powder supplementation on reproduction-related hormones and genes in late laying period Zi geese.

10.5713/ajas.20.0368 article EN cc-by Animal Bioscience 2020-08-29

Abstract Background Primary focal hyperhidrosis (PFH) may be attributed to the up-regulation of cholinergic receptor nicotinic alpha 1 subunit (CHRNA1) in eccrine glands. Plasminogen activator inhibitor-1 (PAI1, encoded by SERPINE1 ) is reported inhibit expression CHRNA1, while role PAI1 unknown. Methods Serpine1 KO mice, -Tg and wild type BALB/c mice were intraperitoneally injected with pilocarpine hydrochloride induce PFH. Cisatracurium (CIS, antagonist CHRNA1) or PAI-039 (small-molecule...

10.1186/s13023-023-02808-0 article EN cc-by Orphanet Journal of Rare Diseases 2023-07-21

Objective To observe the characteristics of cerebral regional blood flow (rCBF) in patients with palmar hyperhidrosis,and to explore passible mechanism for development pal-mar hyperhidrosis. Methods SPECT 99Tcm-ECD was used quantitatively determine rCBF hyperhidrosis who underwent endoscopic thoracic sympathectomy. The preoperative mode analyzed, and postoperative compared. Results one later-al high zone observed at basal nucleus area 9 cases out 10 cases. zones significantly decreased after...

10.3760/cma.j.issn.1001-9030.2009.04.032 article EN Zhonghua shiyan waike zazhi 2009-04-08
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