A5101912538- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Radiomics and Machine Learning in Medical Imaging
- Gastric Cancer Management and Outcomes
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Appendicitis Diagnosis and Management
- Soil and Unsaturated Flow
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
- Lung Cancer Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Cell death mechanisms and regulation
- Irrigation Practices and Water Management
- TGF-β signaling in diseases
- Acute Myeloid Leukemia Research
- Dam Engineering and Safety
- Acute Lymphoblastic Leukemia research
- T-cell and B-cell Immunology
- Esophageal Cancer Research and Treatment
- Cancer therapeutics and mechanisms
- Respiratory Support and Mechanisms
Soochow University
2011-2025
Nanjing Medical University
2015-2025
Nanjing University of Chinese Medicine
2024-2025
University of Macau
2024-2025
Jiangsu Province Hospital
2015-2025
CM Hospital
2025
Quality Research
2024
Institute of Soil and Water Conservation
2024
Northwest A&F University
2018-2024
Guangdong Academy of Medical Sciences
2022-2024
Accurate prediction of treatment response to neoadjuvant chemotherapy (NACT) in individual patients with locally advanced gastric cancer (LAGC) is essential for personalized medicine. We aimed develop and validate a deep learning radiomics nomogram (DLRN) based on pretreatment contrast-enhanced computed tomography (CT) images clinical features predict the NACT LAGC.719 LAGC were retrospectively recruited from four Chinese hospitals between Dec 1st, 2014 Nov 30th, 2020. The training cohort...
Regulatory T (Treg) cells may participate in mediating a suppressive microenvironment that blunts successful anti-tumor immunotherapy. Recent studies show CD8+ Treg might impede effective immune responses to established tumors. However, there is limited research regarding ovarian cancer (OC) patients. Here, we investigated OC patients and their vitro induction. The immunohistochemistry of tumor-infiltrating lymphocytes revealed significant correlation between the intratumoral forkhead box p3...
Colorectal cancer (CRC), a common tumor, is characterized by high mortality rate. Long non-coding RNA maternally expressed gene 3 (MEG3) serves regulatory role in the carcinogenesis and progression of several types cancer; however, its CRC remains largely unknown. The aim this study was to explore mechanism(s) MEG3 CRC. Warburg effect or aerobic glycolysis characteristic metabolism tumor cells. To determine on cells, we used an XF analyzer perform stress test assays found that overexpression...
Abstract Loss of the B2M gene is associated with tumour immune escape and resistance to immunotherapy. However, genetic alterations are rare. We performed an integrative analysis mutational transcriptional profiles large cohorts non‐small‐cell lung cancer (NSCLC) patients found that epigenetic downregulation common. B2M‐low tumours exhibit a suppressive microenvironment characterized by reduced infiltration cells various lineages; in B2M‐high tumours, more T natural killer present, but their...
Studies have shown that magnetic resonance imaging (MRI)-based deep learning radiomics (DLR) has the potential to assess glioma grade; however, its role in predicting telomerase reverse transcriptase (TERT) promoter mutation status patients with glioblastoma (GBM) remains unclear.To evaluate value of (DL) multiparametric MRI-based identifying TERT mutations GBM preoperatively.Retrospective.A total 274 isocitrate dehydrogenase-wildtype were included study. The training and external validation...
Background Mutations in the PHF6 gene were recently described patients with T-cell acute lymphoblastic leukemia and those myeloid leukemia. The present study was designed to determine prevalence of alterations leukemia.Design Methods We analyzed incidence prognostic value mutations 96 Chinese deletions screened by real-time quantitative polymerase chain reaction array-based comparative genomic hybridization. Patients also investigated for NOTCH1, FBXW7, WT1, JAK1 together CALM-AF10,...
SummaryBackgroundEarly prediction of lymph node status after neoadjuvant chemotherapy (NAC) facilitates promptly optimization treatment strategies. This study aimed to develop and validate a deep learning network (DLN) using baseline computed tomography images predict metastasis (LNM) NAC in patients with locally advanced gastric cancer (LAGC).MethodsA total 1205 LAGC were retrospectively recruited from three hospitals between January 2013 March 2023, constituting training cohort, an...
<title>Abstract</title> <bold>Background</bold> Impaired colonic mucosal repair is a critical issue in inflammatory bowel diseases (IBD). SATB2 essential for maintaining epithelial homeostasis, but its role unclear.<bold>Objective</bold> To investigate how deficiency impairs IBD and assess the therapeutic potential of peptide YY (PYY) enhancing regeneration.<bold>Design</bold> Flow cytometry was used to SATB2’s radiation injury model. knockout mice were validate impairment. The effect loss...
<title>Abstract</title> Objectives To retrospectively evaluate the potential role of an obscured appendiceal wall on unenhanced CT in preoperative prediction complicated appendicitis. Methods This retrospective study was approved by our institutional review board, and informed consent waived. A total 57 patients with surgically pathologically confirmed appendicitis were analyzed from January 1, 2021, to June 30, 2024. The assessed alongside four other specific findings clinical data....
The G‐quadruplex (G4) is an important diagnostic and therapeutic target in cancers, but the development of theranostic probes for subcellular G4s remains challenging. In this work, we report three G4‐targeted by conjugating a pyridostatin‐derived G4 ligand to G4‐specific iridium(III) complexes with desirable photophysical properties. These showed specifically enhanced luminescence mitochondrial triple negative breast cancer (TNBC) cells. Of note, complex 3 exhibited NIR emission ability...
Abstract Inflammatory bowel disease (IBD) is a chronic disorder linked to an increased risk of colorectal cancer (CRC) and characterized by significant dysbiosis in the gut microbiota. The commensal bacterium Parabacteroides goldsteinii ( P. ) has shown potential modulating host metabolism inflammatory responses. In this study, we investigated probiotic properties its mechanism action IBD models, with particular focus on bile acid diet‐microbiota interactions. Fecal samples from patients...
Non-small cell lung cancer (NSCLC) is the leading cause of death worldwide. Clinical and laboratory studies have suggested that multi-targeting approaches against neoplastic cells could help to increase patient survival might reduce emergence are resistant single-target inhibitors. Artesunate (ART) one most potent rapidly acting antimalarial agents known, it also exerts a profound cytotoxic activity toward reverses multi-drug resistance. In present study, we found artesunate inhibited NSCLC...
// Peng Song 1,* , Lei Wu 2,* Bo Jiang Zhijian Liu 1 Ke Cao 3 and Wenxian Guan Department of General Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital University Medical School, Nanjing, China 2 Laboratory Medicine, First University, Critical Care * These authors have contributed equally to this work Correspondence to: Guan, email: Keywords : age; prognosis; gastric cancer; SEER Received November 16, 2015 Accepted April 29, 2016 Published May 21, Abstract Prognosis age at...
Background: M2 macrophages are well accepted to promote cancer progression in the prostate (PCa). Paracrine is principally studied mode of communication between and tumor cells. In addition this, we present here a novel model demonstrate these cellular communications. Methods: PCa cells were co-cultured with THP-1/ human peripheral blood mononuclear derived direct contact manner. Cancer cell proliferation invasion examined explain how communicates. Cell-based findings validated two xenograft...
To date, no drug therapy has shown significant efficacy in improving functional outcomes patients with acute spinal cord injury (SCI). Riluzole is an approved benzothiazole sodium channel blocker to attenuate neurodegeneration amyotrophic lateral sclerosis (ALS) and of interest for neuroprotection SCI. In a Phase I clinical trial (ClinicalTrials.gov Identifier: NCT00876889), riluzole was well tolerated 2-week treatment at the dose level ALS exhibited potential The progressive nature...
Background: Immune checkpoint blockers (ICBs) are increasingly being used to treat patients with advanced hepatocellular carcinoma (HCC), but only a third of these sensitive ICBs. Emerging evidence suggests that ferroptosis could be novel target for antitumor treatment, and combined treatment inducers might enhance sensitivity immunotherapy. However, there is lack information on the crosstalk between ferroptosis-related lncRNAs anti-tumor immunity. Therefore, we aim explore prognostic value...
E2F transcription factor 3 (E2F3) plays a vital role in the development of various types cancer. To verify whether E2F3 is suitable biomarker for prognosis lung cancer, bioinformatics analysis was performed to determine differential expression level cancer and surrounding non‑tumor tissues, results were confirmed NSCLC cell line tissue microarray (TMA). The relevance non‑small (NSCLC) investigated 19 studies from Oncomine database Cancer Genome Atlas database. In A549, inhibition mRNA led...
The precise cytotoxicity of E. Adenophorum in relation to the cell cycle and apoptosis splenocytes Saanen goats remains unclear. In present study, 16 were randomly divided into four groups, which fed on 0%, 40%, 60% 80% adenophorum diets. results TUNEL, DAPI AO/EB staining, flow cytometry analysis DNA fragmentation assays showed that induced typical apoptotic features splenocytes, suppressed splenocyte viability, caused arrest a dose-dependent manner. However, westernblot, ELISA, qRT-PCR...