Zhongkai Wang

ORCID: 0000-0003-0578-5735
Publications
Citations
Views
---
Saved
---
About
Contact & Profiles
Research Areas
  • Genomics and Phylogenetic Studies
  • Invertebrate Immune Response Mechanisms
  • Genetic diversity and population structure
  • Chromosomal and Genetic Variations
  • Aquaculture disease management and microbiota
  • Crustacean biology and ecology
  • Adsorption and biosorption for pollutant removal
  • Bone Tissue Engineering Materials
  • Plant Virus Research Studies
  • Genetic and phenotypic traits in livestock
  • Ichthyology and Marine Biology
  • Nanomaterials for catalytic reactions
  • Machine Learning in Bioinformatics
  • Graphene and Nanomaterials Applications
  • RNA and protein synthesis mechanisms
  • Venomous Animal Envenomation and Studies
  • interferon and immune responses
  • Biochemical and Structural Characterization
  • Subterranean biodiversity and taxonomy
  • Marine Ecology and Invasive Species
  • Fish biology, ecology, and behavior
  • Clay minerals and soil interactions
  • Developmental Biology and Gene Regulation
  • Silk-based biomaterials and applications
  • Coleoptera Taxonomy and Distribution

Northwestern Polytechnical University
2018-2025

Fourth Hospital of Hebei Medical University
2025

Hebei Medical University
2025

South China Normal University
2022

Guangxi University
2020-2021

Jiangsu University
2021

University of Chinese Academy of Sciences
2015

Phylogeny and characteristics of ruminants Ruminants are a diverse group mammals that includes families containing well-known taxa such as deer, cows, goats. However, their evolutionary relationships have been contentious, the origins distinctive digestive systems headgear, including antlers horns (see Perspective by Ker Yang). To understand among ruminants, L. Chen et al. sequenced 44 species representing 6 performed phylogenetic analysis. From this analysis, they were able to resolve...

10.1126/science.aav6202 article EN Science 2019-06-20

Abstract Artificially improving traits of cultivated alfalfa ( Medicago sativa L.), one the most important forage crops, is challenging due to lack a reference genome and an efficient editing protocol, which mainly result from its autotetraploidy self-incompatibility. Here, we generate allele-aware chromosome-level assembly for consisting 32 allelic chromosomes by integrating high-fidelity single-molecule sequencing Hi-C data. We further establish CRISPR/Cas9-based protocol on basis this...

10.1038/s41467-020-16338-x article EN cc-by Nature Communications 2020-05-19

Abstract Background The swimming crab, Portunus trituberculatus, is an important commercial species in China and widely distributed the coastal waters of Asia-Pacific countries. Despite increasing interest crab research, a high-quality chromosome-level genome still lacking. Findings Here, we assembled first reference P. trituberculatus by combining short reads, Nanopore long Hi-C data. assembly size was 1.00 Gb with contig N50 length 4.12 Mb. In addition, BUSCO assessment indicated that...

10.1093/gigascience/giz161 article EN cc-by GigaScience 2020-01-01

Abstract The evolutionary and genetic origins of the specialized body plan flatfish are largely unclear. We analyzed genomes 11 species representing 9 14 Pleuronectiforme families conclude that Pleuronectoidei Psettodoidei do not form a monophyletic group, suggesting independent from different percoid ancestors. Genomic transcriptomic data indicate genes related to WNT retinoic acid pathways, hampered musculature reduced lipids might have functioned in evolution Pleuronectoidei. Evolution...

10.1038/s41588-021-00836-9 article EN cc-by Nature Genetics 2021-04-19

As an important freshwater aquaculture species in China, the Chinese mitten crab (Eriocheir japonica sinensis) has high economic and nutritional value. However, limited genomic information is currently available for studying its basic development genetic diversity. Here, we performed whole-genome sequencing on Oxford Nanopore Technologies Limited's platform using promethION. The assembled size of E. j.sinensis genome was approximately 1.27 Gb, which close to estimated (1.19 Gb). Furthermore,...

10.3389/fgene.2019.01340 article EN cc-by Frontiers in Genetics 2020-01-17

<title>Abstract</title> Crabs encompass the infra-orders Brachyura and Anomura, collectively constitute clade Meiura within order Decapoda. Despite their considerable diversity, genomic resources for crabs remain scarce, hindering our understanding of phylogeny genetic mechanisms underlying such unique traits as carcinization. To address these questions, here we sequenced genomes 10 crab species covering all currently controversial taxonomies at section level. Our whole-genome phylogenetic...

10.21203/rs.3.rs-5612812/v1 preprint EN cc-by Research Square (Research Square) 2025-01-10

Abstract Background Taxus wallichiana is an important species for paclitaxel production. Previous genome versions spp. have been limited by extensive gaps, hindering the complete annotation and mining of (known as Taxol commercially) synthesis pathway-related genes. Results Here, we present first phased high-quality reference T. wallichiana, which significantly improves assembly quality corrects large-scale errors in previous versions. The 2 haplotypes are 9.87 Gb 9.98 length, respectively,...

10.1093/gigascience/giaf026 article EN cc-by GigaScience 2025-01-01

Abstract The reissner lamprey Lethenteron reissneri , belonging to the class Cyclostomata, serves as a bridge between invertebrates and jawed vertebrates, is considered sister group of vertebrates. However, despite this evolutionary significance, genetic mechanisms underlying adaptive evolution lineage remain unclear. Here, we assembled 1.06 Gb chromosome‐level draft genome L. with 72 chromosomes (ranging in length from 4.5 Mb 25.9 Mb) scaffold N50 13.23 Mb. Genome quality comparisons...

10.1111/1755-0998.13279 article EN Molecular Ecology Resources 2020-10-14

The mustache toad, Vibrissaphora ailaonica, is endemic to China and belongs the Megophryidae family. Like other toad species, V. ailaonica males temporarily develop keratinized nuptial spines on their upper jaw during each breeding season, which fall off at end of season. This feature likely result reversal sexual dimorphism in body size, with being larger than females. A high-quality reference genome for would be invaluable investigate genetic mechanism underlying these repeatedly...

10.1093/gigascience/giz114 article EN cc-by GigaScience 2019-09-01

Abstract Background The black widow spider has both extraordinarily neurotoxic venom and three-dimensional cobwebs composed of diverse types silk. However, a high-quality reference genome for the was still unavailable, which hindered deep understanding application valuable biomass. Findings We assembled Latrodectus elegans genome, including size 1.57 Gb with contig N50 4.34 Mb scaffold 114.31 Mb. Hi-C scaffolding assigned 98.08% to 14 pseudo-chromosomes, BUSCO, completeness analysis revealed...

10.1093/gigascience/giac049 article EN cc-by GigaScience 2022-01-01

Gobiocypris rarus is sensitive to environmental pollution, especially heavy metal and grass carp reovirus (GCRV). Hence, it has potential utility as a biological monitor. Genetic deciphering of its unique immune system will advance our understanding adaptive strategies, which provide cues for better application. A de novo genome rare minnow was obtained, sex determination mechanism ZZ/ZW. We identified several specific mutation genes lost minnow, these might be related the sensitivity...

10.1126/sciadv.abl7253 article EN cc-by-nc Science Advances 2022-02-02

Abstract Horseshoe crabs including Tachypleus tridentatus are a group of marine arthropods and living fossil species which have existed on the earth for ~500 million years. However, genetic mechanisms underlying their unique adaptive ability still unclear. Here, we assembled first chromosome‐level T. genome, proved that this genome is high quality with contig N50 1.69 Mb. By comparison other arthropods, some gene families experienced significant expansion, related to several signaling...

10.1111/1755-0998.12988 article EN Molecular Ecology Resources 2018-12-28

Abstract The blue king crab, Paralithodes platypus , which belongs to the family Lithodidae, is a commercially and ecologically important species. However, high‐quality reference genome for crab has not yet been reported. Here, we assembled first chromosome‐level genome, contains 104 chromosomes an N50 length of 51.15 Mb. Furthermore, determined that large size can be attributed insertion long interspersed nuclear elements tandem repeats. Genome assembly assessment showed 96.54% transcripts...

10.1111/1755-0998.13266 article EN cc-by Molecular Ecology Resources 2020-10-03

The ladybird beetle Henosepilachna vigintioctomaculata is an economically significant oligophagous pest that induces damage to many Solanaceae crops. An increasing number of studies have examined the population and phenotype diversity beetles. However, few comparative genome analyses species been conducted. Here, we obtained a high-quality chromosome-level assembly H. using various sequencing technologies, was ~581.63 Mb, with 11 chromosomes successfully assembled. phylogenetic analysis...

10.1093/dnares/dsad001 article EN cc-by-nc DNA Research 2023-01-16

A graphene oxide nanocomposite (GO‐Fe 3 O 4 ) was synthesized with a simple and low‐cost method. This characterized by XRD, TEM, FT‐IR, TGA, VSM. Spherical Fe nanoparticles an average size of 10 nm were uniformly applied to the surface sheets. GO‐Fe showed superparamagnetic characteristic at room temperature its saturation magnetization 8.5 · M 2 /kg. The adsorption behaviour diquat investigated, including effects pH, temperature, water matrix. kinetics, thermodynamics, isotherm also...

10.1002/cjce.22278 article EN The Canadian Journal of Chemical Engineering 2015-07-15

Abstract Background Semiothisa cinerearia belongs to Geometridae, which is one of the most species-rich families lepidopteran insects. It also economically significant pests Chinese scholar tree ( Sophora japonica L.), an important urban greenbelt trees in China due its high ornamental value. A genome assembly S. would facilitate study control and evolution this species. Results We present a reference for ; size was ~ 580.89 Mb, it contained 31 chromosomes. Approximately 43.52% sequences...

10.1186/s12864-022-08949-z article EN cc-by BMC Genomics 2022-10-21

Origination of new genes are inherent interest evolutionary geneticists for decades, but few studies have addressed the general pattern in a fish lineage. Using our recent released whole genome data flatfishes, which evolved one most specialized body plans vertebrates, we identified 1541 (6.9% starry flounder genes) flatfish-lineage-specific genes. The origination these flatfish is largely similar to those observed other as shown by proportion DNA-mediated duplication (1317; 85.5%),...

10.3390/genes12111819 article EN Genes 2021-11-19

Abstract Diamondback terrapins ( Malaclemys terrapin centrata ) exhibit strong environmental adaptability and live in both freshwater saltwater. However, the genetic basis of this has not been focus research. In study, we successfully constructed a ∼2.21‐Gb chromosome‐level genome assembly for M. t. using high‐coverage high‐depth genomic sequencing data generated on multiple platforms. The contains 25 chromosomes scaffold N50 ∼143.75 Mb, demonstrating high continuity accuracy. total, 53.82%...

10.1111/1749-4877.12898 article EN Integrative Zoology 2024-10-11

Land hermit crabs are a group of shell-carrying that have evolved remarkable terrestrial adaptations in behavior, morphology, physiology, and biochemistry. However, the genetic mechanisms underlying these remain unclear. In addition, usually it is very difficult to get good genome assemblies for crustaceans. this study, we managed assemble first chromosome-level land crab (Coenobita brevimanus) with careful manual curation. The final assembly spans 4.74 Gb, contig N50 1.75 Mb scaffold 42.95...

10.1038/s41597-024-04031-3 article EN cc-by-nc-nd Scientific Data 2024-11-02
Coming Soon ...