A5101029382- Skin and Cellular Biology Research
- Plant Reproductive Biology
- Bioinformatics and Genomic Networks
- Genomics and Phylogenetic Studies
- Hair Growth and Disorders
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Wound Healing and Treatments
- T-cell and Retrovirus Studies
- Molecular Biology Techniques and Applications
- Virus-based gene therapy research
- Study of Mite Species
- Machine Learning in Bioinformatics
- Advanced Cellulose Research Studies
- Electromagnetic Simulation and Numerical Methods
- Legume Nitrogen Fixing Symbiosis
- Berberine and alkaloids research
- Lung Cancer Treatments and Mutations
- Genetic Mapping and Diversity in Plants and Animals
- Infrared Target Detection Methodologies
- Viral Infections and Outbreaks Research
- Thyroid and Parathyroid Surgery
- Biofuel production and bioconversion
- Microbial infections and disease research
- Genetic diversity and population structure
Tianjin Institute of Industrial Biotechnology
2025
Chinese Academy of Sciences
2025
Anhui Medical University
2024
China Medical University
2021-2023
Capital Normal University
2019-2022
North Carolina State University
2022
Shanghai Public Security Bureau
2021
Shangrao Normal University
2018-2020
Zhongda Hospital Southeast University
2020
Hunan University
2020
Human T-cell leukemia and acute lymphoblastic cell lines were studied for alterations in the p53 tumor suppressor gene. Southern blot analysis of 10 leukemic revealed no gross genomic deletions or rearrangements. Reverse transcription-polymerase chain reaction mRNA indicated that all produced normal size. By direct sequencing polymerase reaction-amplified cDNA, we detected 11 missense nonsense point mutations 5 studied. The are primarily located evolutionarily highly conserved regions One...
Abstract Background Taxus wallichiana is an important species for paclitaxel production. Previous genome versions spp. have been limited by extensive gaps, hindering the complete annotation and mining of (known as Taxol commercially) synthesis pathway-related genes. Results Here, we present first phased high-quality reference T. wallichiana, which significantly improves assembly quality corrects large-scale errors in previous versions. The 2 haplotypes are 9.87 Gb 9.98 length, respectively,...
Various computational models have been developed to transfer annotations of gene essentiality between organisms. However, despite the increasing number microorganisms with well-characterized sets essential genes, selection appropriate training for predicting genes poorly-studied or newly sequenced organisms remains challenging. In this study, a machine learning approach was applied reciprocally predict in 21 microorganisms. Results showed that set greatly influenced predictive accuracy. We...
In this study, whole genome sequencing and comparative genomic analyses were performed for Mucilaginibacter polytrichastri RG4-7 its carboxymethyl cellulose degradation potential was assessed. The results showed that the of strain 5.84 Mb contained 5019 predicted genes, in which a high proportion strain-specific genes related to carbohydrate metabolism. (CMC) cellulase activity tests revealed strong ability, CMCase β-glucosidase RG4-7. Real-time RT-PCR testing most glycoside hydrolase (GH)...
Abstract Background Determination of the minimum gene set for cellular life is one central goals in biology. Genome-wide essential identification has progressed rapidly certain bacterial species; however, it remains difficult to achieve most eukaryotic species. Several computational models have recently been developed integrate features and used as alternatives transfer essentiality annotations between organisms. Results We first collected that were widely by previous predictive assessed...
Several biclustering algorithms have been proposed to identify biclusters, in which genes share similar expression patterns across a number of conditions. However, different would yield biclusters and further lead distinct conclusions. Therefore, some testing comparisons between these are strongly required.In this study, five (i.e. BIMAX, FABIA, ISA, QUBIC SAMBA) were compared with each other the cases where they used handle two datasets (GDS1620 pathway) dimensions Arabidopsis thaliana (A....
Senecavirus A (SVA), an emerging RNA virus, is considered to be associated with porcine idiopathic vesicular disease (PIVD). From February September 2017, 17 novel SVA strains were isolated from samples the Guangdong Province, China. Full-length genomes and individual genes of new isolates genetically phylogentically analyzed. Results showed that complete genomes, VP1, 3C, 3D these revealed 96.5-99.8%, 95.1-99.9%, 95.6-100%, 96.9-99.7% nucleotides identities, respectively. Phylogenetic...
We report here the amplification and sequence analysis of two complete genomes newly emerged porcine deltacoronavirus (PDCoV) strains, isolated from diarrhea samples piglets in Guangdong Province southern China. These provide further data for evaluating relationships among PDCoVs different countries.
Assessment of the bacterial diversity associated with a decaying fern, Athyrium wallichianum Ching, revealed presence novel strain named M46T. It was Gram-stain-negative, rod-shaped, non-motile and aerobic cellulose xylan degradation abilities. Phylogenetic analysis based on 16S rRNA gene sequences showed that M46T affiliated to genus Sphingobacterium, exhibiting highest sequence similarity 97.9 % Sphingobacterium ginsenosidimutans THG 07T, canadense CR11T detergens6.2 ST. Multilocus (MLSA)...
Krabbe disease (KD), also referred to as globoid cell leukodystrophy, is a rare autosomal recessive lysosomal storage disorder caused by β-galactocerebrosidase (GALC) deficiency. Most patients affected this are infants, and <10% of cases suffer from adult-onset KD. In study, two Chinese males presented with long-term progressive weakness in their limbs. Magnetic resonance imaging the brain spinal cord these revealed lesions abnormally high signal intensity on T2-weighted (T2W) T2W...
Abstract MicroRNAs (miRNAs) are a class of small non-coding RNAs that exert their biological functions as negative regulators gene expression. They involved in the skin wound healing process with dynamic expression pattern and can therefore potentially serve biomarkers for age estimation. However, no reports have described any miRNAs suitable reference genes (RGs) miRNA quantification wounded or samples post-mortem changes. Here, we aimed to identify specific RGs support further studies...
Increasing drug efflux pumps (P-gp) on the cell membrane due to overexpression of MDR1 gene in tumor cells is main mechanism multidrug resistance cancer cells. P-gp belongs ATP-binding cassette family and functions as a transmembrane pump that translocates chemotherapy drugs from an intracellular extracellular domain; thus, it impossible achieve efficient accumulation Tetrandrine (TTD) has been shown both vitro animal experiments reverse MDR by reducing expression mRNA P-gp. However, effect...
The water mite Unionicola penicillatus (Wen, Gao & Zhu) (Acari: Unionicolidae) was collected in freshwater bivalve Cristaria plicata (Unionidae). population variation of U. investigated 504 bivalves during the period from August 2013 to July 2014 Poyang Lake, East China. results indicated that overall prevalence and abundance 9.52% 1.58±10.38. highest 58.70% September. levels were observed when length 220–300 mm. number a host not correlated with sex bivalves. outer inner gills preferred...
Abstract Background: Genomic selection has been implemented in livestock genetic evaluations for years. However, currently most genomic models only consider the additive effects associated with SNP markers and nonadditive have part ignored. Methods: Production traits 26,735 to 27,647 Duroc pigs reproductive 5,338 sows were used, including off-test body weight (WT), back fat (BF), loin muscle depth (MS), number born alive (NBA), dead (NBD), weaned (NW). All animals genotyped PorcineSNP60K...
Wound age estimation is one of the major tasks in forensic practice. However, relatively accurate wound still a conundrum and research spotlight world-widely. Studies show that microRNAs (miRNAs) are involved whole process skin repair, miRNAs, as biomarkers, might be used to estimate time injury owing their characteristic advantage. This paper summarizes miRNA fundamental function, properties, current progress age, its limitations, put forward prospect potential application based on miRNAs...