A5003292348- Protein Degradation and Inhibitors
- CAR-T cell therapy research
- Pomegranate: compositions and health benefits
- Multiple Myeloma Research and Treatments
- Nuclear Receptors and Signaling
- Airway Management and Intubation Techniques
- Vascular Anomalies and Treatments
- Cancer Immunotherapy and Biomarkers
- Genetic factors in colorectal cancer
- Cryptography and Data Security
- Phytochemistry Medicinal Plant Applications
- Tracheal and airway disorders
- Drug Transport and Resistance Mechanisms
- Complexity and Algorithms in Graphs
- Cryptography and Residue Arithmetic
- Ginseng Biological Effects and Applications
- Cholesterol and Lipid Metabolism
- Parkinson's Disease Mechanisms and Treatments
- Phytoestrogen effects and research
- Neutropenia and Cancer Infections
- Click Chemistry and Applications
- Hedgehog Signaling Pathway Studies
- Traditional Chinese Medicine Analysis
- Nerve injury and regeneration
- Neurotransmitter Receptor Influence on Behavior
Florida College
2023-2024
University of Florida
2021-2024
Thermo Fisher Scientific (United States)
2023-2024
First Affiliated Hospital of Gannan Medical University
2024
Kunming Medical University
2016-2020
Prince of Songkla University
2013-2015
Beijing University of Posts and Telecommunications
2013
Dongguk University
2010
Chinese Academy of Sciences
2007-2008
Abstract Regulatory T cells (Tregs) play an important role in maintaining immune homeostasis and, within tumors, their upregulation is common and promotes immunosuppressive microenvironment. Therapeutic strategies that can eliminate Tregs the tumor (i.e., therapies do not run risk of affecting normal tissues), are urgently needed for development cancer immunotherapies. Here we report our discovery B-cell lymphoma extra-large (BCL-X L ) as a potential molecular target tumor-infiltrating (TI)...
An effective cancer therapy requires killing cells and targeting the tumor microenvironment (TME). Searching for molecules critical multiple cell types in TME, we identified NR4A1 as one such molecule that can maintain immune suppressive TME. Here, establish a valid target immunotherapy describe first-of-its-kind proteolysis-targeting chimera (PROTAC, named NR-V04) against NR4A1. NR-V04 degrades within hours vitro exhibits long-lasting degradation tumors with an excellent safety profile....
The present study evaluated the topical anti-inflammatory potential of a standardized pomegranate rind extracts (SPRE) in parallel with its marker compound ellagic acid (EA, 13% w/w) against mouse model contact dermatitis. In phenol-induced ear edema, application SPRE (5, 2.5, and 1 mg/ear) EA (0.65, 0.325, 0.13 mg/ear, equivalent to content SPRE) dose-dependently reduced edema maximal inhibition 79.12% 73.63%, respectively. Triamcinolone (0.1 diclofenac (1 as reference drugs inhibited by...
Abstract Background Neuropathic pain (NP) is a chronic pathological that affects the quality of life and huge medical burden for affected patients. In this study, we aimed to explore effects secreted phosphoprotein 1 (SPP1) on NP. Methods We established constriction injury (CCI) rat model, knocked down SPP1 via an intrathecal injection, and/or activated extracellular signal‐regulated kinase (ERK) pathway with insulin‐like growth factor (IGF‐1) treatment. Pain behaviors, including paw...
The mismatch repair (MMR) pathway is known as a tumor suppressive and genes involved in MMR are commonly mutated hereditary colorectal or other cancer types. However, the function of genes/proteins breast progression metastasis largely unknown. We found that MSH2, but not MLH1, highly enriched basal-like (BLBC) its protein expression inversely correlated with overall survival time (OS). MSH2 frequently elevated due to genomic amplification gain-of-expression BLBC, which results increased...
Certificateless short signature schemes can not only have the advantage of certificateless signature, but also provide a size in communication. However, all existing proven secure against normal adversary which obtain valid for original public key rather than super replaced key. Recently, Fan et al. proposed scheme is very efficient, we found it still cannot adversary. In this paper, first analysis their scheme, and then present an improved adversaries. Furthermore, our both strongest...
Abstract An effective cancer therapy requires both killing cells and targeting tumor-promoting pathways or cell populations within the tumor microenvironment (TME). We purposely search for molecules that are critical multiple types in TME identified nuclear receptor subfamily 4 group A member 1 (NR4A1) as one such molecule. NR4A1 has been shown to promote aggressiveness of maintain immune suppressive TME. Using genetic pharmacological approaches, we establish a valid therapeutic target...
Abstract B-cell lymphoma X-large (BCL-XL) emerges as a significant player in cancer progression. In our recent findings, we unveil the efficacy of proteolysis-targeting chimeras (PROTACs) directed against BCL-XL, demonstrating their capacity to not only eliminate cells but also target tumor-induced regulatory T (TI-Tregs). Notably, BCL-XL's role promoting breast metastasis extends beyond its anti-apoptotic function. We posit that BCL-XL-targeting PROTACs (BCL-XL-Ps) hold promise for treating...
Abstract The mismatch repair (MMR) pathway is known as a tumor suppressive and genes involved in MMR are commonly mutated hereditary colorectal or other cancer types. However, the function of genes/proteins breast progression metastasis largely unknown. We found that MSH2, but not MLH1, highly enriched basal-like (BLBC) its protein expression inversely correlated with overall survival time (OS). MSH2 frequently elevated due to genomic amplification gain-of-expression BLBC, which results...
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Abstract Interleukin 2 (IL-2) is the first identified cytokine and its interaction with receptors has been known to shape immune responses in many lymphoid or non-lymphoid tissues for more than four decades. Active T cells are primary cellular source IL-2 production epithelial have never considered major of under physiological conditions. It is, however, tempting speculate that could potentially express regulates intricate interactions between lymphocytes. Datamining our recently published...
Certificateless short signature can not only have the advantage of certificateless signature, but also provide a size in communication.However , all existing scheme proven secure against normal adversary which obtain valid signatures for original public key rather than super replaced key.In order to solve problem, so this paper, we proposed an efficient and provably be proved that it is adversaries random oracle model under computational Diffie-Hellman (CDH) assumption.Furthermore, our both...
13-Chlorine-3,15-dioxy-gibberellic acid methyl ester (GA-13315) is a gibberellin derivative that exhibits selective cytotoxicity to multidrug resistant MCF-7/ADR cells and reverses drug resistance when administered at subtoxic doses in combination with chemotherapy drugs. The present study aimed investigate the impact of chronic GA-13315 exposure on chemosensitivity MCF-7 HCT116 cell lines. Cells were dose 1 µM for 12 weeks sensitivity GA-13315, irinotecan cisplatin, was assessed. Cell...
Abstract B-cell lymphoma X-large (BCL-XL) is a member of the BCL-2 protein family and has been known as an anti-apoptotic protein. As viable target for cancer therapy, we recently found that proteolysis-targeting chimeras (PROTAC, currently under phase I clinical investigation) against BCL-XL kill cells well tumor-induced regulatory T (TI-Tregs). Interestingly, shown to promote breast metastasis via function independent its function. We reason BCL-XL-targeting PROTACs can be potentially used...