A5101588419- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Photosynthetic Processes and Mechanisms
- Plant Molecular Biology Research
- Metabolism, Diabetes, and Cancer
- Cancer, Lipids, and Metabolism
- Bone health and treatments
- Electrochemical sensors and biosensors
- Molecular Sensors and Ion Detection
- Plant Gene Expression Analysis
- Advanced biosensing and bioanalysis techniques
- Bone Metabolism and Diseases
- Phase Change Materials Research
- Polymer composites and self-healing
- Diabetes Treatment and Management
- RNA regulation and disease
- Global trade and economics
- CRISPR and Genetic Engineering
- NF-κB Signaling Pathways
- Circular RNAs in diseases
- Synthesis and properties of polymers
- Thermal properties of materials
- Hedgehog Signaling Pathway Studies
- Advanced Sensor and Energy Harvesting Materials
- Plant nutrient uptake and metabolism
Beijing University of Chemical Technology
2023-2025
Ministry of Education
2025
Xiamen University
2024
Shanghai Municipal Center For Disease Control Prevention
2024
Nanjing Agricultural University
2016-2024
Fujian Agriculture and Forestry University
2017-2024
Hefei University of Technology
2022-2023
National Chung Cheng University
2022
Guangdong Medical College
2020-2021
Henan University Huaihe Hospital and Huaihe Clinical Institute
2019-2020
Hedgehog-regulated processing of the transcription factor cubitus interruptus (Ci) in Drosophila depends on phosphorylation C-terminal region Ci by cAMP-dependent protein kinase and subsequently casein 1 glycogen synthase 3. also requires Slimb, an F-box SCF ( S kp1/ C ullin/ F -box proteins) complex, proteasome, but interplay between activity Slimb proteasome remains unclear. Here we show that Gli3 protein, a homolog Ci, set four sites primes subsequent adjacent Our gain- loss-of-function...
Calcium/calmodulin-dependent protein kinase (CCaMK) has been shown to play an important role in abscisic acid (ABA)-induced antioxidant defense and enhance the tolerance of plants drought stress. However, its downstream molecular events are poorly understood. Here, we identify a NAC transcription factor, ZmNAC84, maize (Zea mays), which physically interacts with ZmCCaMK vitro vivo. ZmNAC84 displays partially overlapping expression pattern after ABA treatment, H2O2 is required for ABA-induced...
OBJECTIVE Diabetes presenting at a younger age has more aggressive nature. We aimed to explore the association of type 2 diabetes mellitus (T2DM) diagnosis with subsequent cancer incidence in large Chinese population. RESEARCH DESIGN AND METHODS The prospective population-based longitudinal cohort included 428,568 newly diagnosed T2DM patients from 2011 2018. Participants were divided into six groups according their diagnosis: 20–54, 55–59, 60–64, 65–69, 70–74, and ≥75 years. overall 14...
Cytokines, including receptor activator of nuclear factor κB ligand (RANKL) and TNF, induce increased osteoclast (OC) formation bone loss in postmenopausal osteoporosis inflammatory arthritides. RANKL TNF can independently OC vitro from WT precursors via receptor-associated (TRAF) adaptor proteins, which bind to their receptors. Of these, only TRAF6 is required for RANKL-induced osteoclastogenesis vitro. However, the molecular mechanisms involved remain incompletely understood. Here we...
ABSTRACT RelA-mediated NF-κB canonical signaling promotes mesenchymal progenitor cell (MPC) proliferation, but inhibits differentiation of mature osteoblasts (OBs) and thus negatively regulates bone formation. Previous studies suggest that RelB may also regulate formation through noncanonical signaling, they involved a complex knockout mouse model, the molecular mechanisms were not investigated. Here, we report RelB−/− mice develop age-related increased trabecular mass associated with marrow...
Ag+ and Zn2+ have already been used in combinations to obtain both enhanced antibacterial effect low cytotoxicity. Despite this, it is still unclear how the co-works with synergistic activity. The main purposes of this study were investigate co-work pattern optimum ratio between their activity against E. faecalis, possible mechanisms behind synergy primary application Ag+-Zn2+ faecalis biofilm on dentin. A serial atomic combination ratios tested planktonic biofilm-resident dentin, efficiency...
Papillary thyroid carcinoma (PTC) is the most common type of cancer. Elucidating molecular network that altered in PTC may lead to identification critical insight into pathogenesis PTC. Thus far, little known regarding global metabolomic alterations Gas chromatography coupled with mass spectrometry‑based metabolomics was used analyze matched and normal tissues obtained from patients. Multivariate statistical analyses were employed determine significant differences. The mRNA levels associated...
TNF induces bone loss in common diseases by promoting osteoclast formation directly and indirectly, but it also limits inducing expression of NF-κB p100. Osteoclast precursors (OCPs) are derived from M1 (inflammatory) M2 (resident) macrophages. However, is not known if stimulates or through regulation differentiation RelB, a partner p100, involved. To investigate these questions, we treated marrow cells (BMCs) with M-CSF alone combination to enrich for OCPs, which called M-OCPs T-OCPs,...
Flexible polymeric solid–solid phase change materials (PCMs) have garnered continuous attention owing to their potential for thermal management in flexible/wearable devices and non-leakage characteristics. However, it is still a big challenge obtain PCMs with both flexibility high latent heat. In this study, bottlebrush polysiloxane networks alkyl side chains of different lengths (Si-X) are prepared through one-step grafting cross-linking process. The influence the length chain on mechanical...
A novel lanthanide coordination polymer nanoparticle (LCPN)-based ternary complex was synthesized via the self-assembly of a terbium ion (Tb(3+)) with nucleotide (GMP) and mercury (Hg(2+)) in aqueous solution. The as-prepared LCPN-based (Tb-GMP-Hg) can be applied to development time-resolved luminescence assays oxidase-based biosensors.
Cross talking between natural senescence and cell death in response to pathogen attack is an interesting topic; however, its action mechanism kept open. In this study, 33 OsWRKY genes were obtained by screening with leaf aging procedure through RNA-seq dataset, 11 of them confirmed a significant altered expression level the flag leaves during using reverse transcript quantitative PCR (RT-qPCR). Among them, OsWRKY2 , OsWRKY14 OsWRKY26 OsWRKY69 OsWRKY93 members exhibited short-term alteration...
Papillary thyroid carcinoma (PTC) is the most common cancer. Nuclear magnetic resonance (NMR)‑based metabolomic technique gold standard in metabolite structural elucidation, and can provide different coverage of information compared with other techniques. Here, we firstly conducted NMR based metabolomics study regarding detailed metabolic changes especially pathway related to PTC pathogenesis. 1H NMR-based was adopted conju-nction multivariate analysis analyze matched tumor normal tissues...
Coordination of gene expression in mitochondria, plastids, and nucleus is critical for plant development survival. Although WHIRLY2 (WHY2) involved mitochondrial genome repair affects the DNA copy number genome, detailed mechanism action WHY2 protein still elusive. In this study, we found that was triple-localized among during Arabidopsis (
Flag leaf senescence is an important biological process that drives the remobilization of nutrients to growing organs rice. Leaf controlled by genetic information via gene expression and histone modification, but precise mechanism as yet unclear. Here, we analysed genome-wide acetylated lysine residue 9 H3 (H3K9ac) enrichment chromatin immunoprecipitation-sequencing (ChIP-seq), examined its association with transcriptomes RNA-seq during flag aging in rice (Oryza sativa). We found H3K9...
The prevalence of drug-resistant Mycobacterium tuberculosis (Mtb) strains makes disease control more complicated, which is the main cause death in (TB) patients.Early detection and timely standard treatment are key to current prevention TB.In recent years, despite continuous advancement TB diagnostic technology, needs for clinical rapid accurate diagnosis still not fully met.With development sequencing research human microecology has been intensified.This study aims use 16 rRNA technology...
Multiple organellar RNA editing factor (MORF) complex was shown to be highly associated with C-to-U of vascular plant editosome. However, mechanisms by which MORF9-dependent plastid controls development and responses environmental alteration remain obscure. In this study, we found that loss MORF9 function impaired PSII efficiency, NDH activity, carbohydrate production, rapidly promoted nuclear gene expression including sucrose transporter sugar/energy responsive genes, attenuated root growth...
In this work, a label-free molecular beacon (MB)-like biosensor is designed for the determination of H<sub>2</sub>O<sub>2</sub> and glucose based on fluorescence regulation Hoechst dyes hosted by AT-rich single-stranded DNA (ssDNA), in which Hg<sup>2+</sup> cysteine (Cys) act as activators.
Background: Circular RNAs (circRNAs) are significant molecular targets in various types of human cancers. The functional mechanism circRNA_0025033 (circ_0025033) ovarian cancer (OC) was discussed the current report. Methods: quantitative real-time polymerase chain reaction (qRT-PCR) used for determining circ_0025033 and microRNA-330-5p (miR-330-5p) levels. Cell Counting Kit-8 (CCK-8) transwell assays were separately exploited to analyze cell viability migration/invasion. apoptosis assessed...