Calcium silicate (CaSiO3, CS) ceramics have received significant attention for application in bone regeneration due to their excellent vitro apatite-mineralization ability; however, how prepare porous CS scaffolds with a controllable pore structure tissue engineering still remains challenge. Conventional methods could not efficiently control the and mechanical strength of scaffolds, resulting unstable vivo osteogenesis. The aim this study is set out solve these problems by applying modified...

Controllable drug delivery is one of the important ways for therapy bone cancer. Conventional mesoporous silica nano-particles may lack dual properties combining controllable anti-cancer drugs and bone-forming bioactivity cancer therapy. The aim this study to synthesize bioactive glass (MBG) nanospheres with combined functions controlled delivery, further investigate their property as well functional effect on bone-cancer cells. MBG spherical morphology internal microstructures were...

Porous SiO2 scaffolds with mesopore structure (named as MS scaffolds) have been proposed suitable for bone tissue engineering due to their excellent drug-delivery ability; however, the mineralization and cytocompatibility of are far from optimal engineering, it is also unclear how delivery drugs affects osteoblastic cells. The aims present study were improve by coating mussel-inspired polydopamine on pore walls scaffolds. effects modification investigated respect apatite attachment,...

Bioactive materials are playing an important role in sealing apical root canals of teeth, inducing bone/cementum tissue regeneration and inhibiting bacterial viability. Conventional Ca(OH)2 have limitations for filling teeth due to their low mineralization ability potential cytotoxicity. The aim this study is prepare bioactive mesoporous calcium–silicate (MCS) nanoparticles the application canal a tooth. structure, specific surface area, pore volume morphology MCS particles were...

Abstract Aim To evaluate the effect of instrumentation using Reciproc Blue ( RB ; VDW , Munich, Germany) and XP ‐endo Shaper ‐S; FKG Dentaire, La Chaux‐deFonds, Switzerland) systems on area untouched canal wall AUCW ), accumulated hard‐tissue debris AHTD ) efficacy three irrigation protocols percentage reductions (red%) within C‐shaped canals mandibular molars. Methodology Seventy molars with were scanned, matched assigned to two shaping groups n = 35): ‐S. Following instrumentation,...

Abstract Background Z-DNA binding protein 1 (ZBP1) is a vital innate immune sensor that regulates inflammation during pathogen invasion. ZBP1 may contribute to pyroptosis, apoptosis and necroptosis in infectious diseases. In this study, Fusobacterium nucleatum ( F. ) infection caused periapical through proinflammatory cell death was involved regulating the inflammatory activities by apical periodontitis (AP). Methods Human tissues were tested fluorescent situ hybridization,...

Abstract Strontium (Sr), Zinc (Zn), magnesium (Mg), and silicon (Si) are reported to be essential trace elements for the growth mineralization of bone. We speculated that combination these bioactive in bioceramics may effective regulate osteogenic property bone‐forming cells. In this study, two Sr‐containing silicate bioceramics, Sr 2 ZnSi O 7 (SZS) MgSi (SMS), were prepared. The biological response human bone marrow mesenchymal stem cells (BMSCs) (in forms powders dense ceramic bulks) was...

Ag+ and Zn2+ have already been used in combinations to obtain both enhanced antibacterial effect low cytotoxicity. Despite this, it is still unclear how the co-works with synergistic activity. The main purposes of this study were investigate co-work pattern optimum ratio between their activity against E. faecalis, possible mechanisms behind synergy primary application Ag+-Zn2+ faecalis biofilm on dentin. A serial atomic combination ratios tested planktonic biofilm-resident dentin, efficiency...

Effects of adsorbed and templated nanosilver in mesoporous calcium-silicate nanoparticles on inhibition bacteria colonization dentin Wei Fan,1,* Daming Wu,1,* Franklin R Tay,2 Tengjiao Ma,1 Yujie Wu,1 Bing Fan1 1The State Key Laboratory Breeding Base Basic Science Stomatology (Hubei-MOST) Oral Biomedicine Ministry Education, School Hospital Stomatology, Wuhan University, Wuhan, People's Republic China; 2Department Endodontics, Georgia Regents Augusta, Georgia, USA *These authors contributed...

Removing infectious bacteria biofilms from the root canal system is crucial for a successful endodontic treatment. This study investigated antibacterial effect of femtosecond laser (fs-laser) against Enterococcus faecalis (E. faecalis) and Fusobacterium nucleatum (F. nucleatum) on dentin. The chemical composition dentin slices extracted human teeth was analyzed using FTIR Raman probes. morphology fs-laser ablated grooves evaluated by an optical profiler, ablation fluence threshold obtained...

Abstract The apical delta is an intricate system within the root canal and incompletely debridement may affect long-term prognosis of therapy. aim present study to investigate morphologic features deltas in human teeth with micro-computed tomography (micro-CT) using a centreline-fitting algorithm. One hundred thirty-six were detected 1400 teeth. Molars had more (15.8%) than anterior (6.3%). In maxillary molars, mesiobuccal significantly higher prevalence palatal or distobuccal root. median...

In infected periapical tissues, Enterococcus faecalis is one of the most common dominant bacteria. Chlorhexidine has been proved to show strong antibacterial ability against E. but ineffective in promoting mineralization for tissues around root apex. Mesoporous calcium-silicate nanoparticles are newly synthesized biomaterials with excellent promote and carry-release bioactive molecules a controlled manner. this study, mesoporous were functionalized chlorhexidine their releasing profile,...

The prevention and treatment of oral diseases is more difficult in diabetic patients with poorly controlled blood glucose levels. This study aims to explore an effective, low-cytotoxicity medication for root canal patients. antibacterial effect the combination Triton X-100 (TX-100) metformin (Met) on Enterococcus faecalis (E. faecalis) was evaluated by determining minimum inhibitory concentration (MIC), bactericidal required kill 99% bacteria (MBC99) conducting dynamic time-killing assays....