A5031366454- Genetic Associations and Epidemiology
- Liver Disease Diagnosis and Treatment
- Gout, Hyperuricemia, Uric Acid
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Bioinformatics and Genomic Networks
- Gut microbiota and health
- Folate and B Vitamins Research
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Cancer, Lipids, and Metabolism
- Cardiovascular Disease and Adiposity
- RNA modifications and cancer
- Dietary Effects on Health
- Colorectal Cancer Screening and Detection
- Nutritional Studies and Diet
- Biochemical Analysis and Sensing Techniques
- Genetics, Aging, and Longevity in Model Organisms
- Alcohol Consumption and Health Effects
- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
- Physical Activity and Health
- Cardiovascular Health and Risk Factors
- Pharmacology and Obesity Treatment
- Cancer-related molecular mechanisms research
Ruijin Hospital
2021-2025
Shanghai Jiao Tong University
2022-2025
Princess Margaret Cancer Centre
2024-2025
University Health Network
2024-2025
University of Toronto
2024-2025
University of Bristol
2022
Shanghai Institute of Hematology
2022
Institut des Maladies Métaboliques et Cardiovasculaires
2022
We investigated the causal relationships between gut microbiota (GM), stroke, and potential metabolite mediators using Mendelian randomization (MR).We leveraged summary statistics of GM (n=18,340 in MiBioGen consortium), blood metabolites (n=115,078 UK Biobank), stroke (cases n=60,176 controls n=1,310,725 Global Biobank Meta-Analysis Initiative) from largest genome-wide association studies to date. performed bidirectional MR analyses explore two mediation analyses, two-step multivariable MR,...
GrimAge acceleration (GrimAgeAccel) and PhenoAge (PhenoAgeAccel) are DNA methylation-based markers of accelerated biological aging, standing out in predicting mortality age-related cardiometabolic morbidities. Causal risk factors for GrimAgeAccel PhenoAgeAccel unclear. In this study, we performed 2-sample univariable multivariable Mendelian randomization (MR) to investigate causal associations 19 modifiable socioeconomic, lifestyle, with PhenoAgeAccel. Instrument variants representing were...
OBJECTIVE Diabetes presenting at a younger age has more aggressive nature. We aimed to explore the association of type 2 diabetes mellitus (T2DM) diagnosis with subsequent cancer incidence in large Chinese population. RESEARCH DESIGN AND METHODS The prospective population-based longitudinal cohort included 428,568 newly diagnosed T2DM patients from 2011 2018. Participants were divided into six groups according their diagnosis: 20–54, 55–59, 60–64, 65–69, 70–74, and ≥75 years. overall 14...
Objectives Our aim was to investigate the interactive causal effects between gut microbiota and host urate metabolism explore underlying mechanism using genetic methods. Methods We extracted summary statistics from abundance of 211 taxa MiBioGen (N =18,340), 205 pathways Dutch Microbiome Project =7738), gout Global Biobank Meta-analysis Initiative =1,448,128), CKDGen =288,649), replication datasets Urate Genetics Consortium =69,374; N =110,347). used linkage disequilibrium score regression...
Abstract Background Gut microbiota imbalances have been suggested as a contributing factor to atrial fibrillation (AF), but the causal relationship is not fully understood. Objectives To explore relationships between gut and AF using Mendelian randomization (MR) analysis. Methods Summary statistics were from genome-wide association studies (GWAS) of 207 microbial taxa (5 phyla, 10 classes, 13 orders, 26 families, 48 genera, 105 species) (the Dutch Microbiome Project) two large meta-GWASs AF....
OBJECTIVE We aimed to examine the effects of a 5:2 diet (2 days per week energy restriction by formula diet) or an exercise high-intensity interval training and resistance training) intervention compared with routine lifestyle education (control) on glycemic control cardiometabolic health among adults overweight/obesity type 2 diabetes. RESEARCH DESIGN AND METHODS This two-center, open-label, three-arm, parallel-group, randomized controlled trial recruited 326 participants diabetes them into...
The pathogenesis of idiopathic pulmonary fibrosis (IPF) remains unclear; previous studies revealed the underlying connection between IPF and diabetes, but there is no consensual opinion. This study aimed at examining association Type 1 diabetes (T1D) using Mendelian randomization (MR). In our two-sample MR study, we selected single nucleotide polymorphisms (SNPs) that are strongly associated with T1D in a genome-wide (GWAS) from IEU (dataset: ebi-a-GCST005536) obtained their corresponding...
ABSTRACT Identifying factors affecting lifespan, including genes or proteins, enables effective interventions. We prioritized potential drug targets and provided insights into biological pathways for healthy longevity by integrating Mendelian randomization, cohort, experimental studies. identified causal effects of tissue‐specific genetic transcripts serum protein levels on three outcomes: the parental top 1% 10% extreme longevity, utilizing randomization multi‐traits colocalization,...
Abstract Objective: HPV-positive and HPV-negative head neck squamous cell carcinoma (HNSCC) are distinct entities from an epidemiological biological standpoint. We aimed to evaluate the predictive performance of polygenic risk scores (PRS), which could be a surrogate when behavioral data missing or deemed unreliable, for tobacco smoking (Smoking Initiation [SI], Age Smoking Initiation, Cigarettes Per Day [CPD], Cessation) alcohol consumption (Drinks Week [DPW]) their impact on HNSCC...
ABSTRACT This study aims to evaluate the causal effect of sodium-glucose cotransporter 2 (SGLT2) inhibition on bone mineral density (BMD), osteoporosis, and fracture risk using genetics. Two-sample Mendelian randomization (MR) analyses were performed utilizing two sets genetic variants as instruments (six single-nucleotide polymorphisms [SNPs]) associated with SLC5A2 gene expression glycated hemoglobin A1c levels. Summary statistics BMD from Genetic Factors for Osteoporosis consortium (BMD...
Atrial fibrillation (AF) is an age-related disease, while telomeres play a central role in aging. But the relationship between AF and telomere length (LTL) still controversial. This study aims to examine potential causal association LTL by using Mendelian randomization (MR).Bidirectional two-sample MR, expression protein quantitative trait loci (eQTL pQTL)-based MR were performed genetic variants from United Kingdom Biobank, FinnGen, meta-analysis study, which comprised nearly 1 million...
The association between the gut microbiota and thyroid cancer remains controversial.We aimed to systematically investigate interactive causal relationships abundance metabolism pathways of cancer.We leveraged genome-wide studies for 211 taxa from MiBioGen study (N = 18 340), 205 Dutch Microbiome Project 7738), Global Biobank Meta-analysis Initiative cases 6699 N participants 1 620 354). We performed a bidirectional Mendelian randomization (MR) causality vice versa. systematic review previous...
Abstract Aim To determine the association of presence diabetes and, among persons with diabetes, age at type 2 mellitus (T2DM) onset, BMI and interactive effect subsequent thyroid cancer risk. Materials Methods We conducted a population register‐based longitudinal cohort study in Shanghai, including 428 568 new‐onset T2DM matched general population. The risk subgroups was calculated based on standardized incidence ratio (SIR), hazard (HR) Cox proportional hazards models. Results In total,...
Abstract Context The effect of lowering systolic blood pressure (SBP) on clinical outcomes in diabetic patients is controversial. Objective We used 2-sample mendelian randomization (MR) to study the causal decreasing SBP risk macrovascular and microvascular patients. Methods 362 SBP-related genetic variants from a large genome-wide association (n = 299 024) UK Biobank 375 256) as exposure. evaluated 5 complications up 60 742 cases diabetes, including coronary artery disease (CAD), peripheral...
Quarantine due to the COVID-19 pandemic may have created great psychological stress among vulnerable populations. We aimed investigate prevalence of anxiety and explore association between physical activities (PA) risk in people with non-communicable diseases during period lockdown.We conducted a cross-sectional telephone survey from February 25 April 20, 2020, lockdown Shanghai. Up 8000 patients type 2 diabetes and/or hypertension were selected using multi-stage cluster random sampling. PA...
Abstract Background This study aimed to investigate the risks of all-cause and cardiovascular mortality associated with blood pressure (BP) levels 130–139/80–89 mmHg in Chinese adults different glucose metabolism, during a long-term follow-up over 20 years. Methods A prospective population-based cohort 2,132 Shanghai was established 2002 followed for 21 The association between BP categories assessed, risk further analyzed using multiple Cox regression analysis by combining categories....
Aim We aimed to detect the individual and combined effect of glucose metabolic components on cognitive function in particular domains among older adults. Methods Data 2,925 adults aged over 60 years from 2011 2014 National Health Nutrition Examination Survey were analyzed. Individuals’ was evaluated using Digit Symbol Substitution Test (DSST), Animal Fluency (AF), Consortium Establish a Registry for Alzheimer’s Disease Immediate Recall (CERAD-IR), CERAD Delayed (CERAD-DR). Participants’...
<p dir="ltr"><a href="" target="_blank"><b>Objective</b></a></p><p dir="ltr">We aimed to examine the effects of “5:2 regimens” diet (2-day/week energy restriction by formula diet) or exercise high-intensity interval training and resistance training) intervention compared with routine lifestyle education (control) on glycemic control cardiometabolic health among adults overweight/obesity type 2 diabetes.</p><p dir="ltr"><b>Research...
Abstract Aim To evaluate the effect of metformin on urate metabolism. Materials and Methods Using UK Biobank, we first performed association analyses use with levels, risk hyperuricaemia incident gout in patients diabetes. explore causal gout, identified genetic variants proxying glycated haemoglobin (HbA1c)‐lowering targets conducted a two‐sample Mendelian randomization (MR) utilizing summary‐level data from CKDGen (n = 288 649) FinnGen cohort. We two‐step MR to mediation body mass index...
The study aimed to explore the associations of nonalcoholic fatty liver disease (NAFLD) with remission and progression along glycemic continuum.