A5101732507- MicroRNA in disease regulation
- Heme Oxygenase-1 and Carbon Monoxide
- Ginseng Biological Effects and Applications
- Cancer-related molecular mechanisms research
- Nuclear Structure and Function
- Membrane-based Ion Separation Techniques
- Retinoids in leukemia and cellular processes
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- Peroxisome Proliferator-Activated Receptors
- Cardiac Fibrosis and Remodeling
- Acute Myeloid Leukemia Research
- Cardiac Arrest and Resuscitation
- Tryptophan and brain disorders
- Angiogenesis and VEGF in Cancer
- Virus-based gene therapy research
- Machine Learning and ELM
- Hydrogels: synthesis, properties, applications
- Congenital heart defects research
- Mesenchymal stem cell research
- Cancer Mechanisms and Therapy
- FOXO transcription factor regulation
- Metabolism, Diabetes, and Cancer
- Neonatal Health and Biochemistry
- Extracellular vesicles in disease
Guilin Medical University
2021-2024
Fourth People's Hospital of Sichuan Province
2023
University of Electronic Science and Technology of China
2023
University of Toledo
2015-2022
Zhejiang Provincial People's Hospital
2020-2022
Hangzhou Medical College
2020-2022
Bengbu Medical College
2021
Anyang Institute of Technology
2018-2019
Kunming Medical University
2018-2019
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2019
Chronic kidney disease (CKD) is accompanied by cardiac fibrosis, hypertrophy, and dysfunction, which are commonly referred to as uremic cardiomyopathy. Our previous studies found that Na/K-ATPase ligands or 5/6th partial nephrectomy (PNx) induces fibrosis in rats mice. The current study used vitro vivo models explore novel roles for microRNA this mechanism of formation. To accomplish this, we performed profiling with RT-qPCR based arrays on tissue from subjected marinobufagenin (MBG)...
The Na/K-ATPase is an important membrane ion transporter and a signaling receptor that essential for maintaining normal cell function. current study examined the role of in regulating miR-29b-3p, anti-fibrotic microRNA, mouse chronic kidney disease (CKD) model (5/6th partial nephrectomy or PNx). results showed CKD induced significant reduction miR-29b-3p expression heart tissue by activation Src NFκB these animals. To demonstrate signaling, we also performed PNx surgery on α1 heterozygous...
Chinese chinquapin (Castanea henryi) nut provides a rich source of starch and nutrients as food feed, but its yield is restricted by low ratio female to male flowers. Little known about the developmental programs underlying sex differentiation To investigate involvement phytohormones during differentiation, we described morphology floral organs cytology flower analyzed endogenous levels indole-3-acetic acid (IAA), gibberellins (GAs), cytokinins (CKs), abscisic (ABA) in flowers, investigated...
T-LAK cell-originated protein kinase (TOPK), a serine/threonine kinase, is highly expressed in variety of tumors and associated with poor prognosis human malignancies. However, the activation mechanism TOPK still unrevealed. Herein, first we found that Src directly bound phosphorylated at Y74 Y272 vitro. Anti-phospho-TOPK was prepared, endogenous phosphorylation detected colon cancer cells, inhibited cells expressing low levels Src. Subsequently, stably transfected double mutated (TOPK-FF)...
Diabetes is a risk factor for myocardial infarction, and outcomes after infarction are worse among diabetics compared with nondiabetics. associated impaired Heme clearance. Here, we determined whether heme toxicity clearance contribute to diabetic injury assessed IL-10 as therapeutic agent infarction. Plasma-free hemoglobin was significantly elevated in mice nondiabetic Infarct size had strong correlation the level of plasma-free hemoglobin. Hemoglobin reactive iron deposition within infarct...
Acute kidney injury (AKI) is a common complication after myocardial infarction (MI) and associated with significant morbidity mortality. AKI MI occurs more frequently in patients diabetes, however, the underlying mechanisms are poorly understood, specific treatments lacking. Using murine model, we show that diabetic mice had higher expression of marker, neutrophil gelatinase-associated lipocalin (NGAL), 3 days compared control mice. This NGAL was still controlling for differences infarct...
// Dan Wu 1, 2, * , Ping Yuan Changshu Ke 3 Hua Xiong Jingwen Chen 1 Jinguang Guo Mingmin Lu Yanyan Ding 2 Xiaoming Fan Qiuhong Duan Fei Shi Feng Zhu Department of Dermatology the General Hospital Air Force, Beijing, 100142, PR China Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University Science Technology, Wuhan, Hubei, 430030, Pathology, Hospital, These authors have contributed equally to this work Correspondence to: Duan, e-mail: duanqhwz@hust.edu.cn Shi,...
The behavioral and neuroendocrine reactivity to a novel environment (open field) the adrenocorticotropic hormone (ACTH)/corticosterone response corticotropin-releasing factor (CRF) challenge were measured in 2-mo-old rats from four inbred strains derived Wistar-Kyoto rat: spontaneously hypertensive (SHRs), behaviorally hyperactive novelty; WKY, neither nor hyperactive; WKHA, but normotensive; WKHT, only hypertensive. ACTH CRF was much lower SHRs than WKYs, this reduced being clearly...
Tissue fibrosis is a significant health issue associated with organ dysfunction and failure. Increased deposition of collagen other extracellular matrix (ECM) proteins in the interstitial area major process tissue fibrosis. The microRNA-29 (miR-29) family has been demonstrated as anti-fibrotic microRNAs. Our recent work showed that dysregulation miR-29 contributes to formation cardiac animal models uremic cardiomyopathy, whereas replenishing attenuated these animals. However, excessive...
SLC41A3 is a member of the solute carrier family 41 (SLC41) and involved in many cellular processes as magnesium ion transporter. Although it plays an important role cancer formation development, correlation between expression occurrence prognosis hepatocellular carcinoma (HCC) remains unclear. Therefore, this study was focused on evaluation relationship development HCC.Firstly, we collected mRNA HCC through platform Oncomine. Then, subgroups were performed by UALCAN website analyzed...
Cardiac progenitor cells including c-kit(+) and cardiosphere-derived (CDCs) play important roles in cardiac repair regeneration. CDCs were reported to contain only small subpopulations of recent publications suggested that depletion the subpopulation has no effect on regenerative properties CDCs. However, our current study showed vast majority from murine heart actually express c-kit, albeit, an intracellular non-glycosylated form. Immunostaining flow cytometry fluorescent signal indicative...
Cognitive impairment is a common manifestation in patients with T2DM mellitus (T2DM). Ginsenoside Rg1 (GRg1) the main active substance extracted from ginseng or Panax notoginseng. was induced by feeding rats high-sugar and high-fat diet combined low-dose intraperitoneal injection of streptozotocin (STZ, 35 mg/kg) on an empty stomach. Subsequently, different concentrations GRg1 (25, 50, 100 mg/kg/d) were used to intervene for 8 weeks explore its therapeutic effects potential mechanisms...
Non-coding RNAs are important regulators of protein-coding genes. The current study characterized an antisense long non-coding RNA, ATP1A1-AS1, which is located on the opposite strand Na/K-ATPase α1 gene. Our results show that four splice variants expressed in human adult kidney cells (HK2 cells) and embryonic (HEK293 cells). These can be detected both cytosol nuclear fractions. We also found inhibition DNA methylation has a differential effect expression ATP1A1-AS1 its sense To investigate...
Objective: Myocardial infarction (MI) and subsequent heart failure is a leading cause of death in high or middle income countries. Development treatments that stimulate tissue regeneration revascularization/angiogenesis important to improve the prognosis these patients. Our recent work demonstrated endothelial cell growth supplement (ECGS)-containing medium stimulates differentiation c-kit positive cardiac progenitor cells vitro. The objective current was test whether ECGS can activate...
Figure 1.Peripheral blood and bone marrow smears taken from a patient with ZBTB16-RARA acute promyelocytic leukemia.Large distinctive round promyelocyte cells nuclei were observed in the peripheral (A) (B) (magnification: 1000 x , Wright-Giemsa staining).