A5100654052- Insect Resistance and Genetics
- Ubiquitin and proteasome pathways
- Insect and Pesticide Research
- Machine Learning in Bioinformatics
- Oral microbiology and periodontitis research
- Cancer-related gene regulation
- Fractal and DNA sequence analysis
- Acute Myeloid Leukemia Research
- Connexins and lens biology
- Legionella and Acanthamoeba research
- Retinoids in leukemia and cellular processes
- Nuclear Structure and Function
- Bacterial biofilms and quorum sensing
- Barrier Structure and Function Studies
- Traditional Chinese Medicine Analysis
- Plant tissue culture and regeneration
- Angiogenesis and VEGF in Cancer
- Studies on Chitinases and Chitosanases
- Genomics, phytochemicals, and oxidative stress
- Natural product bioactivities and synthesis
- Wnt/β-catenin signaling in development and cancer
- Escherichia coli research studies
- Epigenetics and DNA Methylation
- Cardiac Fibrosis and Remodeling
- Protease and Inhibitor Mechanisms
Hainan University
2023-2024
Shenzhen University
2023-2024
Hebei University
2021-2024
Sanya University
2024
Jilin University
2024
Southern Medical University Shenzhen Hospital
2023
Southwest University
2017-2021
Anyang Normal University
2020
Virginia Commonwealth University
2016-2017
Shanghai University of Engineering Science
2015
Glycogen synthase kinase-3 β (GSK-3 ), a serine/threonine protein kinase, has been regarded as potential therapeutic target for multiple human cancers. In addition, oxidative stress is closely related to all aspects of cancer. We sought determine the biological function lithium, one kind GSK-3 inhibitors, in process reactive oxygen species (ROS) production colorectal this study, we analyzed cell apoptosis and proliferation by viability, EdU, flow cytometry assays through administration LiCl....
The carmine spider mite Tetranychus cinnabarinus is a major pest of crop and vegetable plants worldwide. Previous studies have shown that scopoletin promising acaricidal compound against cinnabarinus. However, the mechanism remains unclear. In present study, 12 full-length cDNAs chitinase (CHIT) genes from (designated TcCHITs ) were cloned characterized. Although expressed throughout all life stages, their expression levels significantly upregulated during larval nymphal stages....
Biofilms play important roles in microbial communities and are related to infectious diseases. Here, we report direct evidence that a bacterial nox gene encoding NADH oxidase is involved biofilm formation. A dramatic reduction formation was observed Streptococcus sanguinis mutant under anaerobic conditions without any decrease growth. The membrane fluidity of the cells found be decreased fatty acid composition altered, with increased palmitic stearic vaccenic acid. Extracellular DNA reduced...
RNA modification, involving in a wide variety of cellular processes, has been identified over 100 types since 1950s. N6-methyladenosine (m6A), as one the most abundant modifications, is found several species and predominantly located stop codons, long internal exons well 3'UTR. It was reported that m6A modification preferentially appears after G conserved motif RRm6ACH (R = A/G H A/C/U). There are two families enzymes responsible for maintaining balance modification: methyltransferases...
Biofilms are a key component in bacterial communities providing protection and contributing to infectious diseases. However, mechanisms involved S. sanguinis biofilm formation have not been clearly elucidated. Here, we report the identification of novel TetR repressor, brpT (Biofilm Regulatory Protein TetR), formation. Deletion resulted significant increase Interestingly, mutant accumulated more water soluble insoluble glucans its compared wild-type complemented mutant. The mutation led an...
The binding of Shiga-like toxin 1 (Stx1) and 2 (Stx2) to a mucin-like fusion protein, P-selectin glycoprotein ligand-1/mouse IgG2b (PSGL-1/mIgG2b), carrying multiple copies the blood group P1 determinant on O-glycans was investigated with western blot biosensor Biacore. Chinese hamster ovary K-1 (CHO-K1) cells were stably transfected linearized plasmids encoding PSGL-1/mIgG2b pigeon α1,4-galactosyltransferase (α4Gal-T) core β1,6-N-acetylglucosaminyltransferase (C2GnT-I). Western analyses...
Diabetic cardiomyopathy (DCM) is a primary cause of death in diabetic patients; however, its molecular mechanism not yet clear, and there no uniform standard for diagnosis. The aim this study to discover the pathogenesis potential therapeutic targets DCM through screening analysis differentially expressed genes (DEGs) heart ventricles DCM, testify role key hub DCM-induced myocardial dysfunction. Datasets GSE4745 GSE6880 were downloaded from GEO database. difference analysis, visual cluster...
Mango stem-end rot caused by
Background: Hepatocellular carcinoma (HCC) is an aggressive malignancy that poses a serious threat to human life. The conventional therapies for HCC cannot substantially improve overall survival (OS), disease duration, and prognosis. Therefore, it important study the underlying mechanism of seek better methods prevention treatment. Ubiquitination post-translational modification modulates great cellular function by cooperating with E1, E2, E3 ligases. Yet, ubiquitination lysine residues in...
K-mer frequency statistics of biological sequences is a very important and problem in information processing.This paper addresses the index k-mer for large scale data reading DNA limited memory space time.Using hash algorithm to establish index, model set up base pairing, get length statistic quickly, so as avoid searching all index.At same time, program uses table build search model, zipper method resolve conflict case address conflict.Algorithm time complexity analysis experimental results...
Figure 1.Peripheral blood and bone marrow smears taken from a patient with ZBTB16-RARA acute promyelocytic leukemia.Large distinctive round promyelocyte cells nuclei were observed in the peripheral (A) (B) (magnification: 1000 x , Wright-Giemsa staining).
Mango stem-end rot caused by Lasiodiplodia theobromae is a major postharvest disease resulting in considerable loss during storage and transportation China. Prochloraz, demethylation inhibitor, commonly used for control mango orchards storage. However, resistance to prochloraz has been found L. of mango. This study aimed explore the mechanisms responsible using biochemical molecular methods. The results showed that no mutations were LtCYP51 gene resistant strains. higher expression was...