A5101777923- Advanced Fiber Optic Sensors
- Advanced Measurement and Detection Methods
- Advanced Measurement and Metrology Techniques
- Cardiovascular Function and Risk Factors
- Advanced Sensor and Control Systems
- Semiconductor Lasers and Optical Devices
- Cardiac Ischemia and Reperfusion
- Optical Systems and Laser Technology
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Insect Resistance and Genetics
- RNA Interference and Gene Delivery
- Congenital heart defects research
- Image Enhancement Techniques
- Cardiac electrophysiology and arrhythmias
- Cardiomyopathy and Myosin Studies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cancer-related molecular mechanisms research
- Apelin-related biomedical research
- ATP Synthase and ATPases Research
- Planarian Biology and Electrostimulation
- Advanced Technologies in Various Fields
- Laser Design and Applications
- Photonic and Optical Devices
- Peptidase Inhibition and Analysis
Hainan University
2023-2024
Mayo Clinic in Arizona
2021-2024
Sanya University
2024
Xinjiang University
2023
Henan Normal University
2010
Harbin Institute of Technology
1993-2007
BACKGROUND: Apelin is an endogenous prepropeptide that regulates cardiac homeostasis and various physiological processes. Intravenous injection has been shown to improve contractility in patients with heart failure. However, its short half-life prevents studying impact on left ventricular remodeling the long term. Here, we aim study whether microparticle-mediated slow release of apelin improves function mice myocardial infarction (MI). METHODS: A patch was fabricated by embedding...
Background: Nanoparticles (NPs) have been extensively utilized as a drug delivery system to control the release of therapeutic agents treat cardiac injuries. However, despite advantages utilizing NP-based for treating heart diseases, current lacks specificity in targeting tissue, thus limiting its application. Methods: We created three linear peptides, each consisting 16–24 amino acids. These peptides were conjugated on surface NPs, resulting formation peptide (CTP)-NPs (designated CTP-NP1,...
The menisci are fibrocartilaginous tissues composed primarily of an interlacing network collagen fibers with nanoscale diameter. Electrospinning is a suitable process producing that mimic fibers. In this study, bilayered scaffold (group B), which consists gelatin nanofiber mesh and PLGA mesh, has been fabricated through electrospinning method. At the same time, we electrospun pure fibrous A) gelatin/PLGA composite C) as control groups. order to compare all morphologies, scaffolds were imaged...
The objective of the current study is to develop a new method for tracking transplanted human induced pluripotent stem cells-derived cardiomyocytes (hiPSC-CMs) using magnetic resonance imaging (MRI). CRISPR/dCas9 activation system employed overexpress ferritin heavy chain (FHC) in hiPSC-CMs. mRNA and protein expression FHC hiPSC hiPSC-CMs significantly increased after transfection. Iron chloride does not affect cell viability concentration range from 0 2000 µm. hiPSCs overexpressing (hiPSC-
Acute myocardial infarction is a leading cause of death worldwide. We have previously identified two cardioprotective molecules - FGF1 and CHIR99021- that confer cardioprotection in mouse pig models acute infarction. Here, we aimed to determine if improved metabolism contributes this cardioprotection. Nanofibers loaded with CHIR99021 were intramyocardially injected ischemic myocardium adult mice immediately following surgically induced Animals euthanized 3 7 days later. Our data suggested...
We evaluated the metabolic profile in pig hearts at postnatal day 1, 3, 7, and 28 (P1, P3, P7, P28, respectively) using a targeted liquid chromatography tandem mass spectrometry assay. Our data showed that there is clear separation of detected metabolites P1 vs. P28 hearts. Active anabolisms nucleotide proteins were observed when cardiomyocytes retain high cell cycle activity. However, active posttranslational protein modification, switch from glucose to fatty acids, reduced ratio collagen...
Little is known about the expression patterns and functions of circular RNAs (circRNAs) in heart large mammals. In this study, we examined profiles circRNAs, microRNAs (miRNAs), messenger (mRNAs) neonatal pig hearts. Pig samples collected on postnatal days 1 (P1), 3 (P3), 7 (P7) 28 (P28) were sent for total RNA sequencing. Our data revealed a 7000 circRNAs 24 Pathway enrichment analysis hallmark gene sets demonstrated that differentially expressed are engaged different pathways. The most...
Introduction: Neonatal pig hearts exhibit remarkable regenerative capacity within two days post-birth. In this study, we propose that a comprehensive multiomics analysis encompassing circRNA, miRNA, and mRNA data from neonatal mouse can unveil intricate circRNA-miRNA-mRNA relationships associated with cardiac regeneration. Our aim is to identify new novel circRNAs miRNAs implicated in cardiomyocyte proliferation through leveraging analysis. Methods: Utilizing hearts, conducted sequencing...
Mango stem-end rot caused by
Heart disease continues to be the leading cause of death globally, even with development and implementation numerous pharmacological surgical treatments. Transplanting cardiomyocytes derived from human-induced pluripotent stem cells (hiPSC-CMs) shows potential for repairing heart damage. However, tracking quantifying these after transplantation in large animals remains challenging. This study aimed develop a hiPSC line that overexpresses ferritin heavy chain (FHC) enable transplanted...
Cardiomyocytes in postnatal hearts undergo hypertrophy to adapt increased blood pressure and volume. The process of cardiomyocyte maturation is associated with a cessation from cell cycle series metabolic switches. Prior research has shown switches developing mouse hearts. However, changes pig have not been reported.We evaluated the profile at day 1 (P1), 3 (P3), 7 (P7), 28 (P28) (n=6 each, both males females; Yorkshire-Landrace Cross background) using targeted liquid chromatography tandem...
In order to improve the driving safety of high-altitude highway tunnel entrance section, physiological changes drivers passing through section under a hypoxic environment were studied. Build low-oxygen and conduct real vehicle tests collect test data such as illumination, speed, heart rate. The single factor analysis method was used significant differences in data, analyze influence illumination speed on rate growth at tunnel, establish relationship model between results show that: sharp...
Mango stem-end rot caused by Lasiodiplodia theobromae is a major postharvest disease resulting in considerable loss during storage and transportation China. Prochloraz, demethylation inhibitor, commonly used for control mango orchards storage. However, resistance to prochloraz has been found L. of mango. This study aimed explore the mechanisms responsible using biochemical molecular methods. The results showed that no mutations were LtCYP51 gene resistant strains. higher expression was...
Based on the reflective principle, a new kind of laser and fiber optic sensor system was proposed designed based formidable on-site operation conditions with temperature over 700 degree(s)C, abominable electromagnetic interference hard mounting problems. The optical is total fabric which has high performance for high-temperature, very good insulating property. It particularly suitable those special accessions that conventional sensors are difficult to apply. Because superiorities this such...
Modulated principles of various intensity-based sensors and their industrial applications are presented in this paper. We also a novel fiber optic sensor with special construction like spoke the was composed single mode emitting as well eight multimode receiving fibers. This can compensate light fluctuation reflectivity variation measured surface. What's more, arrangement fibers, it improve slope impact case is used to measure value spatial height Thus, be complex surface contour fairly good...
Optical fiber interference target flowmeter. In this paper theories of the flowmeter and its damper are demonstrated, structure is given. Experiments have been done to study relationship between damping index clearance, clearance viscosity under a fix index, three kinds clearance. The experimental results showed that designed system could slow down deformation speed cantilever used in and, furthermore, drifting fringes. This will cut cost
Background: It has been reported that metabolic correction improves success of heart failure treatment. We have previously identified two cardioprotective chemicals, the FGF1 and CHIR99021 confer cardioprotection in mouse pig models acute myocardial infarction. Here, we aim to determine if improved metabolism contributes mediated cardioprotection. Methods: Myocardial infarction (MI) was surgically induced 8-10 weeks old C57/B6 mice. Nanofibers loaded with or without were intramyocardially...