A5048651661- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Reproductive Biology and Fertility
- RNA modifications and cancer
- Microstructure and mechanical properties
- Ovarian function and disorders
- Pluripotent Stem Cells Research
- Cancer-related molecular mechanisms research
- CRISPR and Genetic Engineering
- Epigenetics and DNA Methylation
- Sperm and Testicular Function
- Bioinformatics and Genomic Networks
- Aluminum Alloy Microstructure Properties
- Computational Drug Discovery Methods
- Renal and related cancers
- Circular RNAs in diseases
- Advanced Welding Techniques Analysis
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- Crystallography and molecular interactions
- Pharmacological Effects of Natural Compounds
- Ginseng Biological Effects and Applications
- Cancer-related gene regulation
- Estrogen and related hormone effects
- Medicinal Plants and Bioactive Compounds
Affiliated Hospital of Hebei University
2016-2025
Second Affiliated Hospital of Nanjing Medical University
2020-2025
Columbia University Irving Medical Center
2020-2025
Affiliated Hospital of Guizhou Medical University
2021-2024
Zhejiang University
2013-2024
Zhejiang Lab
2022-2024
Gansu University of Traditional Chinese Medicine
2024
Hangzhou Botanical Garden
2023-2024
Guiyang Medical University
2021-2024
Anhui Agricultural University
2017-2022
Summary Tea trichomes synthesize numerous specialized metabolites to protect plants from environmental stresses and contribute tea flavours, but little is known about the regulation of trichome development. Here, we showed that CsMYB1 involved in formation galloylated cis ‐catechins biosynthesis plants. The variations expression levels are closely correlated with indexes contents plant populations. Genome resequencing may be selected modern cultivars, since a 192‐bp insertion promoter was...
Abstract Objective Numerous observations implicate interferon‐α (IFNα) in the pathophysiology of systemic lupus erythematosus (SLE); however, potential impact endogenous anti‐IFNα autoantibodies (AIAAs) on IFN‐pathway and disease activity is unclear. The aim this study was to characterize serologic clinical profiles AIAA‐positive patients with SLE. Methods Sera obtained from SLE (n = 49), rheumatoid arthritis 25), healthy control subjects 25) were examined for presence AIAAs, using a...
Soybean is an important oilseed crop and major dietary protein resource, yet the molecular processes regulatory mechanisms involved in biosynthesis of seed storage substances are not fully understood. The B3 domain transcription factor LEC2 essentially regulates embryo development maturation other plants, but functionally characterized soybean. Here, we characterize function a soybean homolog, GmLEC2a, regulating carbohydrate catabolism, triacylglycerol (TAG) biosynthesis, development....
Papillary thyroid carcinoma (PTC) is one of the most common kinds endocrine-related cancer and has a heterogeneous prognosis. Metabolic reprogramming hallmarks cancers. Aberrant glucose metabolism associated with malignant biological behavior. However, functions mechanisms genes in PTC are not fully understood. Thus, data from The Cancer Genome Atlas database were analyzed, lactate dehydrogenase A (LDHA) was determined to be potential novel diagnostic therapeutic target for PTCs. research...
Xuanfei Baidu Formula (XBF) is an effective traditional Chinese medicine (TCM) remedy for treating coronavirus disease 2019 (COVID-19) in China. This herbal has shown effects reducing clinical symptoms and shortening the average length of hospital stay COVID-19 patients. Previous studies have demonstrated that XBF alleviates acute lung injury (ALI) by regulating macrophage-mediated immune inflammation, but mechanisms action remain elusive. study aimed to evaluate lung-protective...
Serum response factor (SRF), a member of the MCM1, agamous, deficiens, SRF (MADS) family transcriptional activators, has been implicated in control number cardiac muscle genes, including α-actin, skeletal α-myosin heavy chain (α-MHC), and β-MHC. To better understand vivo role regulating genes responsible for maintenance function, we sought to test hypothesis that increased cardiac-specific expression might be associated with altered morphology function. We generated transgenic mice...
The high incidence of complex diseases has become a worldwide threat to human health. Multiple targets and pathways are perturbed during the pathological process diseases. Systematic investigation relationship between drugs is necessary for new association discovery drug repurposing. For this purpose, three causal networks were constructed herein cardiovascular diseases, diabetes mellitus, neoplasms, respectively. A inference-probabilistic matrix factorization (CI-PMF) approach was proposed...
Abstract It has been reported that lipid biosynthesis in plant host root cells plays critical roles legume‐fungal or ‐rhizobial symbioses, but little is known about its regulatory mechanism legume–rhizobia interaction. Soybean WRINKLED1 ( WRI1 ) a and b , with their alternative splicing (AS) products a’ b’ are highly expressed developing seeds nodules, functions soybean nodulation not known. GmWRI1a differently promoted triacylglycerol (TAG) accumulation both Arabidopsis wild‐type wri1...
Theaflavins (TFs) are generated by endogenous polyphenol oxidase (PPO)- and peroxidase (POD)-catalyzed catechins oxidation during black tea processing, which needs to be well-controlled obtain a proper TFs/thearubigins (TRs) ratio for better quality. Not all leaves from any plant cultivars or varieties suitable making high-quality teas, regardless of the processing techniques. The mechanisms underlying TFs formation main factors determining leaf suitability not fully understood. We here...
Kaixinsan (KXS) is a noteworthy classical prescription, which consists of four Chinese medicinal herbs, namely Polygalae Radix, Ginseng Radix et Rhizoma, Poria, and Acori Tatarinowii Rhizoma. KXS was initially documented in the ancient book Beiji Qianjin Yaofang written by Sun Simiao Tang Dynasty 652 A.D. As traditional medicine (TCM) it functions to nourish heart replenish Qi, calm tranquilize mind, excrete dampness. Originally used treat amnesia, now also effective memory decline applied...
TMEM16A plays an important role in cell proliferation various cancers. However, less was known about the expression and of hepatocellular carcinoma. We screened patients' carcinoma tissues, also analyzed biological function cells by knockdown TMEM16A, as well MAPK signaling proteins, including p38, p-p38, ERK1/2, p-ERK1/2, JNK, p-JNK, cycle regulatory protein cyclin D1 siRNA-transfected SMMC-7721 Western blot. Our results showed that overexpressed tissues. Inhibition suppressed...
Oil tea trees produce high-quality edible oils with desirably high oleic acid (18:1) and low linoleic (18:2) linolenic (18:3) fatty (FA) levels, but limited understanding of oil biosynthesis regulation has become a significant obstacle for the breeding high-yield -quality varieties. By integrating metabolite transcriptome analyses developing seeds, we dissected critical metabolic pathways, including glycolysis, acid, triacylglycerol (TAG) biosynthesis, as well genes essential seed...
The safety and effectiveness of short-term insemination remain a subject controversy. This study aims to investigate the impact on both embryo quality pregnancy outcomes whether it is necessary apply all patients underwent in vitro fertilization (IVF). A retrospective analysis was conducted 3,496 from two centers over period January 2016 December 2022. Of these, 1307 IVF, 1656 were treated with 166 received early rescue intracytoplasmic sperm injection (R-ICSI) 367 ICSI. clinical neonatal...
Testis-specific transcript 10 (Tex10) is highly expressed in the testis, embryonic stem cells (ESCs), and primordial germ (PGCs). We previously generated a Tex10 knockout mouse model demonstrating its critical roles ESC pluripotency preimplantation development. Here, using conditional mice dTAG-degron ESCs, we show required for spermatogenesis ESC-to-PGCLC differentiation. Specifically, Tex10-null spermatocytes arrest at metaphase I, compromising round spermatid formation. depletion...
Abstract Pancreatic stellate cells (PSCs) contribute to pancreatic ductal adenocarcinoma (PDAC) progression and therapeutic resistance, yet their detailed functions remain unclear. This study combined RNA sequencing assay for transposase‐accessible chromatin using (ATAC‐seq) on sorted PSCs from adjacent normal PDAC tissues investigate transcriptional epigenetic activation. heterogeneity are characterized through bulk, single‐cell, spatial transcriptomes, as well in situ sequencing. The...
The role of parity before and after N-methyl-N-nitrosourea (MNU) treatment in protection against mammary carcinogenesis was investigated. effect lactation on reduction the incidence carcinoma also examined. Parous rats were compared with respective age-matched virgins (AMVs). Pregnancy prior to MNU exposure significantly reduced both (22 versus 72%) average number carcinomas per rat (0.22 0.86) prolonged latency (247 215 days). following (25 94%) (0.25 1.50) (240 155 Lactation showed an...
Chinese medicine has evolved from thousands of years empirical applications and experiences combating diseases. It become widely recognized that the acts through complex mechanisms featured as multicompound, multitarget multipathway. However, there is still a lack systematic experimental studies to elucidate medicine. In this study, differentially expressed genes (DEGs) were identified myocardial infarction rat model treated with Xuesaitong Injection (XST), consisting total saponins Panax...
Translational control has emerged as a fundamental regulatory layer of proteome complexity that governs cellular identity and functions. As initiation is the rate-limiting step translation, we carried out an RNA interference screen for key translation factors required to maintain embryonic stem cell (ESC) identity. We identified eukaryotic factor 4A2 (eIF4A2) defined its mechanistic action through ribosomal protein S26-independent -dependent ribosomes in activation messenger RNAs (mRNAs)...
Abstract In order to investigate the metabolic characteristics of human follicular fluid (FF) and reveal potential predictors development (FD) with clinical implications, we analyzed a total 452 samples based on two-stage study design. first stage, FF from both large follicles (LFs) matched-small (SFs) 26 participants were wide-spectrum targeted metabolomics. The signatures described by multi-omics integration technology including metabolomic data transcriptomic data. second biomarkers FD...