A5075554519- Connective Tissue Growth Factor Research
- Biomarkers in Disease Mechanisms
- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- TGF-β signaling in diseases
- Gastroesophageal reflux and treatments
- Cancer-related gene regulation
- Inflammatory mediators and NSAID effects
- Digestive system and related health
- Eosinophilic Esophagitis
- Wnt/β-catenin signaling in development and cancer
- Esophageal Cancer Research and Treatment
- Angiogenesis and VEGF in Cancer
- ATP Synthase and ATPases Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Eicosanoids and Hypertension Pharmacology
- Metastasis and carcinoma case studies
- RNA Research and Splicing
- Neural dynamics and brain function
- Drug Transport and Resistance Mechanisms
- Medicinal plant effects and applications
- Cell death mechanisms and regulation
- Neuroscience and Music Perception
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
Inner Mongolia University of Science and Technology
2017-2025
Baotou Medical College
2017-2025
Chongqing Academy of Animal Science
2025
The Second Affiliated Hospital of Bengbu Medical College
2023
University of California, Irvine
2007-2022
VA Long Beach Healthcare System
2007-2022
Zhejiang Sci-Tech University
2022
Udayana University
2022
City University of New York
2022
Mongolian University of Science and Technology
2022
Serum response factor (SRF), a member of the MCM1, agamous, deficiens, SRF (MADS) family transcriptional activators, has been implicated in control number cardiac muscle genes, including α-actin, skeletal α-myosin heavy chain (α-MHC), and β-MHC. To better understand vivo role regulating genes responsible for maintenance function, we sought to test hypothesis that increased cardiac-specific expression might be associated with altered morphology function. We generated transgenic mice...
Angiogenesis, new capillary blood vessel formation, is essential for embryonic development, wound healing, and cancer growth. Vascular endothelial growth factor (VEGF) induces angiogenesis by activating cell migration proliferation. Serum response (SRF) a transcription important development activation of immediate early gene expression. The roles SRF in biology have not been explored. Here we demonstrate that downstream mediator VEGF signaling cells critical requirement VEGF-induced...
CCN1 is a matricellular protein highly expressed in esophageal squamous cell carcinoma (ESCC) but hardly detectable adenocarcinoma (EAC). Expression of EAC cells leads to TRAIL-mediated apoptosis. Unlike TRAIL, which primarily triggers death, APRIL and BAFF promote growth via NFκB signaling. They become active ligands by Furin cleavage. This study found that upregulated expression both ESCC attenuated their signaling the latter. kept stable allowing APRIL/BAFF signal through common receptor...
The prediction and diagnosis of breast cancer relies on multimodal data, such as imaging, genetic information, patient lifestyle habits. Federated learning provides a framework to protect data privacy, allowing multiple institutions share model training without sharing the original data. This paper proposes combined with federated learning, where each participant trains locally using genes, treatment history. During local process, is normalized feature extracted, initially classified support...
<b>Background:</b> Myofibroblast differentiation is a key event during wound healing and triggered primarily by transforming growth factor β (TGFβ). Serum response (SRF) TGFβ-inducible transcription that important for healing. Injection of SRF expression plasmid into rat gastric ulcers significantly accelerated restoration epithelium smooth muscle structures. <b>Aim:</b> To determine the role in oesophageal ulcer healing, especially myofibroblast differentiation. <b>Subjects:</b> Rats (in...
Summary Background Dysplasia and malignant transformation of colonocytes in ulcerative colitis are associated with overexpression c‐Myc genes regulating cell survival. 5‐Aminosalicylates such as mesalazine may reduce the development colorectal cancer colitis, but mechanisms its chemopreventive action not clear. Aims To examine whether affects expression human colon lines. Methods Human cells were treated vehicle or (4 m 40 ). We examined: (i) mRNA by gene array, (ii) protein Western blotting...
DNA mutation is a common event in the human body, but most situations, it fixed right away by damage response program. In case too severe to repair, programmed cell death system will be activated get rid of cell. However, if affects some critical components this system, genetic scars are kept and multiply through mitosis, possibly leading cancer someday. There many forms death, apoptosis necroptosis represent default backup strategy, respectively, maintenance optimal population as well...