A5101396944- Heme Oxygenase-1 and Carbon Monoxide
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Diet and metabolism studies
- MicroRNA in disease regulation
- Adipose Tissue and Metabolism
- Acute Myeloid Leukemia Research
- Retinal Imaging and Analysis
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Congenital heart defects research
- Muscle metabolism and nutrition
- Cardiac and Coronary Surgery Techniques
- Cancer, Lipids, and Metabolism
- Berberine and alkaloids research
- Autophagy in Disease and Therapy
- Mycobacterium research and diagnosis
- Retinopathy of Prematurity Studies
- Hematological disorders and diagnostics
- Diabetes and associated disorders
- Retinal Diseases and Treatments
- Immune Response and Inflammation
- Neuroinflammation and Neurodegeneration Mechanisms
- Angiogenesis and VEGF in Cancer
- Thermal Regulation in Medicine
Baotou Medical College
2020
Inner Mongolia University of Science and Technology
2020
Academy of Military Medical Sciences
2019
Zhejiang Entry-Exit Inspection and Quarantine Bureau
2017-2018
Xi’an Children’s Hospital
2017
Guiyang Medical University
2015
Nanyang Medical College
2015
The present study aimed to determine whether an miRNA (miR)-29b inhibitor protected against cerebral ischemia/reperfusion (I/R) injury in vitro and investigate the underlying mechanisms. As a model for induced IR injury, N2a cells were exposed oxygen-glucose deprivation/reoxygenation (OGD/R) environment. Using this model, it was demonstrated that miR-29b significantly upregulated compared with normal interactions between myeloid cell leukemia sequence (MCL)-1 then investigated using...
Abstract Ischemic cerebral stroke is a leading cause of death and long‐term disability world‐wide. Neuronal injury following ischemia initiates complex series signaling cascades that lead to neuronal cell death. MicroRNA 29b (miR‐29b) has reported involvement in the pathogenic process ischemic brain injury. Dexmedetomidine (Dex) highly selective α 2 adrenergic receptor stimulant exerts protective effect on tissue. To determine whether Dex might directly influence miR‐29b expression after an...
Heme oxygenase-1 was reported previously as a resistance target on acute myelocytic leukemia (AML). We found that HO-1 resistant to 5-azacytidine (AZA) treatment of myelodysplastic syndrome (MDS), and explored further the relative mechanisms. Patient bone marrow mononuclear cells (n=48) diagnosed different levels MDS were collected. Cell growth evaluated by MTT assay; cell cycle apoptosis detected flow cytometry; mRNA expression assessed real-time PCR, protein analyzed through western...
Sinomenine has been reported to effectively repress the progression of lung cancer and breast cancer. However, effects sinomenine in bladder are not well understood. The purpose this study was evaluate cancer.The mRNA expression HEIH cells measured by RT-qPCR. T24 SW780 were treated with for 24 hours. Cell viability detected MTT assay. migration invasion transwell Western blotting assay performed assess protein Bcl-2, Bax, caspase-3.Sinomenine significantly suppressed cell cells. Moreover,...
We evaluated the influence of heme oxygenase-1 (HO-1) gene inhibition in myelodysplastic syndrome (MDS) cell line SKM-1 on enhancement demethylating effects decitabine p15, and explored possible mechanism.DNMT1 expression cells was silenced by being transfected a constructed siRNA with liposomes.The proliferation rates after drug treatment were detected counting kit-8 assay.The apoptotic Annexin V/PI assay flow cytometry.The expressions p16, TP73, CDH1, ESR1, PDLIM4 mRNAs real-time PCR,...
To investigate the effects of Listeria monocytogenes infection on hematopoietic stem and progenitor cell (HSPC) composition, cycle colony-forming ability in mouse bone marrow.The C57BL/6J mice were divided into infected group control group. The injected intraperitoneally with 6.7×106 CFU monocytogenes,while injecfed PBS same volume.The serum levels IFNγ detected at different time points. After 24 hours, HS/PC marrow measured, difference between was statistically analyzed.Serum peaked hours...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)