A5057179164- Reproductive Biology and Fertility
- Ovarian function and disorders
- Sperm and Testicular Function
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive Health and Technologies
- Gastrointestinal disorders and treatments
- Reproductive System and Pregnancy
- Renal and related cancers
- Esophageal and GI Pathology
- Diverticular Disease and Complications
- Ovarian cancer diagnosis and treatment
- Reproductive tract infections research
- Aldose Reductase and Taurine
- Prenatal Screening and Diagnostics
- Hypothalamic control of reproductive hormones
- Autoimmune and Inflammatory Disorders Research
- Pluripotent Stem Cells Research
- Ion Transport and Channel Regulation
- Cancer, Stress, Anesthesia, and Immune Response
- Endometriosis Research and Treatment
- Mitochondrial Function and Pathology
- Gastrointestinal Tumor Research and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Drug-Induced Hepatotoxicity and Protection
- Gastric Cancer Management and Outcomes
Second Affiliated Hospital of Nanjing Medical University
2014-2025
Nanjing Medical University
2005-2025
Nanjing University
2025
Nanjing University of Chinese Medicine
2010
Jiangsu Province Hospital
2010
GTx (United States)
2001
Abstract In order to investigate the metabolic characteristics of human follicular fluid (FF) and reveal potential predictors development (FD) with clinical implications, we analyzed a total 452 samples based on two-stage study design. first stage, FF from both large follicles (LFs) matched-small (SFs) 26 participants were wide-spectrum targeted metabolomics. The signatures described by multi-omics integration technology including metabolomic data transcriptomic data. second biomarkers FD...
Abstract The prevalence of chronic kidney disease (CKD) has been increasing over the past decades. However, no effective therapies are available for delaying or curing CKD. Progressive fibrosis is major pathological feature CKD, which leads to end-stage renal (ESRD). present study showed that Polo-like kinase 1 (Plk1) was upregulated in kidneys CKD patients and mice subjected unilateral ureteral obstruction (UUO) with location proximal tubules tubulointerstitial fibroblasts. Pharmacological...
The safety and effectiveness of short-term insemination remain a subject controversy. This study aims to investigate the impact on both embryo quality pregnancy outcomes whether it is necessary apply all patients underwent in vitro fertilization (IVF). A retrospective analysis was conducted 3,496 from two centers over period January 2016 December 2022. Of these, 1307 IVF, 1656 were treated with 166 received early rescue intracytoplasmic sperm injection (R-ICSI) 367 ICSI. clinical neonatal...
Polycystic ovary syndrome (PCOS) is a complex endocrine disorder that affects women. It can be accompanied by many clinical manifestations vary between individuals. Previous studies have found there are specific changes in the intestinal flora of PCOS patients, and interventions to modify significantly improve symptoms PCOS. Women with higher incidence vaginitis compared healthy Few to-date focused on investigating vaginal flora. Here, we aimed explore distribution microbiome patients. We...
Oxidative stress (OS) is one of the primary factors leading to male infertility. Oral administration antioxidants has thus far been found significantly improve quality human sperm. Therefore, antioxidant treatment become consensus among international experts on In this study, peroxisomal biogenesis factor 3 (Pex3)-knockout (KO, -/-) mice were used as a model compare efficacy three types traditional Chinese medicine (TCM) granules (Epimedium [YYH], Cuscuta [TSZ], and Rhodiola [HJT]) for...
Abstract Background To investigate the metabolic profiles in follicular fluid (FF) samples from patients undergoing vitro fertilization (IVF) and to analyze correlations with development. Methods The FF were obtained participants ( N = 26) who receiving IVF under gonadotropin-releasing hormone agonist (GnRH-a) long protocol stimulation collected separately small (8–13 mm) large (17–22 follicles at time of oocyte retrieval. Metabolomic analysis was performed using liquid chromatography-tandem...
Fertilisation failures occur in 2-3% of intracytoplasmic sperm injection (ICSI) cycles and are mostly caused by failure oocyte activation. Assisted activation (AOA) may be an efficient treatment option to overcome failure. To evaluate the effectiveness ICSI combined with AOA strontium, six couples complete fertilisation or low rates (ranging from 0% 16.7%; mean = 7.7%) previous were involved present study. In latest cycles, strontium was improve clinical outcomes. Fifty-two mature oocytes...
Nicotinamide (NAM) is an important antioxidant, which closely related to female fertility, but its role has not been clearly elucidated. The purpose of the present study was investigate effects NAM on follicular development at different stages and quality oocytes.The concentration in fluid (FF) 236 women undergoing vitro fertilization (IVF) ascertained by enzyme-linked immunosorbent assay (ELISA), correlation between clinical indexes analyzed. During maturation (IVM) mice cumulus-oocyte...
Abstract Mesangial cell (MC) proliferation is one of the important pathological features obesity-associated nephropathy with unknown etiology. Excessive MC can cause glomerulosclerosis and renal function loss. Thus, targeting may be a potential strategy for treatment kidney disease. The present study was undertaken to investigate role celastrol in induced by ox-LDL, as well mechanisms. Following ox-LDL treatment, NLRP3 inflammasome activated, evidenced increased levels, caspase 1 activity,...
Abstract STUDY QUESTION Are taurine and its transporter TAUT associated with spermiogenesis early embryo development? SUMMARY ANSWER Morphologically abnormal spermatozoa increased after local functional interference by intratesticular injection, depletion significantly reduced the normal numbers in vivo blastocyst formation rate vitro. WHAT IS KNOWN ALREADY Taurine is one of most abundant amino acids male reproductive system it has been demonstrated that can efficiently improve spermatogenic...
Abstract Background Ovarian responsiveness to controlled ovarian stimulation is essential for a successful clinical outcome in assisted reproductive technology (ART) cycles. We aimed find suitable new ovulation protocol poor response (POR) patients over 40 years old. Methods A retrospective analysis of 488 ART cycles was evaluated from January 2015 June 2019. Comparisons were made between the flexible short (FSP), routine and mild protocol. Results Compared with protocol, FSP delayed...
Mitochondrial dysfunction has been documented to play a crucial role in the pathogenesis of liver injury. In present study, we investigated rotenone, mitochondrial complex-1 inhibitor, carbon tetrachloride (CCl4) -induced acute injury, as well underlying mechanisms. Before CCl4 administration, mice were pretreated with rotenone at dose 250 ppm food for three days. Then was administered 16 h by intraperitoneal injection. The status, oxidative stress, and inflammation examined. Strikingly,...
Lithium is widely used in psychiatry as the golden standard for more than 60 yr due to its effectiveness. However, adverse effect has been limiting long-term use clinic. About 40% of patients taking lithium develop nephrogenic diabetes insipidus (NDI). can also induce proliferation collecting duct cells, leading microcyst formation kidney. was considered an autophagy inducer that might contribute therapeutic benefit neuropsychiatric disorders. Thus, we hypothesized may play a role...
Genetic screening is an important approach for etiology determination and helps to optimize administration protocols in reproductive centers. After the first pathogenic gene of female infertility was reported 2016, more new genes were discovered, we sought develop efficient cost-effective method genetic patients. In this study, designed a target-sequencing panel with 22 infertility-related genes, namely, TUBB8, PATL2, WEE2, PANX1 sequenced 68 primary (PI) recurrent pregnancy loss (RPL) We...
Delayed childbearing leads to increased assisted reproductive technology use by women of advanced maternal age (AMA). It is unclear whether fresh or frozen embryo transfer (FET) the better option. We aimed assess and neonatal outcomes in patients having their first FET after a freeze-all cycle versus those (ET). reviewed 720 AMA undergoing ET (n = 375) 345) between January 2016 April 2021. No significant difference live birth rate was found (19.7% vs. 24.3%, p 0.141). The clinical pregnancy...
A 68-year-old man was admitted to our hospital with right upper quadrant pain and jaundice. Laboratory studies revealed leukocytosis, elevated liver enzymes, hyperbilirubinemia. Magnetic resonance cholangiopancreatography examination distal bile duct stenosis. On duodenoscopy, the papilla hidden within a diverticulum. We tried using two devices simultaneously perform endoclip-assisted biliary cannulation but without success ([Fig. 1 a]). Thus, duodenoscope withdrawn gastroscope (GIF Q260;...
Objective To investigate the metabolic characteristics of follicular fluid (FF) from human ovarian follicles different developmental stages, and whether there are predictors development (FD) with clinical implications. Design A population-based study. Setting two-stage study a reproductive medicine center in Nanjing, China between 2019 2020. Population total 226 infertile women, tubal complications or unexplained sterility, experiencing their first vitro fertilization cycle. Methods main...
Abstract Purpose The proportion of patients with poor ovarian response (POR) is increasing, but effective treatment remains a challenge. To control the hidden peaks luteinizing hormone (LH) and premature ovulation for responders, this study investigated efficacy flexible short protocol (FSP) gonadotropin-releasing antagonist (GnRH-ant) on trigger day. Methods 662 cycles POR were retrospectively analyzed. cohort was divided into intervention groups. group (group A) 169 received GnRH-ant given...