A5100443504- Virus-based gene therapy research
- Cleft Lip and Palate Research
- Industrial Vision Systems and Defect Detection
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Diabetes and associated disorders
- Sexual Differentiation and Disorders
- Generative Adversarial Networks and Image Synthesis
- Image Enhancement Techniques
- Diabetes Management and Research
- Prenatal Screening and Diagnostics
- Orthodontics and Dentofacial Orthopedics
- Genetic diversity and population structure
- Protein purification and stability
- Immune Cell Function and Interaction
- Ovarian function and disorders
- RNA Interference and Gene Delivery
- Genetic and Kidney Cyst Diseases
- Genomics and Phylogenetic Studies
- Plant and Fungal Species Descriptions
- Face recognition and analysis
- CAR-T cell therapy research
- Renal and related cancers
- Digestive system and related health
- Nutrition, Genetics, and Disease
- Sperm and Testicular Function
Affiliated Hospital of Southwest Medical University
2024
First Affiliated Hospital of Zhengzhou University
2024
Kunming Medical University
2024
Fudan University
2024
Shanghai Stomatological Hospital
2024
Guangxi Medical University
2024
Stomatology Hospital
2024
Durham University
2022-2024
South China Agricultural University
2022-2023
Nanjing Medical University
2016-2023
OBJECTIVE Type 1 diabetes (T1D) is a highly heritable disease with much lower incidence but more adult-onset cases in the Chinese population. Although genome-wide association studies (GWAS) have identified >60 T1D loci Caucasians, less known Asians. RESEARCH DESIGN AND METHODS We performed first two-stage GWAS of using 2,596 autoantibody-positive case subjects and 5,082 control Han population evaluated associations between risk age fasting C-peptide levels at diagnosis. RESULTS...
Existing image inpainting methods leverage convolution-based downsampling approaches to reduce spatial dimensions. This may result in information loss from corrupted images where the available is inherently sparse, especially for scenario of large missing regions. Recent advances self-attention mechanisms within transformers have led significant improvements many computer vision tasks including inpainting. However, limited by computational costs, existing cannot fully exploit efficacy...
Abstract Background Renal interstitial fibrosis (RIF) is a progressive, irreversible terminal kidney disease with poor prognosis and high mortality. Angiopoietin-like 4 (ANGPTL4) known to be associated in various organs, but its impact on the RIF process remains unclear. This study aimed elucidate role underlying mechanisms of ANGPTL4 progression RIF. Methods In vivo, chronic (CKD) rat model renal was established via intragastric administration adenine at different time points (4 6 weeks)....
Antibody (Ab) structures and antibody-antigen interactions (AAIs) are essential for understanding immune recognition designing Ab therapeutics. While existing structural databases provide valuable insights, they still have notable limitations. Here, we present SAAINT-parser, an computational workflow rapid, accurate, robust extraction of AAI information from the Protein Data Bank (PDB). SAAINT-parser features precise detection chains, accurate pairing reliable identification AAIs. The...
Abstract The prevalence of chronic kidney disease (CKD) has been increasing over the past decades. However, no effective therapies are available for delaying or curing CKD. Progressive fibrosis is major pathological feature CKD, which leads to end-stage renal (ESRD). present study showed that Polo-like kinase 1 (Plk1) was upregulated in kidneys CKD patients and mice subjected unilateral ureteral obstruction (UUO) with location proximal tubules tubulointerstitial fibroblasts. Pharmacological...
Background Primary ovarian insufficiency (POI) is a common clinical endocrine disorder with high heterogeneity in both hormones and etiological phenotypes. However, the etiology of POI remains unclear. Herein, we unraveled causality genetically determined metabolites (GDMs) on through Mendelian randomization (MR) study overarching goal disclosing underlying mechanisms. Methods Genetic links 486 were retrieved from GWAS data 7824 European participants as exposures, while concerning utilized...
MicroRNAs are essential for the maintenance of podocyte homeostasis. Emerging evidence has demonstrated a protective role microRNA-30a (miR-30a), member miR-30 family, in injury. However, roles other family members injury unclear. The present study was undertaken to investigate contribution miR-30e pathogenesis induced by aldosterone (Aldo), as well underlying mechanism. After Aldo treatment, reduced dose-and time-dependent manner. Notably, overexpression markedly attenuated Aldo-induced...
To test the hypothesis that experimentally created physiologically nonbalanced occlusion will not affect thickness of temporomandibular joint (TMJ) discs in rats.Twenty-four 8-week-old Sprague-Dawley rats were equally divided into a control group was left untreated and an experimental where created. Elastic rubber bands, 1 mm diameter, inserted week later replaced by plastic material between first second molars maxillary right mandibular dentitions to move about 0.8 mesially. This maintained...
To examine the distribution and effects of subclass insulin antibodies on glucose control side events in patients with type 2 diabetes treated premixed analog.A total 516 analog were sequentially enrolled from First Affiliated Hospital Nanjing Medical University June 2016 to August 2020. Subclass-specific (IAs) (IgG1-4, IgA, IgD, IgE, IgM) detected IA-positive by electrochemiluminescence. We analyzed control, serum insulin, insulin-related between IA-negative groups, as well among different...
Accumulating studies have highlighted the significant role of circulating metabolomics in etiology reproductive system disorders. However, causal effects between genetically determined metabolites (GDMs) and diseases, including primary ovarian insufficiency (POI), polycystic ovary syndrome (PCOS), abnormal spermatozoa (AS), still await thorough clarification. With currently most comprehensive genome-wide association (GWAS) data metabolomics, systematic two-sample Mendelian randomization (MR)...
We present a software that predicts non-cleft facial images for patients with cleft lip, thereby facilitating the understanding, awareness and discussion of lip surgeries. To protect patients' privacy, we design framework using image inpainting, which does not require training, mitigating risk model leakage. implement novel multi-task architecture both landmarks, resulting in better performance as evaluated by surgeons. The is implemented PyTorch usable consumer-level color fast prediction...
Castanopsis is one of the most common genus trees in subtropical evergreen broad-leaved forests and tropical monsoon rainforests China. hainanensis wenchangensis are endemic to Hainan Island, but they were once confused as same species due very similar morphologies. In this study, nuclear microsatellite markers chloroplast genomes used delimit C. wenchangensis. The allelic variations microsatellites revealed that highly genetically differentiated with limited gene admixture. Both showed...
Abstract Objective: The inhibition of the neovascularization in tumors is a potential therapeutic target cancer. Vascular endothelial growth inhibitor (VEGI) member TNF superfamily which has ability to suppress formation new vessels tumors. In order study association between VEGI gene polymorphisms and breast cancer risk, case-control was conducted Chinese Han women Northeast China. Methods: Our involved 708 female patients 685 healthy volunteers. Four SNPs were analyzed through polymerase...
The effect of the combination a recombinant adenovirus (ATV) expressing specific apoptin protein and cisplatin on human lung cancer cells (A549 cells) was determined. inhibitory effects ATV cisplatin, alone, or alone migration invasion A549 were evaluated in vitro using cell proliferation, wound healing, Transwell Matrigel assays. tumor inhibition vivo assessed by observing growth survival rate nude mice with subcutaneous xenografts grown from implanted after treatment ATV, combined...
// Zhenkun Fu 1, * , Shuang Chen 2, Shengwei Liu 2 Shaoli Han Xiang Gao Dalin Li 3 Dianjun 1 Heilongjiang Provincial Key Laboratory for Infection and Immunity, Harbin Medical University Academy of Science, 150081 Harbin, China Department Immunology, Breast Surgery, The Third Affiliated Hospital University, Co-first author Correspondence to: Li, email: dianjunli@163.com lidalin1975@163.com Keywords: DcR3, TNFRSF6β, breast infiltrating ductal carcinoma, single nucleotide polymorphism,...
Existing image inpainting methods leverage convolution-based downsampling approaches to reduce spatial dimensions. This may result in information loss from corrupted images where the available is inherently sparse, especially for scenario of large missing regions. Recent advances self-attention mechanisms within transformers have led significant improvements many computer vision tasks including inpainting. However, limited by computational costs, existing cannot fully exploit efficacy...
Bimaxillary dentoalveolar protrusion is a frequent complain in orthodontic clinic. The incisor angulation and inclination have been largely discussed. present purpose was to assess the involvement of teeth distal incisors. In this cross-sectional study, 63 patients with Class I occlusion an average sagittal relationship between maxilla mandible were enrolled. Twenty-two cases (20.14 ± 7.32 years old) who had profile flaring upper lower incisors diagnosed as bimaxillary protrusion. other 41...
Cameras are essential vision instruments to capture images for pattern detection and measurement.Human-object interaction (HOI) is one of the most popular approaches captured human-centric visual scenes.Recently, Transformer-based models have become dominant approach HOI due their advanced network architectures thus promising results.However, them follow one-stage design vanilla Transformer, leaving rich geometric priors under-exploited leading compromised performance especially when...