A5005162789- Reproductive Biology and Fertility
- Ovarian function and disorders
- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive Health and Technologies
- Gynecological conditions and treatments
- Sperm and Testicular Function
- Prenatal Screening and Diagnostics
- Uterine Myomas and Treatments
- Ectopic Pregnancy Diagnosis and Management
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Heat shock proteins research
- Estrogen and related hormone effects
- Testicular diseases and treatments
- Connective Tissue Growth Factor Research
- Hormonal and reproductive studies
- Birth, Development, and Health
- Bone health and osteoporosis research
- Healthcare and Venom Research
- Cancer Cells and Metastasis
- Proteins in Food Systems
- Advanced Nanomaterials in Catalysis
- Hair Growth and Disorders
Nanjing Medical University
2013-2024
Reproductive Medicine Institute
2023
Jiangsu Province Hospital
2005-2022
Jiangsu Provincial Hospital of Traditional Chinese Medicine
2022
Nanjing General Hospital of Nanjing Military Command
2019
Nanjing Maternity and Child Health Care Hospital
2018
To investigate the effects of endometrial thickness (EMT) on pregnancy outcomes hCG trigger day in fresh vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) cycles.A total 42,132 cycles between 1 January 2013 31 December 2019 were included this retrospective cohort study. Data collected from five reproductive centers large academic or university hospitals China. All patients divided into different groups according to their day. Multivariate regression analysis, curve...
Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility, affecting 5-10% females reproductive age. Currently, little known about changes in whole proteins between PCOS and normal ovaries. In present study, a proteomic approach comprised two-dimensional gel electrophoresis (2DE) analysis mass spectroscopy was used to identify examine expression patterns three One hundred ten protein spots were separated showed different intensities Sixty-nine associated with...
Biochemical or clinical changes of hyperandrogenism are important elements polycystic ovary syndrome (PCOS). There is currently no consensus on the definition and diagnostic criteria in PCOS. The aim this study was to investigate complex symptoms hyperandrogenic disorders correlations between metabolism patients with PCOS from an outpatient reproductive medicine clinic China. We conducted a case control 125 130 controls evaluate differences body mass index (BMI), total testosterone (TT),...
Objective: To compare the influence of various tubal surgeries to ovarian reserve via serum level antimullerian hormone (AMH) and subsequent in vitro fertilization embryo transplantation (IVF-ET) outcome patients with simple infertility.Study design: A prospective cohort study was conducted on 134 IVF cycles undegone by 26 34 cases bilateral unilateral salpingectomy, respectively, 23 oviducts interrupted proximal 51 obstruction without intervention as controls.Results: Serum AMH displayed...
Human infertility is a growing concern and while many assisted reproductive technologies exist, their success rates are low. Thus, developing tests, possibly by assessing proteins involved in fertilization, that could predict the outcome of these great significance. To identify candidate proteins, we used two-dimensional polyacrylamide gel electrophoresis MALDI-TOF techniques detected ERp57 protein from human testis profile. Immunohistochemistry showed was mostly located spermatogenic cell...
This study aimed to explore the value of ovarian reserve tests (ORTs) for predicting poor ovary response (POR) and whether an age cutoff could improve this forecasting, so as facilitate clinical decision-making women undergoing in vitro fertilization (IVF). A retrospective cohort was conducted on patients using real-world data from five reproductive centers university-affiliated hospitals or large academic China. total 89,002 with infertility their first traditional stimulation cycle January...
Cytokines are key mediators of intercellular communication and likely to promote the development progression endometriosis. Previous studies provided evidence that endometriosis develops as a result pathogenetic factors in peritoneal environment, especially fluid (PF). We determined different cytokine expression between women with minimal/mild moderate/severe those without using array. As result, 78 cytokines were found have threefold change, including 74 increases four decreases compared...
Heat shock protein 27 (Hsp27) is a heat family member which can inhibit apoptosis. Our previous studies reported down-regulated Hsp27 in ovarian tissue derived from women with polycystic ovary syndrome (PCOS) however, the exact effect of on oocyte maturation and developmental competence PCOS unclear. The over-expression was studied vitro using oocytes patients. An artificial GFP-plasmid injected into human to increase level. Oocyte evaluated by morphological observation. Mature were...
Abstract Background In our previous study, endometrium side population cells (SP cells) were isolated from postpartum murine uterus, and characterized by a heterogeneous of stem/progenitor cells. this we investigated the effect estrogen on proliferation differentiation SP Methods non-SP DNA dye Hoechst 33342. The expression receptor 1 (ESR1) was measured reverse transcription polymerase chain reaction (RT-PCR), Real-time PCR, Western blot, immunofluorescence immunohistochemistry. treated...
Endometriosis is an estrogen-dependent disease. We previously found that the expression of Activin A was upregulated in peritoneal fluid patients with endometriosis. The results present study indicated induced estradiol secretion and P450arom endometrial stromal cells (ESCs) derived from endometriosis patients. mechanism estrogenic synthesis regulated by Activin-Smad pathway lesions. data showed effect on ESCs partially abrogated pretreatment inhibitor ALK4 (the type I receptor, ActRIB)...
Abstract Endometriosis is a common disease in women of childbearing age and closely associated with female infertility. However, the pathogenesis endometriosis-related infertility still not fully understood. Prohibitin 1 (PHB1), highly conserved protein related to mitochondrial function, differentially expressed endometrium patients endometriosis. role PHB1 glucose metabolism granulosa cells remains unclear. In this study, we investigated whether expression patterns differ endometriosis...
Luteinizing hormone (LH) is critical in follicle growth and oocyte maturation. However, the value of recombinant LH (r-LH) supplementation to stimulating (r-FSH) during controlled ovarian stimulation gonadotrophin releasing (GnRH) antagonist regimen controversial.This multicenter retrospective cohort study recruited 899 GnRH cycles stimulated with r-LH r-FSH 3 reproductive centers matched them 2652 using propensity score matching (PSM) for potential confounders a 1:3 ratio. The primary...
In Brief Elevated expression of miR-122-5p in exosomes the follicular fluid patients with endometriosis impairs glucose metabolism cumulus cells and may further impair oocyte quality. Abstract Endometriosis (EMs) affects fertility women childbearing age many ways. The underlying mechanisms, including decrease quality, require investigation. Exosomes, small vesicles responsible for intercellular information exchange, have been found to be involved biological events, follicle development...
Objective To study the influence of endometriosis activity on pregnancy outcomes patients with recurrent implantation failure (RIF) in in-vitro fertilization/intra-cytoplasmic sperm injection (IVF/ICSI) cycles. The were compared between RIF who received treatment at different occasions to explore appropriate plan for these and optimize pregnancy-support strategies. Design Ambispective cohort study. Methods A total 330 enrolled from 2008 2018 included 1043 IVF/ICSI All diagnosed after...