A5015930256- Pregnancy and preeclampsia studies
- Epigenetics and DNA Methylation
- Reproductive Biology and Fertility
- Prenatal Screening and Diagnostics
- Ovarian cancer diagnosis and treatment
- Birth, Development, and Health
- MicroRNA in disease regulation
- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Ovarian function and disorders
- Estrogen and related hormone effects
- Pancreatic and Hepatic Oncology Research
- Cancer-related molecular mechanisms research
- Sperm and Testicular Function
- Renal and related cancers
- Cancer Cells and Metastasis
- Endometrial and Cervical Cancer Treatments
- Genomics and Chromatin Dynamics
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- RNA Research and Splicing
- Cancer-related gene regulation
- Advanced biosensing and bioanalysis techniques
- Genetics and Neurodevelopmental Disorders
- Supercapacitor Materials and Fabrication
Nanjing Medical University
2018-2024
Kangda College of Nanjing Medical University
2024
Lianyungang Maternal and Children’s Hospital
2024
Nanjing Maternity and Child Health Care Hospital
2018-2023
Guangxi University
2023
Jiangnan University
2023
Women's Hospital
2023
Beijing University of Posts and Telecommunications
2021
Mercer University
2011-2020
State Key Laboratory of Reproductive Medicine
2020
HE4, also known as WFDC2, is a useful biomarker for ovarian cancer when either used alone or in combination with CA125. HE4 overexpressed endometrial (EC), but its function cells not clear. In this study, we investigate the role of EC progression. An HE4-overexpression system was established by cloning prototypic mRNA variant (HE4-V0) into eukaryotic expression vector. Following transfection, stable clones two cell lines were selected. The effects overexpression on growth and measured use...
Syncytin-1 is a protein coded by human endogenous retrovirus (HERV) gene of the HERV-W family (HERVWE1). Syncytin- 1 mediates formation syncytiotrophoblasts through fusion cytotrophoblasts, hallmark terminal differentiation placental trophoblast linage. also possesses nonfusogenic functions and regulates cell cycle progression. While decreased syncytin-1 expression syncytium deficiency are considered important pathological changes in preeclampsia, molecular mechanism(s) underlying...
Abstract DNA methylation is an inheritable chemical modification of cytosine, and represents one the most important epigenetic events. Computational prediction status can be employed to speed up genome-wide profiling, identify key features that are correlated with various patterns. Here, we develop CpGIMethPred, support vector machine-based models predict CpG islands in human genome under normal conditions. The for include those have been previously demonstrated effective (CpG island...
The aims of this study were to evaluate the contribution chromosomal microarray analysis (CMA) in prenatal diagnosis fetuses with central nervous system (CNS) anomalies but normal karyotype. A total 46 CNS or without other ultrasound karyotypes evaluated by array-based comparative genomic hybridisation (aCGH) single-nucleotide polymorphism (SNP) array. result showed that CNVs detected 17 (37.0%) fetuses. Of these, identified 5 (5/46, 10.9%) considered be likely pathogenic, and 3 (3/46, 6.5%)...
// Xin Sun 1, * , Shiwen Jiang 2, Jian Liu 1 Huangzhen Wang Yiwen Zhang Shou-Ching Tang 3, 4 Jichang 5 Ning Du Chongwen Xu Chenguang 6 Sida Qin Jia Dapeng Yunfeng Xiaojun Li Jiansheng Jun Dong 7 8 Shaohua 9 Zhen Tao 10 Fei 11 Jie Zhou 12 13 Hong Ren Department of Thoracic Surgery and Oncology, the First Affiliated Hospital Xi’an Jiaotong University, Xi’an, Shaanxi Province, 710061, China 2 Obstetrics Gynecology, Second Wenzhou Medical Wenzhou, Zhejiang 325027, 3 Breast Cancer...
The enzyme 3beta-hydroxysteroid dehydrogenase/isomerase (3betaHSD) is required for the biosynthesis of all active steroid hormones. It exists as multiple isoforms in humans and rodents, each a product distinct gene. Two isoforms, 3betaHSD I II, are expressed tissue-specific manner humans. only isoform placenta, where it progesterone thus essential maintenance pregnancy. We recently identified two transcription factors, activating protein-2gamma (AP-2gamma) homeodomain protein, distaless-3...
Antisense transcription is a widespread phenomenon in the mammalian genome and believed to play role regulating gene expression. However, exact functional significance of antisense largely unknown. Here, we show that natural (AS) RNA an important modulator interferon-α1 (IFN-α1) mRNA levels. A ~4-kb, spliced IFN-α1 AS targets single-stranded region within conserved secondary structure element mRNA, which was previously reported function as nuclear export element. Following infection human...
The aim of this study was to present a rare neoplasm, Primary myoepithelial carcinoma arising from the palate, and review its diagnostic criteria, pathologic clinical characteristics, treatment options prognosis.Myoepitheliomas are tumors cells mainly or exclusively. Myoepitheliomas mostly occur in salivary glands, as well breast, skin, lung. Case myoepitheliomas palate has rarely been reported. Myoepithelial is malignant counterpart myoepitheliomas. Adenomyoepithelioma also different...
Human epididymis protein 4 (HE4) is a recognized biomarker in ovarian and endometrial cancer over-expressed pancreatic adenocarcinoma. The diagnostic value of HE4 adenocarcinoma remains unknown. Here we elucidate mRNA, serum level mRNA tumor adjacent tissues were tested by real time-PCR. Tissue microarray containing normal, adenocarcinoma, tissue was immunohistochemistry (IHC). Serum HE4, carbohydrate antigen 19-9 (CA19-9), 15-3 (CA15-3) 125 (CA125) detected ELISA assay control patients....
The human endogenous retroviral family W, Env(C7), member 1 gene (HERVWE1) is thought to participate in trophoblast cell fusion, and its expression diminished the placentas of singleton intrauterine growth-retarded pregnancies. However, there limited information about role HERVWE1 discordant fetal growth twins. This study was compare between monozygotic twins identify regulation by methylation.Fetuses from twenty-one pairs monozygotic, dichorionic, were marked as "smaller" or "larger"...
DNA methylation plays a critical role in the regulation of gene expression, genomic stability, cell proliferation, and malignant transformation. Common cellular features including fast tissue expansion, invasive growth, active angiogenesis, have been noticed between placental development tumorigenesis by many investigators. While hypomethylation transcriptional activation LINE-1 has found to be feature tumorigenesis, it is not clear if similar changes could involved development. In this...