A5054453464- Glioma Diagnosis and Treatment
- Cancer-related cognitive impairment studies
- Cancer Cells and Metastasis
- S100 Proteins and Annexins
- MicroRNA in disease regulation
- Advanced Proteomics Techniques and Applications
- Geological and Geochemical Analysis
- Immune Response and Inflammation
- Gut microbiota and health
- Autophagy in Disease and Therapy
- Dementia and Cognitive Impairment Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Cancer survivorship and care
- Head and Neck Surgical Oncology
- Epigenetics and DNA Methylation
- Music Therapy and Health
- Cancer Mechanisms and Therapy
- Nanoplatforms for cancer theranostics
- Wound Healing and Treatments
- Pituitary Gland Disorders and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Nanoparticle-Based Drug Delivery
- Pancreatic and Hepatic Oncology Research
- Signaling Pathways in Disease
- Geological and Geophysical Studies
Affiliated Hospital of Southwest Medical University
2016-2025
Southwest Medical University
2013-2025
Takeda (United States)
2025
Tongji University
2023-2024
Tongji Hospital
2023-2024
Yunnan University
2023-2024
Shanghai Jiao Tong University
2023-2024
Wuhan University of Science and Technology
2024
Lanzhou University
2024
Hainan Medical University
2024
Circulating cell-free DNA (cfDNA) released by damaged cells causes inflammation and has been associated with the progression of sepsis. One proposed strategy to treat sepsis is scavenge this inflammatory circulating cfDNA. Here, we develop a cfDNA-scavenging nanoparticle (NP) that consists cationic polyethylenimine (PEI) different molecular weight grafted zeolitic imidazolate framework-8 (PEI-g-ZIF) in simple one-pot process. PEI-g-ZIF NPs fabricated using PEI 1800 25k but not 600 suppressed...
Almost all high-grade gliomas, particularly glioblastoma (GBM), are highly migratory and aggressive. Migrasomes organelles produced by cells capable of mediating intercellular communication. Thus, GBM may produce migrasomes during migration. However, it remains unclear whether can influence migration invasion. In this study, we observed the presence formation in cells. We found that expression levels key migrasome factor, tetraspanin 4 (TSPAN4), correlated positively with pathological grade...
Total resection of adamantinomatous craniopharyngioma (ACP) is complex and often leads to postoperative recurrence. This due the tendency tumor invade surrounding brain tissue generation a local inflammatory state between cells parenchyma. While there evidence suggest that interleukin‑6 (IL‑6) induces (CP)‑associated inflammation, particularly in ACP, role IL‑6 progression ACP remains unclear. The results present study demonstrated CP inflammation was associated with pathological...
Photothermal therapy (PTT) is an effective treatment modality that highly selective for tumor suppression and a hopeful alternative to traditional cancer therapy. However, PTT-induced inflammatory responses may result in undesirable side effects including increased risks of recurrence metastasis. Here we developed multifunctional MnO nanoparticles as scavengers proinflammatory molecules alleviate the response. The improve PTT by (1) binding scavenging inhibit molecule-induced Toll-like...
Abstract Chemotherapy, although effective against primary tumors, may promote metastasis by causing the release of proinflammatory factors from damaged cells. Here, polymeric nanoparticles that deliver chemotherapeutics and scavenge simultaneously to inhibit chemotherapy‐induced breast cancer are developed. The cationic can adsorb cell‐free nucleic acids (cfNAs) based on charge–charge interaction, which downregulates expression Toll‐like receptors then reduces secretion inflammatory...
ABSTRACT Purpose Immune globulin infusion (human) 10% solution (GAMMAGARD LIQUID; GGL), an intravenous immunoglobulin (IVIG), has recently received U.S. approval for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). We evaluated thrombotic events, acute kidney injury (AKI), and hemolytic events among patients with CIDP initiating IVIG treatment GGL, versus a U.S.‐approved comparator CIDP, in individual combined cohorts of (Ig)‐naive Ig‐experienced participants. Methods This...
Objective: To evaluate the early efficacy and safety of transnasal endoscopic surgical resection orbital cavernous hemangioma (OCH) at by intranasal technique (ORBIT) stage Ⅲ. Methods: A retrospective study was conducted on 20 patients (20 eyes) who underwent nasal surgery to remove ORBIT Ⅲ OCH Third Hospital Peking University from July 2021 2024. The cohort were included 10 males females, aged 25 59 years, with a mean follow-up time (5.10±4.51) months. Preoperative symptoms visual field...
Background: P-glycoprotein (P-gp) mediated drug efflux across the blood–brain barrier (BBB) is an important mechanism underlying poor brain penetration of certain antiepileptic drugs (AEDs). Nanomaterials, as carriers, can overcome P-gp activity and improve targeted delivery AEDs. However, their applications in AEDs have not been adequately investigated. The objective this study was to develop a nano-scale system solubility lamotrigine (LTG). Methods: LTG-loaded Pluronic ® P123 (P123)...
// Xin Sun 1, * , Shiwen Jiang 2, Jian Liu 1 Huangzhen Wang Yiwen Zhang Shou-Ching Tang 3, 4 Jichang 5 Ning Du Chongwen Xu Chenguang 6 Sida Qin Jia Dapeng Yunfeng Xiaojun Li Jiansheng Jun Dong 7 8 Shaohua 9 Zhen Tao 10 Fei 11 Jie Zhou 12 13 Hong Ren Department of Thoracic Surgery and Oncology, the First Affiliated Hospital Xi’an Jiaotong University, Xi’an, Shaanxi Province, 710061, China 2 Obstetrics Gynecology, Second Wenzhou Medical Wenzhou, Zhejiang 325027, 3 Breast Cancer...
During 18–22 July 2021, an extreme precipitation event occurred in Henan, China, with maximum daily reached 657 mm, broking their historical records and resulting severe disaster. This heavy rainstorm the background of two typhoon (In-fa Cempaka) activities, but resent studies have only considered effects individual typhoons, ignoring combined effects. The Dynamic Recycling Model Weather Research Forecasting were applied to investigate contributions typhoons on water vapor transportation....
Abstract Radiotherapy is essential for treating unresectable or metastatic breast cancer, but radiotherapy‐induced tumor cell death generates small extracellular vesicles (sEVs) that promote regrowth and metastasis following treatment. Here cationic nanosheets with a high sEVs‐binding capacity suppress sEVs‐induced radiotherapy developed. Molybdenum disulfide (MoS 2 ) monolayers are prepared by using lithium ions as intercalation agents, functionalized polyamidoamine (PAMAM) dendrimers. The...
Abstract Purpose Behavioral symptoms, including depression, anxiety, and cognitive impairment, are common clinical symptoms of patients with glioma. However, the mechanisms underlying behavioral glioma remain unclear. In this study, we explore correlation between markers systemic inflammation preoperational in patients. Patients Methods ( n = 71) who had recently undertaken imaging (i.e., CT, MRI) for suspected a face‐to‐face interview, completed self‐report scales, provided blood samples....
The thermal and humidity environments of buildings under the influence Heating, Ventilation Air Conditioning (HVAC) systems constitute a mature topic in field architecture, but there are few studies on traditional rural natural wind conditions. In this paper, one-seal residential building Kunming, Yunnan Province, was adopted as research object. By arranging monitoring instruments, we collected environment data three weather conditions: cloudy, sunny rainy days. results showed that climate...
Importance Peceleganan spray is a novel topical antimicrobial agent targeted for the treatment of skin wound infections. However, its efficacy and safety remain unclear. Objective To assess peceleganan Design, Setting, Participants This multicenter, open-label, phase 3 randomized clinical trial recruited followed up 570 adult patients diagnosed with secondary open infections from 37 hospitals in China August 23, 2021, to July 16, 2022. Interventions Patients were 2 groups 2:1 allocation. One...