A5050854769- Wound Healing and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Burn Injury Management and Outcomes
- Cancer-related molecular mechanisms research
- S100 Proteins and Annexins
- Immune Response and Inflammation
- Mesenchymal stem cell research
- Silk-based biomaterials and applications
- Peroxisome Proliferator-Activated Receptors
- Bone fractures and treatments
- Antimicrobial Peptides and Activities
- Pressure Ulcer Prevention and Management
- NF-κB Signaling Pathways
- Diabetic Foot Ulcer Assessment and Management
- RNA Interference and Gene Delivery
- Autophagy in Disease and Therapy
- Orthopedic Surgery and Rehabilitation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Thermal Regulation in Medicine
- Antimicrobial agents and applications
- Nonmelanoma Skin Cancer Studies
- Cleft Lip and Palate Research
- Lymphatic System and Diseases
- Thermoregulation and physiological responses
- Metabolomics and Mass Spectrometry Studies
Xiangya Hospital Central South University
2015-2024
Central South University
2015-2024
Abstract Our previous study demonstrated that angiogenesis increased during the recovery of heat-denatured endothelial cells. However, mechanism is still unclear. This aimed to investigate relation autophagy and A rat deep partial-thickness burn model human umbilical vein cells (HUVECs) (52 °C for 35 s) were used. Autophagy significantly in dermis HUVECs a time-dependent manner after heat denaturation 2–5 days. Rapamycin-mediated enhanced pro-angiogenic effect, evidenced by proliferation...
Denatured dermis is a part of the in deep burn wound and has ability to restore normal morphology function. In our previous study, we revealed that miR‐29a downregulation denatured may help healing later phase, further enhance type I collagen synthesis. LIN28A, highly‐conserved RNA binding protein expressed during embryogenesis, plays roles development, pluripotency, metabolism, as well tissue repair adults. present investigated functional LIN28A human skin fibroblasts (HSFs) extracellular...
Preservation of denatured dermis exerts promotive functions in wound healing and improves the appearance function skin. Angiogenesis is crucial for during burn injury. However, potential molecular mechanism angiogenesis recovery after injury remains to be elucidated. Herein, RNA chromatin immunoprecipitation (ChIP) sequencing analysis revealed upregulation long intergenic non-coding 00174 (linc00174) post-burn tissues. linc00174 overexpression promoted angiogenic activities human umbilical...
Decreased Th1/Th2 ratio is one of the major characteristics immunosuppression in sepsis. Both membrane adhesive protein Annexin-A1 (ANXA1) and transcription factor GATA-3 have been reported to play important roles T cell differentiation. However, relationship between ANXA1 shift unknown. Our study investigated interaction effects influence differentiation CD4 + cells. We found that were coexpressed on Th0/Th1/Th2 cytoplasm nuclear. Overexpressed significantly increased expression IFN γ...
Objective: To assess the safety and efficacy of antimicrobial peptide PL-5 (Peceleganan) spray in treatment wound infections. Background: Antimicrobial is a novel topical agent. Methods: We conducted multicenter, open-label, randomized, controlled phase IIb clinical trial to evaluate spray, as compared with silver sulfadiazine, patients skin The primary outcome was rate on first day after ending (D8). secondary fifth posttreatment (D5), bacteria clearance rate, overall at mentioned 2 time...
Abstract Background Slow lymphangiogenesis is one crucial reason for the impaired wound healing process in diabetes. Accumulative evidence showed that long noncoding RNA–antisense RNA INK4 locus (ANRIL) could influence lymphangiogenesis. Besides, miR‐181a has been reported to regulate Prox1 essential However, relationship between ANRIL and as well definitive function of not clear. Methods The diabetic mouse model was set up assess rate vivo. Quantitative real‐time polymerase chain reaction...
Our previous study has suggested that downregulated microRNA (miR)-29a in denatured dermis might be involved burn wound healing. However, the exact role of miR-29a healing injury still remains unclear. Here, we found expression was notably upregulated tissues and skin fibroblast cells after thermal injury, thereafter gradually compared with control group. By contrast, collagen, type I, alpha 2 (COL1A2) vascular endothelial growth factor (VEGF-A) were first reduced subsequently injury. We...
Importance Peceleganan spray is a novel topical antimicrobial agent targeted for the treatment of skin wound infections. However, its efficacy and safety remain unclear. Objective To assess peceleganan Design, Setting, Participants This multicenter, open-label, phase 3 randomized clinical trial recruited followed up 570 adult patients diagnosed with secondary open infections from 37 hospitals in China August 23, 2021, to July 16, 2022. Interventions Patients were 2 groups 2:1 allocation. One...
Background Skin grafting with the preservation of denatured dermis is a novel strategy for treatment burn-injured skin. Denatured has ability to restore morphology and function normal skin, but underlying molecular mechanism elusive. MicroRNAs (miRNA) are small noncoding RNAs regulate physiology as well disease development. In this study, we assessed potential role miRNA-23b (miR-23b) in regulation cell proliferation migration heat-denatured fibroblasts identified mechanism. Methods The...
N6-methyladenosine (m6A) modulates RNA metabolism and functions in cell differentiation, tissue development, immune response. After acute burns, skin wounds are highly susceptible to infection poor healing. However, our understanding of the effect burn injuries on m6A methylation their potential mechanism is still limited. Human m6A-mRNA&lncRNA Epitranscriptomic microarray was used obtain comprehensive mRNA lncRNA transcriptome profiling gene expression patterns after human tissue....
Denatured dermis, a part of dermis in burned skin, has the ability to restore its normal morphology and functions after their surrounding microenvironment is improved. However, cellular molecular mechanisms by which denatured could improve wound healing are still unclear. This study aimed investigate role nucleolin during recovery heat-denatured human dermal fibroblasts. Nucleolin mRNA protein expression were significantly increased time-dependently fibroblasts (52 °C, 30 seconds)....
Abstract Our previous study confirmed the critical role of miR‐125b and vascular endothelial growth factor (VEGF) in burn wound repair., The present was aimed to identify long noncoding RNAs (lncRNAs) related function VEGF repair underlying mechanism. First, we found that lncRNA PDK1‐AS VEGFA expression significantly increased heat‐denatured dermal tissue samples human microvascular cells (HDMECs) umbilical vein (HUVECs) after thermal injury. knockdown inhibited cell viability, cumulative...
To analyze the etiology and clinical characteristics of Marjolin's ulcer, to explore its prevention treatment.Medical records 187 patients with ulcers admitted Department Burns Reconstructive Surgery Xiangya Hospital Central South University from January 1998 May 2015 were retrospectively analyzed, including gender, age onset initial injury or primary disease, length latency, lengths pre- post-ulceration periods, lesion site, type, area, local scar tension, histopathological degree carcinoma...
ABSTRACT Epidermal growth factor (EGF) plays an important role in epithelial cell proliferation and apoptosis. Our recent studies found that EGF‐attenuated tumor necrosis factor‐α induced HaCaT keratinocyte apoptosis, this effect was accompanied by up‐regulation of the expression peroxisome proliferator‐activated receptor β (PPARβ). However, little is known about whether PPARβ functionally involved inhibition apoptosis EGF. Here, we showed EGF up‐regulated DNA‐binding transcriptional...
Background: To reveal the alterations of tRNA-derived small RNA (tsRNA) expression profiles induced by hyperbaric oxygen (HBO) treatment in diabetic foot ulcers (DFUs) and investigate new therapeutic targets. Materials & methods: tsRNA sequencing was employed normal skin tissue, DFUs, after HBO groups. A quantitative real-time PCR used to validate results their targets levels. Bioinformatics analysis performed functions DFUs. Results: total 22 tsRNAs were differentially expressed three Three...